7RHN
 
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7RHM
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7RMJ
 | | Disulfide stabilized HIV-1 CA hexamer in complex with capsid inhibitor (S)-N-(1-(3-(4-chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-(3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl)acetamide | | 分子名称: | CAPSID PROTEIN P24, CHLORIDE ION, IODIDE ION, ... | | 著者 | Bester, S.M, Kvaratskhelia, M. | | 登録日 | 2021-07-27 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir.
Mbio, 13, 2022
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7RMM
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6U4K
 | | Human talin2 residues 1-403 | | 分子名称: | Talin-2 | | 著者 | Izard, T, Rangarajan, E.S, Colgan, L, Yasuda, R, Chinthalapudi, K. | | 登録日 | 2019-08-26 | | 公開日 | 2020-07-08 | | 最終更新日 | 2020-09-23 | | 実験手法 | X-RAY DIFFRACTION (2.555 Å) | | 主引用文献 | A distinct talin2 structure directs isoform specificity in cell adhesion.
J.Biol.Chem., 295, 2020
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6DKJ
 | | human GIPR ECD and Fab complex | | 分子名称: | 1,2-ETHANEDIOL, Fab heavy chain, Fab light chain, ... | | 著者 | Min, X, Wang, Z. | | 登録日 | 2018-05-29 | | 公開日 | 2019-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.
Sci Transl Med, 10, 2018
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2IFF
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8S9Q
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1BQL
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7SNQ
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6B19
 | | Architecture of HIV-1 reverse transcriptase initiation complex core | | 分子名称: | RNA genome fragment, reverse transcriptase p51 subunit, reverse transcriptase p66 subunit, ... | | 著者 | Larsen, K.P, Mathiharan, Y.K, Chen, D.H, Puglisi, J.D, Skiniotis, G, Puglisi, E.V. | | 登録日 | 2017-09-18 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Architecture of an HIV-1 reverse transcriptase initiation complex.
Nature, 557, 2018
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4ZO5
 | | PDE10 complexed with 4-isopropoxy-2-(2-(3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)isoindoline-1,3-dione | | 分子名称: | 2-{2-[3-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-2-yl]ethyl}-4-(propan-2-yloxy)-1H-isoindole-1,3(2H)-dione, 3-(1-hydroxy-2-methylpropan-2-yl)-5-phenyl-3,5-dihydro-1H-imidazo[4,5-c][1,8]naphthyridine-2,4-dione, MAGNESIUM ION, ... | | 著者 | Yan, Y. | | 登録日 | 2015-05-06 | | 公開日 | 2015-08-12 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Discovery of [(11)C]MK-8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors.
Bioorg.Med.Chem.Lett., 25, 2015
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4CGB
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4CI8
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6I2I
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4NDY
 | | Human MHF1-MHF2 DNA complex | | 分子名称: | Centromere protein S, Centromere protein X, DNA (26-MER) | | 著者 | Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. | | 登録日 | 2013-10-28 | | 公開日 | 2014-01-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (6.999 Å) | | 主引用文献 | The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
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4NE1
 | | Human MHF1 MHF2 DNA complexes | | 分子名称: | Centromere protein S, Centromere protein X, DNA (26-MER) | | 著者 | Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. | | 登録日 | 2013-10-28 | | 公開日 | 2014-01-22 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (6.499 Å) | | 主引用文献 | The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
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4NE3
 | | Human MHF1-MHF2 complex | | 分子名称: | Centromere protein S, Centromere protein X | | 著者 | Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. | | 登録日 | 2013-10-28 | | 公開日 | 2013-12-25 | | 最終更新日 | 2014-02-12 | | 実験手法 | X-RAY DIFFRACTION (1.8007 Å) | | 主引用文献 | The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
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4NE6
 | | Human MHF1-MHF2 complex | | 分子名称: | Centromere protein S, Centromere protein X | | 著者 | Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. | | 登録日 | 2013-10-28 | | 公開日 | 2013-12-25 | | 最終更新日 | 2014-02-12 | | 実験手法 | X-RAY DIFFRACTION (2.1001 Å) | | 主引用文献 | The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
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4NE5
 | | Human MHF1-MHF2 complex | | 分子名称: | Centromere protein S, Centromere protein X | | 著者 | Zhao, Q, Saro, D, Sachpatzidis, A, Sung, P, Xiong, Y. | | 登録日 | 2013-10-28 | | 公開日 | 2013-12-25 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes.
Nat Commun, 5, 2014
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4CGC
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2QKD
 | | Crystal structure of tandem ZPR1 domains | | 分子名称: | FORMIC ACID, ZINC ION, Zinc finger protein ZPR1 | | 著者 | Mishra, A.K. | | 登録日 | 2007-07-10 | | 公開日 | 2007-08-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into the interaction of the evolutionarily conserved ZPR1 domain tandem with eukaryotic EF1A, receptors, and SMN complexes.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2WQO
 | | STRUCTURE OF NEK2 BOUND TO THE AMINOPYRIDINE CCT241950 | | 分子名称: | 4-[2-AMINO-5-(3,4,5-TRIMETHOXYPHENYL)PYRIDIN-3-YL]BENZOIC ACID, CHLORIDE ION, SERINE/THREONINE-PROTEIN KINASE NEK2 | | 著者 | Mas-Droux, C, Bayliss, R. | | 登録日 | 2009-08-24 | | 公開日 | 2009-12-08 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.167 Å) | | 主引用文献 | An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9.
Mol.Cell, 36, 2009
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2WQM
 | | Structure of apo human Nek7 | | 分子名称: | NICKEL (II) ION, SERINE/THREONINE-PROTEIN KINASE NEK7, SULFATE ION | | 著者 | Richards, M.W, Bayliss, R. | | 登録日 | 2009-08-24 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | An Auto-Inhibitory Tyrosine Motif in the Cell-Cycle Regulated Nek7 Kinase is Released Through Binding of Nek9
Mol.Cell, 36, 2009
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2WQN
 | | Structure of ADP-bound human Nek7 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, NICKEL (II) ION, ... | | 著者 | Richards, M.W, Bayliss, R. | | 登録日 | 2009-08-24 | | 公開日 | 2009-12-08 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | An Autoinhibitory Tyrosine Motif in the Cell-Cycle- Regulated Nek7 Kinase is Released Through Binding of Nek9.
Mol.Cell, 36, 2009
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