8HAY

d4-bound btDPP4

Summary for 8HAY

• Entry DOI: 10.2210/pdb8hay/pdb
• Descriptor: btDPP4, (1~{R})-1-[[4-[5-[[(1~{R})-6,7-dimethoxy-2-methyl-3,4-dihydro-1~{H}-isoquinolin-1-yl]methyl]-2-methoxy-phenoxy]phenyl]methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1~{H}-isoquinoline (3 entities in total)
• Functional Keywords: peptidase, gut microbiota, isozyme, secreted, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Bacteroides thetaiotaomicron
• Total number of polymer chains: 4
• Total formula weight: 329405.13

Authors

Hang, J.,Jiang, C.,Wang, K.,Zhang, Z.,Guo, F.,Liu, J.,Wang, G.,Lei, X.,Gonzalez, F.,Qiao, J. (deposition date: 2022-10-27, release date: 2023-07-26, Last modification date: 2023-08-30)

• Primary citation: Wang, K.,Zhang, Z.,Hang, J.,Liu, J.,Guo, F.,Ding, Y.,Li, M.,Nie, Q.,Lin, J.,Zhuo, Y.,Sun, L.,Luo, X.,Zhong, Q.,Ye, C.,Yun, C.,Zhang, Y.,Wang, J.,Bao, R.,Pang, Y.,Wang, G.,Gonzalez, F.J.,Lei, X.,Qiao, J.,Jiang, C.; Microbial-host-isozyme analyses reveal microbial DPP4 as a potential antidiabetic target.; Science, 381:eadd5787-eadd5787, 2023; PubMed: 37535747; DOI: 10.1126/science.add5787

Experimental method

X-RAY DIFFRACTION (2.74 Å)