8EXS
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![BU of 8exs by Molmil](/molmil-images/mine/8exs) | Cryo-EM structure of S. aureus BlaR1 F284A mutant | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | 著者 | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2022-10-25 | 公開日 | 2023-01-11 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus. Nature, 613, 2023
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8EXT
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![BU of 8ext by Molmil](/molmil-images/mine/8ext) | Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | 著者 | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | 登録日 | 2022-10-25 | 公開日 | 2023-01-11 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus. Nature, 613, 2023
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5GNS
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![BU of 5gns by Molmil](/molmil-images/mine/5gns) | Structures of human Mitofusin 1 provide insight into mitochondrial tethering | 分子名称: | GUANOSINE-5'-TRIPHOSPHATE, Mitofusin-1 | 著者 | Qi, Y, Yan, L, Yu, C, Guo, X, Zhou, X, Hu, X, Huang, X, Rao, Z, Lou, Z, Hu, J. | 登録日 | 2016-07-24 | 公開日 | 2016-12-07 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | 主引用文献 | Structures of human Mitofusin 1 provide insight into mitochondrial tethering To Be Published
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6OC5
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![BU of 6oc5 by Molmil](/molmil-images/mine/6oc5) | Lanthanide-dependent methanol dehydrogenase XoxF from Methylobacterium extorquens, in complex with Lanthanum | 分子名称: | LANTHANUM (III) ION, Lanthanide-dependent methanol dehydrogenase XoxF | 著者 | Fellner, M, Good, N.M, Martinez-Gomez, N.C, Hausinger, R.P, Hu, J. | 登録日 | 2019-03-21 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function. J.Biol.Chem., 295, 2020
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6OC6
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![BU of 6oc6 by Molmil](/molmil-images/mine/6oc6) | Lanthanide-dependent methanol dehydrogenase XoxF from Methylobacterium extorquens, in complex with Lanthanum and Pyrroloquinoline quinone | 分子名称: | LANTHANUM (III) ION, Lanthanide-dependent methanol dehydrogenase XoxF, PYRROLOQUINOLINE QUINONE | 著者 | Fellner, M, Good, N.M, Martinez-Gomez, N.C, Hausinger, R.P, Hu, J. | 登録日 | 2019-03-21 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | 主引用文献 | Lanthanide-dependent alcohol dehydrogenases require an essential aspartate residue for metal coordination and enzymatic function. J.Biol.Chem., 295, 2020
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3FP2
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![BU of 3fp2 by Molmil](/molmil-images/mine/3fp2) | Crystal structure of Tom71 complexed with Hsp82 C-terminal fragment | 分子名称: | ATP-dependent molecular chaperone HSP82, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Li, J, Qian, X, Hu, J, Sha, B. | 登録日 | 2009-01-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading. J.Biol.Chem., 284, 2009
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3FP3
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![BU of 3fp3 by Molmil](/molmil-images/mine/3fp3) | Crystal structure of Tom71 | 分子名称: | CHLORIDE ION, SULFATE ION, TPR repeat-containing protein YHR117W | 著者 | Li, J, Qian, X, Hu, J, Sha, B. | 登録日 | 2009-01-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading. J.Biol.Chem., 284, 2009
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4DAJ
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![BU of 4daj by Molmil](/molmil-images/mine/4daj) | Structure of the M3 Muscarinic Acetylcholine Receptor | 分子名称: | (1R,2R,4S,5S,7S)-7-{[hydroxy(dithiophen-2-yl)acetyl]oxy}-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.0~2,4~]nonane, Muscarinic acetylcholine receptor M3, Lysozyme, ... | 著者 | Kruse, A.C, Hu, J, Pan, A.C, Arlow, D.H, Rosenbaum, D.M, Rosemond, E, Green, H.F, Liu, T, Chae, P.S, Dror, R.O, Shaw, D.E, Weis, W.I, Wess, J, Kobilka, B. | 登録日 | 2012-01-12 | 公開日 | 2012-02-22 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature, 482, 2012
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8UC2
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![BU of 8uc2 by Molmil](/molmil-images/mine/8uc2) | Ethylene forming enzyme (EFE) R171A variant in complex with nickel and Benzoic acid | 分子名称: | 1,2-ETHANEDIOL, 2-oxoglutarate-dependent ethylene/succinate-forming enzyme, BENZOIC ACID, ... | 著者 | Chatterjee, S, Rankin, J.A, Hu, J, Hausinger, R. | 登録日 | 2023-09-25 | 公開日 | 2023-10-04 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural, Spectroscopic, and Computational Insights from Canavanine-Bound and Two Catalytically Compromised Variants of the Ethylene-Forming Enzyme. Biochemistry, 63, 2024
