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1OL5
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BU of 1ol5 by Molmil
Structure of Aurora-A 122-403, phosphorylated on Thr287, Thr288 and bound to TPX2 1-43
分子名称: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, RESTRICTED EXPRESSION PROLIFERATION ASSOCIATED PROTEIN 100, ...
著者Bayliss, R, Conti, E.
登録日2003-08-06
公開日2003-10-30
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle
Mol.Cell, 12, 2003
2C37
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BU of 2c37 by Molmil
RNASE PH CORE OF THE ARCHAEAL EXOSOME IN COMPLEX WITH U8 RNA
分子名称: 5-O-phosphono-beta-D-ribofuranose, CHLORIDE ION, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, ...
著者Lorentzen, E, Conti, E.
登録日2005-10-04
公開日2005-11-23
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core.
Mol.Cell, 20, 2005
1Z3H
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BU of 1z3h by Molmil
The exportin Cse1 in its cargo-free, cytoplasmic state
分子名称: Importin alpha re-exporter, MAGNESIUM ION
著者Cook, A, Fernandez, E, Lindner, D, Ebert, J, Schlenstedt, G, Conti, E.
登録日2005-03-12
公開日2005-05-10
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The structure of the nuclear export receptor cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding
Mol.Cell, 18, 2005
2C38
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BU of 2c38 by Molmil
RNase PH core of the archaeal exosome in complex with A5 RNA
分子名称: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, PROBABLE EXOSOME COMPLEX EXONUCLEASE 1, ...
著者Lorentzen, E, Conti, E.
登録日2005-10-04
公開日2005-11-23
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structural Basis of 3' End RNA Recognition and Exoribonucleolytic Cleavage by an Exosome Rnase Ph Core.
Mol.Cell, 20, 2005
4IFD
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BU of 4ifd by Molmil
Crystal structure of an 11-subunit eukaryotic exosome complex bound to RNA
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, BROMIDE ION, Exosome complex component CSL4, ...
著者Makino, D.L, Conti, E.
登録日2012-12-14
公開日2013-02-06
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.805 Å)
主引用文献Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex.
Nature, 495, 2013
4JHK
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BU of 4jhk by Molmil
Crystal structure of Danio rerio SLIP1 in complex with SLBP
分子名称: MIF4G domain-containing protein B, SULFATE ION, Sb:cb157 protein
著者von Moeller, H, Conti, E.
登録日2013-03-05
公開日2013-07-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.507 Å)
主引用文献Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.
Nucleic Acids Res., 41, 2013
4JHJ
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BU of 4jhj by Molmil
Crystal structure of Danio rerio Slip1 in complex with Dbp5
分子名称: DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 19 (DBP5 homolog, yeast), MIF4G domain-containing protein B
著者Von Moeller, H, Conti, E.
登録日2013-03-05
公開日2013-07-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.
Nucleic Acids Res., 41, 2013
2HWX
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BU of 2hwx by Molmil
Structure of human SMG6 E1282C PIN domain mutant.
分子名称: Telomerase-binding protein EST1A
著者Glavan, F, Behm-Ansmant, I, Izaurralde, E, Conti, E.
登録日2006-08-02
公開日2006-11-14
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Embo J., 25, 2006
2HWW
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BU of 2hww by Molmil
Structure of PIN domain of human SMG6
分子名称: Telomerase-binding protein EST1A
著者Glavan, F, Behm-Ansmant, I, Izaurralde, E, Conti, E.
登録日2006-08-02
公開日2006-11-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Embo J., 25, 2006
2HWY
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BU of 2hwy by Molmil
Structure of PIN domain of human SMG5.
分子名称: Protein SMG5
著者Glavan, F, Behm-Ansmant, I, Izaurralde, E, Conti, E.
登録日2006-08-02
公開日2006-11-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex.
