4NKG
 
 | | Crystal structure of SspH1 LRR domain in complex PKN1 HR1b domain | | 分子名称: | E3 ubiquitin-protein ligase sspH1, HEXANE-1,6-DIOL, Serine/threonine-protein kinase N1 | | 著者 | Keszei, A.F.A, Xiaojing, T, Mccormick, C, Zeqiraj, E, Rohde, J.R, Tyers, M, Sicheri, F. | | 登録日 | 2013-11-12 | | 公開日 | 2013-12-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase.
Mol.Cell.Biol., 34, 2014
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4MDK
 | | Cdc34-ubiquitin-CC0651 complex | | 分子名称: | 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, Ubiquitin, Ubiquitin-conjugating enzyme E2 R1 | | 著者 | Ceccarelli, D.F, Orlicky, S, Tyers, M, Sicheri, F. | | 登録日 | 2013-08-22 | | 公開日 | 2013-12-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6095 Å) | | 主引用文献 | E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin.
Nat.Chem.Biol., 10, 2014
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4NKH
 | | Crystal structure of SspH1 LRR domain | | 分子名称: | E3 ubiquitin-protein ligase sspH1 | | 著者 | Keszei, A.F.A, Xiaojing, T, Mccormick, C, Zeqiraj, E, Rohde, J.R, Tyers, M, Sicheri, F. | | 登録日 | 2013-11-12 | | 公開日 | 2013-12-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase.
Mol.Cell.Biol., 34, 2014
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4O1O
 | | Crystal Structure of RNase L in complex with 2-5A | | 分子名称: | Ribonuclease L, [[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-3-hydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate | | 著者 | Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2013-12-16 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.27 Å) | | 主引用文献 | Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
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4O1P
 | | Crystal Structure of RNase L in complex with 2-5A and AMP-PNP | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribonuclease L, ... | | 著者 | Huang, H, Zeqiraj, E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2013-12-16 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity.
Mol.Cell, 53, 2014
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7KJU
 | | Cgi121-tRNA complex | | 分子名称: | MAGNESIUM ION, RNA (75-MER) | | 著者 | Ceccarelli, D.F, Beenstock, J, Wan, L.C.K, Sicheri, F. | | 登録日 | 2020-10-26 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.102 Å) | | 主引用文献 | A substrate binding model for the KEOPS tRNA modifying complex.
Nat Commun, 11, 2020
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4PL4
 | | Crystal structure of murine IRE1 in complex with OICR464 inhibitor | | 分子名称: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 2-methoxy-6-methyl-4-(4-methyl-3,4-dihydro-2H-1,4-benzoxazin-7-yl)phenol, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | | 登録日 | 2014-05-16 | | 公開日 | 2014-09-03 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nat Commun, 5, 2014
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7LUO
 | | N-terminus of Skp2 bound to Cyclin A | | 分子名称: | S-phase kinase-associated protein 2,Cyclin-A2, Skp2 Motif 1 uncharacterized fragment 1, Skp2 Motif 1 uncharacterized fragment 2 | | 著者 | Kelso, S, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2021-02-22 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.17 Å) | | 主引用文献 | Bipartite binding of the N terminus of Skp2 to cyclin A.
Structure, 29, 2021
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2KIS
 | | Solution structure of CA150 FF1 domain and FF1-FF2 interdomain linker | | 分子名称: | Transcription elongation regulator 1 | | 著者 | Murphy, J.M, Hansen, D, Wiesner, S, Muhandiram, D, Borg, M, Smith, M.J, Sicheri, F, Kay, L.E, Forman-Kay, J.D, Pawson, T. | | 登録日 | 2009-05-08 | | 公開日 | 2009-09-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural studies of FF domains of the transcription factor CA150 provide insights into the organization of FF domain tandem arrays.
J.Mol.Biol., 393, 2009
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4PL5
 | | Crystal structure of murine IRE1 in complex with OICR573 inhibitor | | 分子名称: | 2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59,62,65,68,71,74,77,80-HEPTACOSAOXADOOCTACONTAN-82-OL, 3-methoxy-5-methyl-4'-(morpholin-4-yl)biphenyl-4-ol, ADENOSINE-5'-DIPHOSPHATE, ... | | 著者 | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | | 登録日 | 2014-05-16 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nat Commun, 5, 2014
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4QLB
 | | Structural Basis for the Recruitment of Glycogen Synthase by Glycogenin | | 分子名称: | GLYCEROL, Probable glycogen [starch] synthase, Protein GYG-1, ... | | 著者 | Zeqiraj, E, Judd, A, Sicheri, F. | | 登録日 | 2014-06-11 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for the recruitment of glycogen synthase by glycogenin.
Proc.Natl.Acad.Sci.USA, 111, 2014
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2HJN
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4PDS
 | | Crystal structure of Rad53 kinase domain and SCD2 in complex with AMPPNP | | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase RAD53 | | 著者 | Ho, C.S, Wybenga-Groot, L.E, Ceccarelli, D.F, Sicheri, F. | | 登録日 | 2014-04-21 | | 公開日 | 2014-05-28 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis of Rad53 kinase activation by dimerization and activation segment exchange.
Cell Signal., 26, 2014
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7LUL
 | | Structure of the MM2 Erbin PDZ variant in complex with a high-affinity peptide | | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Singer, A.U, Teyra, J, McLaughlin, M, Ernst, A, Sicheri, F, Sidhu, S.S. | | 登録日 | 2021-02-22 | | 公開日 | 2021-07-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Comprehensive Assessment of the Relationship Between Site -2 Specificity and Helix alpha 2 in the Erbin PDZ Domain.
J.Mol.Biol., 433, 2021
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4PL3
 | | Crystal structure of murine IRE1 in complex with MKC9989 inhibitor | | 分子名称: | 7-hydroxy-6-methoxy-3-[2-(2-methoxyethoxy)ethyl]-4,8-dimethyl-2H-chromen-2-one, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | 著者 | Sanches, M, Duffy, N, Talukdar, M, Thevakumaran, N, Chiovitti, D, Al-awar, R, Patterson, J.B, Sicheri, F. | | 登録日 | 2014-05-16 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors.
Nat Commun, 5, 2014
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7KJT
 | | KEOPS tRNA modifying sub-complex of archaeal Cgi121 and tRNA | | 分子名称: | RNA (70-MER), Regulatory protein Cgi121 | | 著者 | Ceccarelli, D.F, Beenstock, J, Mao, D.Y.L, Sicheri, F. | | 登録日 | 2020-10-26 | | 公開日 | 2020-12-02 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | | 主引用文献 | A substrate binding model for the KEOPS tRNA modifying complex.
Nat Commun, 11, 2020
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7M3Q
 | | Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV) | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, ... | | 著者 | Chowdhury, A, Singer, A.U, Ogunjimi, A.A, Teyra, J, Zhang, W, Sicheri, F, Sidhu, S.S. | | 登録日 | 2021-03-18 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
To be published
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4PDP
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2K8Y
 | | Solution NMR Structure of Cgi121 from Methanococcus jannaschii. Northeast Structural Genomics Consortium Target MJ0187 | | 分子名称: | Uncharacterized protein MJ0187 | | 著者 | Rumpel, S, Fares, C, Neculai, D, Arrowsmith, C, Montelione, G.T, Sicheri, F, Northeast Structural Genomics Consortium (NESG) | | 登録日 | 2008-09-25 | | 公開日 | 2008-11-04 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine.
Mol.Cell, 32, 2008
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2JQZ
 | | Solution Structure of the C2 domain of human Smurf2 | | 分子名称: | E3 ubiquitin-protein ligase SMURF2 | | 著者 | Wiesner, S, Ogunjimi, A.A, Wang, H, Rotin, D, Sicheri, F, Wrana, J.L, Forman-Kay, J.D. | | 登録日 | 2007-06-15 | | 公開日 | 2007-09-11 | | 最終更新日 | 2024-05-08 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Autoinhibition of the HECT-Type Ubiquitin Ligase Smurf2 through Its C2 Domain
Cell(Cambridge,Mass.), 130, 2007
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2F8K
 | | Sequence specific recognition of RNA hairpins by the SAM domain of Vts1 | | 分子名称: | 5'-R(*UP*AP*AP*UP*CP*UP*UP*UP*GP*AP*CP*AP*GP*AP*UP*U)-3', Protein VTS1 | | 著者 | Aviv, T, Lin, Z, Ben-Ari, G, Smibert, C.A, Sicheri, F. | | 登録日 | 2005-12-02 | | 公開日 | 2006-01-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Sequence-specific recognition of RNA hairpins by the SAM domain of Vts1p.
Nat.Struct.Mol.Biol., 13, 2006
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2HEN
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2HEL
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3RZ3
 | | Human Cdc34 E2 in complex with CC0651 inhibitor | | 分子名称: | 4,5-dideoxy-5-(3',5'-dichlorobiphenyl-4-yl)-4-[(methoxyacetyl)amino]-L-arabinonic acid, Ubiquitin-conjugating enzyme E2 R1 | | 著者 | Ceccarelli, D.F, Webb, D.R, Sicheri, F. | | 登録日 | 2011-05-11 | | 公開日 | 2011-07-06 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | An allosteric inhibitor of the human cdc34 ubiquitin conjugating enzyme
Cell(Cambridge,Mass.), 145, 2011
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8TTQ
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