7Y4G

sit-bound btDPP4

Summary for 7Y4G

• Entry DOI: 10.2210/pdb7y4g/pdb
• Related: 7Y4F 8HAY
• Descriptor: btDPP4, (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE (3 entities in total)
• Functional Keywords: gut microbiota, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Bacteroides thetaiotaomicron
• Total number of polymer chains: 3
• Total formula weight: 247222.90

Authors

Hang, J.,Jiang, C.,Wang, K.,Zhang, Z.,Guo, F.,Liu, J.,Wang, G.,Lei, X.,Gonzalez, F.,Qiao, J. (deposition date: 2022-06-14, release date: 2023-06-14, Last modification date: 2023-08-30)

• Primary citation: Wang, K.,Zhang, Z.,Hang, J.,Liu, J.,Guo, F.,Ding, Y.,Li, M.,Nie, Q.,Lin, J.,Zhuo, Y.,Sun, L.,Luo, X.,Zhong, Q.,Ye, C.,Yun, C.,Zhang, Y.,Wang, J.,Bao, R.,Pang, Y.,Wang, G.,Gonzalez, F.J.,Lei, X.,Qiao, J.,Jiang, C.; Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.; Science, 381:eadd5787-eadd5787, 2023; PubMed: 37535747; DOI: 10.1126/science.add5787

Experimental method

X-RAY DIFFRACTION (1.97 Å)