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3FP4
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![BU of 3fp4 by Molmil](/molmil-images/mine/3fp4) | Crystal structure of Tom71 complexed with Ssa1 C-terminal fragment | 分子名称: | CHLORIDE ION, SODIUM ION, SULFATE ION, ... | 著者 | Li, J, Qian, X, Hu, J, Sha, B. | 登録日 | 2009-01-03 | 公開日 | 2009-07-28 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | 主引用文献 | Molecular chaperone Hsp70/Hsp90 prepares the mitochondrial outer membrane translocon receptor Tom71 for preprotein loading. J.Biol.Chem., 284, 2009
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8EZF
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![BU of 8ezf by Molmil](/molmil-images/mine/8ezf) | A tethered niacin-derived pincer complex with a nickel-carbon or sulfite-carbon bond in lactate racemase R98A/R100A variant | 分子名称: | (4S)-5-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-4-sulfo-1,4-dihydropyridine-3-carbothioic S-acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | 著者 | Gatreddi, S, Hausinger, R.P, Hu, J. | 登録日 | 2022-10-31 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Irreversible inactivation of lactate racemase by sodium borohydride reveals reactivity of the nickel-pincer nucleotide cofactor. Acs Catalysis, 13, 2023
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8EZI
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![BU of 8ezi by Molmil](/molmil-images/mine/8ezi) | A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase R98A/R100A variant modeled with separated sulfite and NPN | 分子名称: | 1,2-ETHANEDIOL, 3-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium, CALCIUM ION, ... | 著者 | Gatreddi, S, Hausinger, R.P, Hu, J. | 登録日 | 2022-10-31 | 公開日 | 2023-01-25 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Irreversible inactivation of lactate racemase by sodium borohydride reveals reactivity of the nickel-pincer nucleotide cofactor. Acs Catalysis, 13, 2023
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8EZH
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![BU of 8ezh by Molmil](/molmil-images/mine/8ezh) | A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase R98A/R100A variant modeled with sulfite-NPN adduct | 分子名称: | (4S)-5-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-4-sulfo-1,4-dihydropyridine-3-carbothioic S-acid, 1,2-ETHANEDIOL, CALCIUM ION, ... | 著者 | Gatreddi, S, Hausinger, R.P, Hu, J. | 登録日 | 2022-10-31 | 公開日 | 2023-01-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Irreversible inactivation of lactate racemase by sodium borohydride reveals reactivity of the nickel-pincer nucleotide cofactor. Acs Catalysis, 13, 2023
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5FBH
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![BU of 5fbh by Molmil](/molmil-images/mine/5fbh) | Crystal structure of the extracellular domain of human calcium sensing receptor with bound Gd3+ | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ... | 著者 | Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J. | 登録日 | 2015-12-14 | 公開日 | 2016-06-22 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist. Sci Adv, 2, 2016
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5FBK
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![BU of 5fbk by Molmil](/molmil-images/mine/5fbk) | Crystal structure of the extracellular domain of human calcium sensing receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BICARBONATE ION, CHLORIDE ION, ... | 著者 | Zhang, T, Zhang, C, Miller, C.L, Zou, J, Moremen, K.W, Brown, E.M, Yang, J.J, Hu, J. | 登録日 | 2015-12-14 | 公開日 | 2016-06-22 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis for regulation of human calcium-sensing receptor by magnesium ions and an unexpected tryptophan derivative co-agonist. Sci Adv, 2, 2016
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2AUH
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![BU of 2auh by Molmil](/molmil-images/mine/2auh) | Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase | 分子名称: | CALCIUM ION, Growth factor receptor-bound protein 14, Insulin receptor | 著者 | Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R. | 登録日 | 2005-08-27 | 公開日 | 2005-11-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20, 2005
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2AUG
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![BU of 2aug by Molmil](/molmil-images/mine/2aug) | Crystal structure of the Grb14 SH2 domain | 分子名称: | Growth factor receptor-bound protein 14 | 著者 | Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R. | 登録日 | 2005-08-27 | 公開日 | 2005-11-01 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20, 2005
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5HUQ
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![BU of 5huq by Molmil](/molmil-images/mine/5huq) | A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase | 分子名称: | 3-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-5-(sulfanylcarbonyl)pyridin-1-ium, Lactate racemization operon protein LarA, NICKEL (II) ION, ... | 著者 | Desguin, B, Zhang, T, Soumillion, P, Hols, P, Hu, J, Hausinger, R.P. | 登録日 | 2016-01-27 | 公開日 | 2016-02-10 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | METALLOPROTEINS. A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase. Science, 349, 2015
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4X82
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![BU of 4x82 by Molmil](/molmil-images/mine/4x82) | |
6UTR
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![BU of 6utr by Molmil](/molmil-images/mine/6utr) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with copper | 分子名称: | ATP-dependent sacrificial sulfur transferase LarE, COPPER (II) ION, PHOSPHATE ION, ... | 著者 | Fellner, M, Huizenga, K, Hausinger, R.P, Hu, J. | 登録日 | 2019-10-29 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Sci Rep, 10, 2020
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6UTQ
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![BU of 6utq by Molmil](/molmil-images/mine/6utq) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with cadmium | 分子名称: | ATP-dependent sacrificial sulfur transferase LarE, CADMIUM ION, PHOSPHATE ION, ... | 著者 | Fellner, M, Huizenga, K, Hausinger, R.P, Hu, J. | 登録日 | 2019-10-29 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Sci Rep, 10, 2020
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6UTT
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![BU of 6utt by Molmil](/molmil-images/mine/6utt) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with calcium | 分子名称: | ATP-dependent sacrificial sulfur transferase LarE, CALCIUM ION, PHOSPHATE ION, ... | 著者 | Fellner, M, Huizenga, K, Hausinger, R.P, Hu, J. | 登録日 | 2019-10-29 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Sci Rep, 10, 2020
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6UTP
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![BU of 6utp by Molmil](/molmil-images/mine/6utp) | LarE, a sulfur transferase involved in synthesis of the cofactor for lactate racemase in complex with cobalt | 分子名称: | ATP-dependent sacrificial sulfur transferase LarE, COBALT (II) ION, PHOSPHATE ION, ... | 著者 | Fellner, M, Huizenga, K, Hausinger, R.P, Hu, J. | 登録日 | 2019-10-29 | 公開日 | 2019-11-06 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | 主引用文献 | Crystallographic characterization of a tri-Asp metal-binding site at the three-fold symmetry axis of LarE. Sci Rep, 10, 2020
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8STD
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![BU of 8std by Molmil](/molmil-images/mine/8std) | S127A variant of LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with authentic substrate NaAD and soaked with CS2 | 分子名称: | MAGNESIUM ION, NICOTINIC ACID ADENINE DINUCLEOTIDE, Pyridinium-3,5-biscarboxylic acid mononucleotide synthase | 著者 | Chatterjee, S, Rankin, J.A, Hu, J, Hausinger, R.P. | 登録日 | 2023-05-10 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structure of the LarB-Substrate Complex and Identification of a Reaction Intermediate during Nickel-Pincer Nucleotide Cofactor Biosynthesis. Biochemistry, 62, 2023
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8SOQ
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![BU of 8soq by Molmil](/molmil-images/mine/8soq) | S127A variant of LarB, a carboxylase/hydrolase involved in synthesis of the cofactor for lactate racemase, in complex with authentic substrate NaAD | 分子名称: | MAGNESIUM ION, NICOTINIC ACID ADENINE DINUCLEOTIDE, Pyridinium-3,5-biscarboxylic acid mononucleotide synthase | 著者 | Chatterjee, S, Rankin, J.A, Hu, J, Hausinger, R.P. | 登録日 | 2023-04-29 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structure of the LarB-Substrate Complex and Identification of a Reaction Intermediate during Nickel-Pincer Nucleotide Cofactor Biosynthesis. Biochemistry, 62, 2023
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