7EIL
 
 | | BRD4-BD1 in complex with LT-909-110 | | 分子名称: | Bromodomain-containing protein 4, N-[4-[4-ethanoyl-5-methyl-2-[6-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-pyrrol-3-yl]phenyl]ethanamide | | 著者 | Zheng, W, Kong, B, Tang, W, Zhu, J, Chen, Y. | | 登録日 | 2021-03-31 | | 公開日 | 2022-04-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Discovery of 1-(5-(1H-benzo[d]imidazole-2-yl)-2,4-dimethyl-1H-pyrrol-3-yl)ethan-1-one derivatives as novel and potent bromodomain and extra-terminal (BET) inhibitors with anticancer efficacy
Eur.J.Med.Chem., 227, 2022
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4WY4
 | | Crystal structure of autophagic SNARE complex | | 分子名称: | Synaptosomal-associated protein 29, Syntaxin-17, Vesicle-associated membrane protein 8 | | 著者 | Zhao, M, Brunger, A.T. | | 登録日 | 2014-11-15 | | 公開日 | 2015-02-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.
Nature, 520, 2015
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4YVU
 | | Crystal structure of CotA native enzyme in the acid condition, PH5.6 | | 分子名称: | 1,2-ETHANEDIOL, COPPER (II) ION, GLYCEROL, ... | | 著者 | Liu, Z.C, Xie, T, Wang, G.G. | | 登録日 | 2015-03-20 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of CotA laccase complexed with 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate) at a novel binding site
Acta Crystallogr.,Sect.F, 72, 2016
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7L5S
 | | Crystal Structure of Haemophilus influenzae MtsZ at pH 5.5 | | 分子名称: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, MOLYBDENUM ATOM, OXYGEN ATOM, ... | | 著者 | Struwe, M.A, Luo, Z, Kappler, U, Kobe, B. | | 登録日 | 2020-12-22 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.089 Å) | | 主引用文献 | Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes.
J.Biol.Chem., 296, 2021
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7L5I
 | | Crystal Structure of Haemophilus influenzae MtsZ at pH 7.0 | | 分子名称: | 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Struwe, M.A, Luo, Z, Kappler, U, Kobe, B. | | 登録日 | 2020-12-22 | | 公開日 | 2021-04-21 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.733 Å) | | 主引用文献 | Active site architecture reveals coordination sphere flexibility and specificity determinants in a group of closely related molybdoenzymes.
J.Biol.Chem., 296, 2021
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4YVN
 | | Crystal structure of CotA laccase complexed with ABTS at a novel binding site | | 分子名称: | 1,2-ETHANEDIOL, 3-ETHYL-2-[(2Z)-2-(3-ETHYL-6-SULFO-1,3-BENZOTHIAZOL-2(3H)-YLIDENE)HYDRAZINO]-6-SULFO-3H-1,3-BENZOTHIAZOL-1-IUM, COPPER (II) ION, ... | | 著者 | Liu, Z.C, Xie, T, Wang, G.G. | | 登録日 | 2015-03-20 | | 公開日 | 2016-03-30 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of CotA laccase complexed with 2,2-azinobis-(3-ethylbenzothiazoline-6-sulfonate) at a novel binding site
Acta Crystallogr.,Sect.F, 72, 2016
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8HAY
 | | d4-bound btDPP4 | | 分子名称: | (1~{R})-1-[[4-[5-[[(1~{R})-6,7-dimethoxy-2-methyl-3,4-dihydro-1~{H}-isoquinolin-1-yl]methyl]-2-methoxy-phenoxy]phenyl]methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1~{H}-isoquinoline, btDPP4 | | 著者 | Hang, J, Jiang, C, Wang, K, Zhang, Z, Guo, F, Liu, J, Wang, G, Lei, X, Gonzalez, F, Qiao, J. | | 登録日 | 2022-10-27 | | 公開日 | 2023-07-26 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | | 主引用文献 | Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.
Science, 381, 2023
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5CHL
 | | Structural basis of H2A.Z recognition by YL1 histone chaperone component of SRCAP/SWR1 chromatin remodeling complex | | 分子名称: | Histone H2A.Z, Vacuolar protein sorting-associated protein 72 homolog | | 著者 | Shan, S, Liang, X, Pan, L, Wu, C, Zhou, Z. | | 登録日 | 2015-07-10 | | 公開日 | 2016-03-09 | | 最終更新日 | 2017-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.892 Å) | | 主引用文献 | Structural basis of H2A.Z recognition by SRCAP chromatin-remodeling subunit YL1
Nat.Struct.Mol.Biol., 23, 2016
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6JYJ
 | | Crystal structure of FAM46B (TENT5B) | | 分子名称: | CITRATE ANION, Terminal nucleotidyltransferase 5B | | 著者 | Zhang, H, Hu, J.L, Gao, S. | | 登録日 | 2019-04-26 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.693199 Å) | | 主引用文献 | FAM46B is a prokaryotic-like cytoplasmic poly(A) polymerase essential in human embryonic stem cells.
