8EZH
A tethered niacin-derived pincer complex with a nickel-carbon bond in lactate racemase R98A/R100A variant modeled with sulfite-NPN adduct
Summary for 8EZH
| Entry DOI | 10.2210/pdb8ezh/pdb |
| Descriptor | Lactate racemase, 1,2-ETHANEDIOL, (4S)-5-methanethioyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-4-sulfo-1,4-dihydropyridine-3-carbothioic S-acid, ... (8 entities in total) |
| Functional Keywords | catalytic activity, isomerase activity, racemase and epimerase activity racemase acting on hydroxy acids and derivatives, isomerase, metal ion binding |
| Biological source | Lactiplantibacillus plantarum WCFS1 |
| Total number of polymer chains | 1 |
| Total formula weight | 48234.87 |
| Authors | Gatreddi, S.,Hausinger, R.P.,Hu, J. (deposition date: 2022-10-31, release date: 2023-01-25, Last modification date: 2023-11-08) |
| Primary citation | Gatreddi, S.,Sui, D.,Hausinger, R.P.,Hu, J. Irreversible inactivation of lactate racemase by sodium borohydride reveals reactivity of the nickel-pincer nucleotide cofactor. Acs Catalysis, 13:1441-1448, 2023 Cited by PubMed: 37886035DOI: 10.1021/acscatal.2c05461 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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