Embo J., 25, 2006
7PW8
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BU of 7pw8 by Molmil
Human SMG1-8-9 kinase complex bound to AMPPNP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (2.82 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW4
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BU of 7pw4 by Molmil
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor
分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.27 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW9
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BU of 7pw9 by Molmil
Human SMG1-9 kinase complex bound to AMPPNP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW5
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BU of 7pw5 by Molmil
Human SMG1-8-9 kinase complex with AlphaFold predicted SMG8 C-terminus, bound to a SMG1 inhibitor
分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
最終更新日2025-07-09
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW6
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BU of 7pw6 by Molmil
Human SMG1-8-9 kinase complex bound to a SMG1 inhibitor - SMG1 body
分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, INOSITOL HEXAKISPHOSPHATE, Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1,Serine/threonine-protein kinase SMG1
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7PW7
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BU of 7pw7 by Molmil
Human SMG1-9 kinase complex bound to a SMG1 inhibitor
分子名称: 1-[4-[4-[2-[[4-chloranyl-3-(diethylsulfamoyl)phenyl]amino]pyrimidin-4-yl]pyridin-2-yl]phenyl]-3-methyl-urea, ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ...
著者Langer, L.M, Conti, E.
登録日2021-10-06
公開日2021-12-01
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8.
Elife, 10, 2021
7QDZ
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BU of 7qdz by Molmil
80S-bound human SKI complex in the closed state
分子名称: Helicase SKI2W, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3'), Tetratricopeptide repeat protein 37, ...
著者Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E.
登録日2021-12-01
公開日2022-02-09
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
Mol.Cell, 82, 2022
7QE0
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BU of 7qe0 by Molmil
80S-bound human SKI complex in the open state
分子名称: Helicase SKI2W, RNA (5'-R(P*UP*UP*UP*UP*UP*UP*UP*UP*U)-3')
著者Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E.
登録日2021-12-01
公開日2022-02-09
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
Mol.Cell, 82, 2022
7QDS
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BU of 7qds by Molmil
Apo human SKI complex in the open state
分子名称: Helicase SKI2W, Tetratricopeptide repeat protein 37, WD repeat-containing protein 61
著者Koegel, A, Keidel, A, Bonneau, A, Schaefer, I.B, Conti, E.
登録日2021-11-30
公開日2022-02-02
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
Mol.Cell, 82, 2022
7QDR
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BU of 7qdr by Molmil
Apo human SKI complex in the closed state
分子名称: Helicase SKI2W, Tetratricopeptide repeat protein 37, WD repeat-containing protein 61
著者Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E.
登録日2021-11-29
公開日2022-02-02
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
Mol.Cell, 82, 2022
7QDY
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BU of 7qdy by Molmil
RNA-bound human SKI complex
分子名称: Helicase SKI2W, RNA (5'-R(P*UP*UP*UP*UP*UP*U)-3'), Tetratricopeptide repeat protein 37, ...
著者Koegel, A, Keidel, A, Bonneau, F, Schaefer, I.B, Conti, E.
登録日2021-12-01
公開日2022-02-09
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献The human SKI complex regulates channeling of ribosome-bound RNA to the exosome via an intrinsic gatekeeping mechanism.
Mol.Cell, 82, 2022
1OF5
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BU of 1of5 by Molmil
Crystal structure of Mex67-Mtr2
分子名称: MERCURY (II) ION, MRNA EXPORT FACTOR MEX67, MRNA TRANSPORT REGULATOR MTR2
著者Fribourg, S, Conti, E.
登録日2003-04-08
公開日2003-07-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural similarity in the absence of sequence homology of the messenger RNA export factors Mtr2 and p15.
EMBO Rep., 4, 2003
1OL6
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BU of 1ol6 by Molmil
Structure of unphosphorylated D274N mutant of Aurora-A
分子名称: ADENOSINE-5'-TRIPHOSPHATE, SERINE/THREONINE KINASE 6
著者Bayliss, R, Conti, E.
登録日2003-08-06
公開日2003-10-30
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis of Aurora-A Activation by Tpx2 at the Mitotic Spindle.
Mol.Cell, 12, 2003
4ZKE
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BU of 4zke by Molmil
Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GTP.
分子名称: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, SODIUM ION, ...
著者Kowalinski, E, Conti, E.
登録日2015-04-30
公開日2015-06-17
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.251 Å)
主引用文献Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
Structure, 23, 2015
4ZKD
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BU of 4zkd by Molmil
Crystal structure of the S. cerevisiae Ski7 GTPase-like domain, bound to GDP and inorganic phosphate.
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
著者Kowalinski, E, Conti, E.
登録日2015-04-30
公開日2015-06-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.181 Å)
主引用文献Saccharomyces cerevisiae Ski7 Is a GTP-Binding Protein Adopting the Characteristic Conformation of Active Translational GTPases.
Structure, 23, 2015

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