Nucleic Acids Res., 48, 2020
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8KHR
 | | Cryo-EM structure of EBV gH/gL-gp42 in complex with fab 2C1 | | 分子名称: | 2C1 heavy chain, 2C1 light chain, Envelope glycoprotein H, ... | | 著者 | Fang, X.Y, Zhao, G.X, Zeng, M.S, Liu, Z. | | 登録日 | 2023-08-22 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | | 主引用文献 | Potent human monoclonal antibodies targeting Epstein-Barr virus gp42 reveal vulnerable sites for virus infection.
Cell Rep Med, 5, 2024
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5YD0
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7Y4F
 | | bacterial DPP4 | | 分子名称: | Dipeptidyl peptidase IV | | 著者 | Hang, J, Jiang, C, Wang, K, Zhang, Z, Guo, F, Liu, J, Wang, G, Lei, X, Gonzalez, F, Qiao, J. | | 登録日 | 2022-06-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.918 Å) | | 主引用文献 | Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.
Science, 381, 2023
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7Y4G
 | | sit-bound btDPP4 | | 分子名称: | (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE, btDPP4 | | 著者 | Hang, J, Jiang, C, Wang, K, Zhang, Z, Guo, F, Liu, J, Wang, G, Lei, X, Gonzalez, F, Qiao, J. | | 登録日 | 2022-06-14 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | | 主引用文献 | Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.
Science, 381, 2023
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7VWV
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6LBS
 | | Crystal structure of yeast Stn1 | | 分子名称: | KLLA0C11825p | | 著者 | Ge, Y, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2019-11-14 | | 公開日 | 2020-07-15 | | 最終更新日 | 2020-08-19 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural insights into telomere protection and homeostasis regulation by yeast CST complex.
Nat.Struct.Mol.Biol., 27, 2020
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6LBR
 | | Crystal structure of yeast Cdc13 and ssDNA | | 分子名称: | KLLA0F20922p, Telomere single-strand DNA | | 著者 | Ge, Y, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2019-11-14 | | 公開日 | 2020-07-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural insights into telomere protection and homeostasis regulation by yeast CST complex.
Nat.Struct.Mol.Biol., 27, 2020
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6LBT
 | | Crystal structure of yeast Cdc13 and Stn1 | | 分子名称: | GLYCEROL, KLLA0C11825p, KLLA0F20922p,KLLA0F20922p | | 著者 | Ge, Y, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2019-11-14 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural insights into telomere protection and homeostasis regulation by yeast CST complex.
Nat.Struct.Mol.Biol., 27, 2020
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6LBU
 | | Crystal structure of yeast Stn1 and Ten1 | | 分子名称: | KLLA0C11825p, KLLA0E09417p | | 著者 | Ge, Y, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2019-11-14 | | 公開日 | 2020-07-15 | | 最終更新日 | 2020-08-19 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into telomere protection and homeostasis regulation by yeast CST complex.
Nat.Struct.Mol.Biol., 27, 2020
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7EMN
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7BR7
 | | Epstein-Barr virus, C1 portal-proximal penton vertex, CATC binding | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | | 著者 | Li, Z, Yu, X. | | 登録日 | 2020-03-26 | | 公開日 | 2020-09-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | CryoEM structure of the tegumented capsid of Epstein-Barr virus.
Cell Res., 30, 2020
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7BR8
 | | Epstein-Barr virus, C5 penton vertex, CATC absent. | | 分子名称: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | | 著者 | Li, Z, Yu, X. | | 登録日 | 2020-03-26 | | 公開日 | 2020-09-30 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | CryoEM structure of the tegumented capsid of Epstein-Barr virus.
Cell Res., 30, 2020
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7BSI
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7BQT
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7BQX
 | | Epstein-Barr virus, C5 portal vertex | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | | 著者 | Li, Z, Yu, X. | | 登録日 | 2020-03-25 | | 公開日 | 2020-09-30 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | CryoEM structure of the tegumented capsid of Epstein-Barr virus.
Cell Res., 30, 2020
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