6SLV
 
 | | Fragment AZ-013 binding at the p53pT387/14-3-3 sigma interface | | 分子名称: | 14-3-3 protein sigma, 4-(methylamino)-7-propan-2-yloxy-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... | | 著者 | Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. | | 登録日 | 2019-08-20 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
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6SLX
 | | Fragment AZ-010 binding at the TAZpS89/14-3-3 sigma interface | | 分子名称: | 14-3-3 protein sigma, TAZpS89, ~{N}-[3-(5-carbamimidoylthiophen-3-yl)phenyl]propanamide | | 著者 | Ottmann, C, Wolter, M, Guillory, X, Genet, S, Somsen, B, Leysen, S, Castaldi, P. | | 登録日 | 2019-08-20 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.800045 Å) | | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
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6SLW
 | | Fragment AZ-004 binding at the TAZpS89/14-3-3 sigma interface | | 分子名称: | 14-3-3 protein sigma, 4-methyl-5-phenyl-thiophene-2-carboximidamide, WW domain-containing transcription regulator protein 1 | | 著者 | Ottmann, C, Wolter, M, Guillory, X, Leysen, S, Genet, S, Somsen, B, Patel, J, Castaldi, P. | | 登録日 | 2019-08-20 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
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6RP6
 | | Fragment AZ-019 binding at the TAZpS89/14-3-3 sigma interface | | 分子名称: | 14-3-3 protein sigma, 4-phenyl-5-(piperidin-4-ylmethyl)thiophene-2-carboximidamide, CALCIUM ION, ... | | 著者 | Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. | | 登録日 | 2019-05-14 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.885 Å) | | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
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6SIO
 | | Fragment AZ-017 binding at the p53pT387/14-3-3 sigma interface | | 分子名称: | 14-3-3 protein sigma, 5-methyl-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... | | 著者 | Leysen, S, Wolter, M, Guillory, X, Genet, S, Somsen, B, Patel, J, Castaldi, P, Ottmann, C. | | 登録日 | 2019-08-10 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.60418 Å) | | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces.
J.Med.Chem., 63, 2020
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3NR2
 | | Crystal structure of Caspase-6 zymogen | | 分子名称: | Caspase-6 | | 著者 | Su, X.-D, Wang, X.-J, Liu, X, Mi, W, Wang, K.-T. | | 登録日 | 2010-06-30 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structures of human caspase 6 reveal a new mechanism for intramolecular cleavage self-activation
Embo Rep., 11, 2010
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7SP1
 | | RNA-induced tau amyloid fibril | | 分子名称: | Isoform Tau-F of Microtubule-associated protein tau, RNA (5'-R(*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3') | | 著者 | Abskharon, R, Sawaya, M.R, Boyer, D.R, Eisenberg, D.S. | | 登録日 | 2021-11-02 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Cryo-EM structure of RNA-induced tau fibrils reveals a small C-terminal core that may nucleate fibril formation.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8H03
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8H04
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8H05
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5WIA
 | | Crystal structure of the segment, GNNSYS, from the low complexity domain of TDP-43, residues 370-375 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Trinh, H, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2017-07-18 | | 公開日 | 2018-04-25 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.002 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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5WKD
 | | Crystal structure of the segment, GNNQGSN, from the low complexity domain of TDP-43, residues 300-306 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Trinh, H, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2017-07-25 | | 公開日 | 2018-04-18 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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5WHN
 | | Crystal structure of the segment, NFGAFS, from the low complexity domain of TDP-43, residues 312-317 | | 分子名称: | Segment of TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2017-07-17 | | 公開日 | 2018-04-25 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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5WHP
 | | Crystal structure of the segment, NFGTFS, from the A315T familial variant of the low complexity domain of TDP-43, residues 312-317 | | 分子名称: | Segment of TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2017-07-17 | | 公開日 | 2018-05-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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5WIQ
 | | Crystal structure of the segment, GFNGGFG, from the low complexity domain of TDP-43, residues 396-402 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Sawaya, M.R, Eisenberg, D.S. | | 登録日 | 2017-07-19 | | 公開日 | 2018-04-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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5WKB
 | | MicroED structure of the segment, NFGEFS, from the A315E familial variant of the low complexity domain of TDP-43, residues 312-317 | | 分子名称: | TAR DNA-binding protein 43 | | 著者 | Guenther, E.L, Sawaya, M.R, Cascio, D, Eisenberg, D.S. | | 登録日 | 2017-07-24 | | 公開日 | 2018-05-23 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1 Å) | | 主引用文献 | Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
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6CFH
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5G5J
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7XO2
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7XO3
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7XO0
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7XO1
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7E0F
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7VQQ
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