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5TE4
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BU of 5te4 by Molmil
Crystal Structure of Broadly Neutralizing VRC01-class Antibody N6 in Complex with HIV-1 Clade G Strain X2088 gp120 Core
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, (R,R)-2,3-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhou, T, Kwong, P.D.
登録日2016-09-20
公開日2016-11-23
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.
Immunity, 45, 2016
5V7J
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BU of 5v7j by Molmil
Crystal Structure at 3.7 A Resolution of Glycosylated HIV-1 Clade A BG505 SOSIP.664 Prefusion Env Trimer with Four Glycans (N197, N276, N362, and N462) removed in Complex with Neutralizing Antibodies 3H+109L and 35O22.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody 35O22 Fab heavy chain, ...
著者Stewart-Jones, G.B.E, Zhou, T, Kwong, P.D.
登録日2017-03-20
公開日2017-06-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.907 Å)
主引用文献Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.
Cell Rep, 19, 2017
5JOE
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BU of 5joe by Molmil
Crystal structure of I81 from titin
分子名称: 1,2-ETHANEDIOL, ISOPROPYL ALCOHOL, Titin
著者Fleming, J, Zhou, T, Bogomolovas, J, Labeit, S, Mayans, O.
登録日2016-05-02
公開日2016-08-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献CARP interacts with titin at a unique helical N2A sequence and at the domain Ig81 to form a structured complex.
Febs Lett., 590, 2016
5JXA
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BU of 5jxa by Molmil
Crystal structure of ligand-free VRC03 antigen-binding fragment.
分子名称: 1,2-ETHANEDIOL, COPPER (II) ION, PHOSPHATE ION, ...
著者Zhou, T, Moquin, S, Joyce, M.G, Mascola, J.R, Kwong, P.D.
登録日2016-05-12
公開日2016-07-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies.
Structure, 24, 2016
7TCQ
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BU of 7tcq by Molmil
Crystal structure of SARS-CoV-2 neutralizing antibody WS6 in complex with spike S2 peptide
分子名称: Anti-SARS-CoV-2 antibody WS6 Fab heavy chain, Anti-SARS-CoV-2 antibody WS6 Fab light chain, DI(HYDROXYETHYL)ETHER, ...
著者Zhou, T, Kwong, P.D.
登録日2021-12-28
公開日2022-08-03
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Vaccine-elicited murine antibody WS6 neutralizes diverse beta-coronaviruses by recognizing a helical stem supersite of vulnerability.
Structure, 30, 2022
3IK3
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BU of 3ik3 by Molmil
AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance
分子名称: 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Proto-oncogene tyrosine-protein kinase ABL1
著者Zhou, T.
登録日2009-08-05
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.
Cancer Cell, 16, 2009
8FBW
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BU of 8fbw by Molmil
Crystal structure of SIV-1 V2 antibody NCI05 in complex with a V2 peptide
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, DI(HYDROXYETHYL)ETHER, ...
著者Zhou, T, Kwong, P.D, Van Wazer, D.J.
登録日2022-11-30
公開日2023-01-18
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Effect of Passive Administration of Monoclonal Antibodies Recognizing Simian Immunodeficiency Virus (SIV) V2 in CH59-Like Coil/Helical or beta-Sheet Conformations on Time of SIV mac251 Acquisition.
J.Virol., 97, 2023
7MLZ
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BU of 7mlz by Molmil
Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain
分子名称: B1-182.1 Fab heavy chain, B1-182.1 Fab light chain, Spike protein S1, ...
著者Zhou, T, Tsybovsky, T, Kwong, P.D.
登録日2021-04-29
公開日2021-07-28
最終更新日2021-08-25
実験手法ELECTRON MICROSCOPY (3.71 Å)
主引用文献Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
Science, 373, 2021
7MM0
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BU of 7mm0 by Molmil
Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B1-182.1 Fab heavy chain, ...
著者Zhou, T, Tsybovsky, T, Kwong, P.D.
登録日2021-04-29
公開日2021-07-28
最終更新日2024-10-09
実験手法ELECTRON MICROSCOPY (3.15 Å)
主引用文献Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
Science, 373, 2021
7LRT
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BU of 7lrt by Molmil
Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody A23-58.1 that targets the receptor-binding domain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SARS-CoV-2 spike glycoprotein, ...
著者Zhou, T, Tsybovsky, T.
登録日2021-02-17
公開日2021-07-14
最終更新日2021-08-25
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
Science, 373, 2021
7LRS
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BU of 7lrs by Molmil
Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody A23-58.1 that targets the receptor-binding domain
分子名称: Spike glycoprotein, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, antibody A23-58.1 heavy chain, ...
著者Zhou, T, Tsybovsky, Y.
登録日2021-02-17
公開日2021-07-14
最終更新日2021-08-25
実験手法ELECTRON MICROSCOPY (3.89 Å)
主引用文献Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
Science, 373, 2021
6SZZ
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BU of 6szz by Molmil
Crystal structure of Cold Shock Protein B (CspB) containing the modified residue 4-F-Trp
分子名称: Cold shock protein CspD, GLYCEROL
著者Zhou, T, Mayans, O.
