6PLW
| CryoEM structure of zebra fish alpha-1 glycine receptor bound with GABA in SMA, super-open state | 分子名称: | GAMMA-AMINO-BUTANOIC ACID, Glycine receptor subunit alphaZ1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Yu, J, Zhu, H, Gouaux, E. | 登録日 | 2019-07-01 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Mechanism of gating and partial agonist action in the glycine receptor. Cell, 184, 2021
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6QF8
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6QFP
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6QH2
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1CEH
| STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER | 分子名称: | CALCIUM ION, PHOSPHOLIPASE A2 | 著者 | Kumar, A, Sekharudu, C, Ramakrishnan, B, Dupureur, C.M, Zhu, H, Tsai, M.-D, Sundaralingam, M. | 登録日 | 1994-11-16 | 公開日 | 1995-02-07 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure and function of the catalytic site mutant Asp 99 Asn of phospholipase A2: absence of the conserved structural water. Protein Sci., 3, 1994
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1EJ8
| CRYSTAL STRUCTURE OF DOMAIN 2 OF THE YEAST COPPER CHAPERONE FOR SUPEROXIDE DISMUTASE (LYS7) AT 1.55 A RESOLUTION | 分子名称: | CALCIUM ION, LYS7 | 著者 | Hall, L.T, Sanchez, R.J, Holloway, S.P, Zhu, H, Stine, J.E, Lyons, T.J, Demeler, B, Schirf, V, Hansen, J.C, Nersissian, A.M, Valentine, J.S, Hart, P.J. | 登録日 | 2000-03-01 | 公開日 | 2000-04-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | X-ray crystallographic and analytical ultracentrifugation analyses of truncated and full-length yeast copper chaperones for SOD (LYS7): a dimer-dimer model of LYS7-SOD association and copper delivery. Biochemistry, 39, 2000
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8EFC
| Structure of Lates calcarifer DNA polymerase theta polymerase domain with long duplex DNA, complex Ia | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*CP*TP*GP*TP*GP*AP*GP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*CP*CP*TP*CP*AP*CP*AP*G)-3'), ... | 著者 | Li, C, Zhu, H, Sun, J, Gao, Y. | 登録日 | 2022-09-08 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
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8EFK
| Structure of Lates calcarifer DNA polymerase theta polymerase domain with hairpin DNA | 分子名称: | 2',3'-dideoxyadenosine triphosphate, DNA (5'-D(P*TP*TP*TP*TP*GP*GP*CP*TP*TP*TP*TP*GP*CP*CP*(2DA))-3'), Lates calcarifer DNA polymerase theta, ... | 著者 | Li, C, Zhu, H, Sun, J, Gao, Y. | 登録日 | 2022-09-08 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
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8EF9
| Structure of Lates calcarifer DNA polymerase theta polymerase domain with long duplex DNA, complex Ia | 分子名称: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*GP*CP*AP*TP*CP*CP*GP*TP*AP*GP*(2DA))-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*AP*CP*GP*GP*AP*TP*GP*C)-3'), ... | 著者 | Li, C, Zhu, H, Sun, J, Gao, Y. | 登録日 | 2022-09-08 | 公開日 | 2022-12-14 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural basis of DNA polymerase theta mediated DNA end joining. Nucleic Acids Res., 51, 2023
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6NJE
| Crystal structure of the motor domain of human kinesin family member 22 | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, Kinesin-like protein KIF22, ... | 著者 | Walker, B.C, Zhu, H, Tempel, W, Arrowsmith, C.H, Edwards, A.M, Park, H, Cochran, J.C, Structural Genomics Consortium (SGC) | 登録日 | 2019-01-03 | 公開日 | 2019-01-16 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of the motor domain of human kinesin family member 22 To Be Published
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7LI3
| Structure of the LRRK2 G2019S mutant | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Myasnikov, A, Zhu, H, Hixson, P, Xie, B, Yu, K, Pitre, A, Peng, J, Sun, J. | 登録日 | 2021-01-26 | 公開日 | 2021-06-16 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural analysis of the full-length human LRRK2. Cell, 184, 2021
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7LI4
| Structure of LRRK2 after symmetry expansion | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Myasnikov, A, Zhu, H, Hixson, P, Xie, B, Yu, K, Pitre, A, Peng, J, Sun, J. | 登録日 | 2021-01-26 | 公開日 | 2021-06-16 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural analysis of the full-length human LRRK2. Cell, 184, 2021
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7LHT
| Structure of the LRRK2 dimer | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Myasnikov, A, Zhu, H, Hixson, P, Xie, B, Yu, K, Pitre, A, Peng, J, Sun, J. | 登録日 | 2021-01-26 | 公開日 | 2021-06-16 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural analysis of the full-length human LRRK2. Cell, 184, 2021
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7LHW
| Structure of the LRRK2 monomer | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Myasnikov, A, Zhu, H, Hixson, P, Xie, B, Yu, K, Pitre, A, Peng, J, Sun, J. | 登録日 | 2021-01-26 | 公開日 | 2021-06-16 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural analysis of the full-length human LRRK2. Cell, 184, 2021
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3V1S
| Scaffold tailoring by a newly detected Pictet-Spenglerase ac-tivity of strictosidine synthase (STR1): from the common tryp-toline skeleton to the rare piperazino-indole framework | 分子名称: | 2-(1H-indol-1-yl)ethanamine, Strictosidine synthase | 著者 | Wu, F, Zhu, H, Sun, L, Rajendran, C, Wang, M, Ren, X, Panjikar, S, Cherkasov, A, Zou, H, Stoeckigt, J. | 登録日 | 2011-12-10 | 公開日 | 2012-02-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.328 Å) | 主引用文献 | Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework J.Am.Chem.Soc., 134, 2012
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8ISY
| Cryo-EM structure of free-state Crt-SPARTA | 分子名称: | Piwi domain-containing protein, TIR domain-containing protein | 著者 | Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. | 登録日 | 2023-03-21 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
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8ISZ
| Cryo-EM structure of Crt-SPARTA-gRNA-tDNA monomer | 分子名称: | DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... | 著者 | Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. | 登録日 | 2023-03-21 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
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8IT0
| Cryo-EM structure of Crt-SPARTA-gRNA-tDNA dimer (conformation-2) | 分子名称: | DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... | 著者 | Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. | 登録日 | 2023-03-21 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
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8IT1
| Cryo-EM structure of Crt-SPARTA-gRNA-tDNA tetramer (NADase active form) | 分子名称: | DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... | 著者 | Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. | 登録日 | 2023-03-21 | 公開日 | 2023-11-08 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
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8K9G
| Cryo-EM structure of Crt-SPARTA-gRNA-tDNA dimer (conformation-1) | 分子名称: | DNA (45-mer), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*GP*GP*UP*AP*GP*UP*AP*GP*GP*UP*UP*GP*UP*AP*UP*AP*GP*U)-3'), ... | 著者 | Gao, X, Shang, K, Zhu, K, Wang, L, Mu, Z, Fu, X, Yu, X, Qin, B, Zhu, H, Ding, W, Cui, S. | 登録日 | 2023-08-01 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Nucleic-acid-triggered NADase activation of a short prokaryotic Argonaute. Nature, 625, 2024
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4IQ6
| Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine | 分子名称: | 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine, Glycogen synthase kinase-3 beta | 著者 | Tong, Y, Stewart, K.D, Florjancic, A.S, Harlan, J.E, Merta, P.J, