4QC0
 
 | | Crystal structure of human TLR8 in complex with XG-1-236 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl-2H-pyrazolo[3,4-c]quinolin-4-amine, Toll-like receptor 8, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2014-05-09 | | 公開日 | 2014-10-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014
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4R09
 | | Crystal structure of human TLR8 in complex with ORN06S | | 分子名称: | 1-[(2R,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-sulfidotetrahydrofuro[3,4-d][1,3,2]dioxaphosphol-4-yl]pyrimidine-2,4(1H,3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2014-07-30 | | 公開日 | 2015-01-14 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Toll-like receptor 8 senses degradation products of single-stranded RNA.
Nat.Struct.Mol.Biol., 22, 2015
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4QBZ
 | | Crystal structure of human TLR8 in complex with DS-802 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butyl[1,3]oxazolo[4,5-c]quinolin-4-amine, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2014-05-09 | | 公開日 | 2014-10-22 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Determinants of Activity at Human Toll-like Receptors 7 and 8: Quantitative Structure-Activity Relationship (QSAR) of Diverse Heterocyclic Scaffolds
J.Med.Chem., 57, 2014
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5GMG
 | | Crystal structure of monkey TLR7 in complex with loxoribine and polyU | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]-7-prop-2-enyl-1~{H}-purine-6,8-dione, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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5GMH
 | | Crystal structure of monkey TLR7 in complex with R848 | | 分子名称: | 1-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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4ZLC
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4ZLD
 | | Crystal structure of human Roquin-2 ROQ domain in complex with Roquin CDE RNA | | 分子名称: | GLYCEROL, RNA (5'-R(*UP*AP*AP*CP*UP*UP*CP*UP*GP*UP*GP*AP*AP*GP*UP*UP*G)-3'), Roquin-2 | | 著者 | Sakurai, S, Ohto, U, Shimizu, T. | | 登録日 | 2015-05-01 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structure of human Roquin-2 and its complex with constitutive-decay element RNA
Acta Crystallogr.,Sect.F, 71, 2015
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5AWB
 | | Crystal structure of human TLR8 in complex with N1-3-aminomethylbenzyl (meta-amine) | | 分子名称: | 1-[[3-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2015-07-03 | | 公開日 | 2015-09-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.
J.Med.Chem., 58, 2015
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5AWC
 | | Crystal structure of human TLR8 in complex with MB-564 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(4-azanylbutyl)-3-pentyl-quinolin-2-amine, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2015-07-03 | | 公開日 | 2016-07-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity
To Be Published
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5IRM
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5HDH
 | | Crystal structure of human TLR8 with an uncleaved Z-loop | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2016-01-05 | | 公開日 | 2016-03-09 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8
Proc.Natl.Acad.Sci.USA, 113, 2016
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5GMF
 | | Crystal structure of monkey TLR7 in complex with guanosine and polyU | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2016-07-14 | | 公開日 | 2016-11-02 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA
Immunity, 45, 2016
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5IRN
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5IRL
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5AWA
 | | Crystal structure of human TLR8 in complex with MB-568 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-[[3-(aminomethyl)phenyl]methyl]-3-pentyl-quinolin-2-amine, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2015-07-03 | | 公開日 | 2016-07-20 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure-based Design of Human TLR8-specific Agonists with Augmented Potency and Adjuvanticity
To Be Published
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5AZ5
 | | Crystal structure of human TLR8 in complex with MB-343 | | 分子名称: | 1-pentyl-4-phenyl-imidazol-2-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2015-09-27 | | 公開日 | 2016-10-05 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of human TLR8 in complex with MB-343
To Be Published
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5AWD
 | | Crystal structure of human TLR8 in complex with N1-4-aminomethylbenzyl (IMDQ) | | 分子名称: | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2015-07-03 | | 公開日 | 2015-09-23 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.
J.Med.Chem., 58, 2015
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5XDR
 | | Crystal structure of human DEAH-box RNA helicase DHX15 in complex with ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15, ... | | 著者 | Murakami, K, Nakano, K, Shimizu, T, Ohto, U. | | 登録日 | 2017-03-29 | | 公開日 | 2017-06-21 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family
Acta Crystallogr F Struct Biol Commun, 73, 2017
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5Y7Y
 | | Crystal structure of AhRR/ARNT complex | | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Aryl hydrocarbon receptor repressor, GLYCEROL | | 著者 | Sakurai, S, Shimizu, T, Ohto, U. | | 登録日 | 2017-08-18 | | 公開日 | 2017-09-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The crystal structure of the AhRR-ARNT heterodimer reveals the structural basis of the repression of AhR-mediated transcription.
J. Biol. Chem., 292, 2017
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5Z15
 | | Crystal structure of human TLR8 in complex with CU-CPT9c | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(7-chloranylquinolin-4-yl)-2-methyl-phenol, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2017-12-25 | | 公開日 | 2018-07-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State
To Be Published
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5Z14
 | | Crystal structure of human TLR8 in complex with CU-CPT9a | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(7-methoxyquinolin-4-yl)-2-methyl-phenol, ... | | 著者 | Tanji, H, Ohto, U, Shimizu, T. | | 登録日 | 2017-12-25 | | 公開日 | 2018-07-04 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State
To Be Published
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5ZLN
 | | Crystal structure of mouse TLR9 in complex with two DNAs (CpG DNA and TCGCCA DNA) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DNA (5'-D(*AP*GP*GP*CP*GP*TP*TP*TP*TP*T)-3'), ... | | 著者 | Ishida, H, Ohto, U, Shimizu, T. | | 登録日 | 2018-03-28 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for species-specific activation of mouse Toll-like receptor 9
FEBS Lett., 592, 2018
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5ZSH
 | | Crystal structure of monkey TLR7 in complex with CL075 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-propyl[1,3]thiazolo[4,5-c]quinolin-4-amine, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2018-04-28 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
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5ZSL
 | | Crystal structure of monkey TLR7 in complex with GGUUGG | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-9-[(2S,3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxotetrahydro-2H-2lambda~5~-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-3,9-dihydro-6H-purin-6-one, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2018-04-28 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
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5ZSE
 | | Crystal structure of monkey TLR7 in complex with IMDQ and GGUCCC | | 分子名称: | 1-[[4-(aminomethyl)phenyl]methyl]-2-butyl-imidazo[4,5-c]quinolin-4-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Zhang, Z, Ohto, U, Shimizu, T. | | 登録日 | 2018-04-28 | | 公開日 | 2019-01-30 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.201 Å) | | 主引用文献 | Structural Analyses of Toll-like Receptor 7 Reveal Detailed RNA Sequence Specificity and Recognition Mechanism of Agonistic Ligands.
Cell Rep, 25, 2018
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