登録日2019-10-02
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献What does fluorine do to a protein? Thermodynamic, and highly-resolved structural insights into fluorine-labelled variants of the cold shock protein.
Sci Rep, 10, 2020
6T00
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BU of 6t00 by Molmil
Crystal structure of Cold Shock Protein B (CSP-B) containing 4-F-Phe modified residues
分子名称: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Cold shock protein CspD, GLYCEROL
著者Zhou, T, Mayans, O.
登録日2019-10-02
公開日2020-02-26
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献What does fluorine do to a protein? Thermodynamic, and highly-resolved structural insights into fluorine-labelled variants of the cold shock protein.
Sci Rep, 10, 2020
7MXD
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BU of 7mxd by Molmil
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC117 antibody heavy chain, ...
著者Zhou, T, Gao, F.
登録日2021-05-19
公開日2022-03-30
最終更新日2022-06-22
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.
Adv Sci, 9, 2022
7N28
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BU of 7n28 by Molmil
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC117 antibody heavy chain, ...
著者Zhou, T, Gao, F.
登録日2021-05-28
公開日2022-04-06
最終更新日2022-06-22
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.
Adv Sci, 9, 2022
6URM
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BU of 6urm by Molmil
Crystal structure of vaccine-elicited receptor-binding site targeting antibody LPAF-a.01 in complex with Hemagglutinin H1 A/California/04/2009
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
著者Zhou, T, Cheung, S.F, Kwong, P.D.
登録日2019-10-23
公開日2020-09-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation.
Cell Rep, 32, 2020
5F96
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BU of 5f96 by Molmil
Crystal structure of broadly neutralizing VH1-46 germline-derived CD4-binding site-directed antibody CH235.12 in complex with HIV-1 clade A/E 93TH057 gp120
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY CH235.12, ...
著者Zhou, T, Kwong, P.D.
登録日2015-12-09
公開日2016-03-09
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2407 Å)
主引用文献Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody.
Cell, 165, 2016
8TNH
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BU of 8tnh by Molmil
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site nanobody G36, ...
著者Zhou, T, Kwong, P.D, Xu, J.
登録日2023-08-01
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody G36 targeting the CD4-binding site
To Be Published
8TNI
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BU of 8tni by Molmil
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 BG505 DS-SOSIP gp120, ...
著者Zhou, T, Morano, N.C, Roark, R.S, Kwong, P.D, Xu, J.
登録日2023-08-01
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (3.61 Å)
主引用文献Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing bi-specific antibody CAP256L-R27 targeting the CD4-binding site and the V2-apex
To Be Published
8TNG
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BU of 8tng by Molmil
Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CD4-binding site targeting nanobody R27, ...
著者Zhou, T, Kwong, P.D, Xu, J.
登録日2023-08-01
公開日2024-05-08
実験手法ELECTRON MICROSCOPY (3.58 Å)
主引用文献Cryo-EM structure of HIV-1 Env BG505 DS-SOSIP in complex with broadly neutralizing llama nanobody R27 targeting the CD4-binding site
To Be Published
5EQE
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BU of 5eqe by Molmil
Crystal structure of choline kinase alpha-1 bound by [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine (compound 11)
分子名称: Choline kinase alpha, [4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]methanamine
著者Zhou, T, Zhu, X, Dalgarno, D.C.
登録日2015-11-12
公開日2016-01-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
J.Med.Chem., 59, 2016
5EQP
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BU of 5eqp by Molmil
Crystal structure of choline kinase alpha-1 bound by 6-[(4-methyl-1,4-diazepan-1-yl)methyl]quinoline (compound 37)
分子名称: 6-[(4-methyl-1,4-diazepan-1-yl)methyl]quinoline, Choline kinase alpha
著者Zhou, T, Zhu, X, Dalgarno, D.C.
登録日2015-11-13
公開日2016-01-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
J.Med.Chem., 59, 2016
5EQY
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BU of 5eqy by Molmil
Crystal structure of choline kinase alpha-1 bound by 5-[(4-methyl-1,4-diazepan-1-yl)methyl]-2-[4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]benzenecarbonitrile (compound 65)
分子名称: 5-[(4-methyl-1,4-diazepan-1-yl)methyl]-2-[4-[(4-methyl-1,4-diazepan-1-yl)methyl]phenyl]benzenecarbonitrile, Choline kinase alpha
著者Zhou, T, Zhu, X, Dalgarno, D.C.
登録日2015-11-13
公開日2016-01-06
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery.
J.Med.Chem., 59, 2016
4YFL
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BU of 4yfl by Molmil
Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120
分子名称: 1B2530 Light chain, 1B2530 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Acharya, P, Zhou, T, Moquin, S, Kwong, P.D.
登録日2015-02-25
公開日2015-06-03
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (3.387 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015
4YE4
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BU of 4ye4 by Molmil
Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, HT593.1 gp120, Heavy chain human antibody HJ16, ...
著者Kwong, P.D, Chen, L, Zhou, T.
登録日2015-02-23
公開日2015-07-22
最終更新日2022-03-30
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors.
Cell, 161, 2015

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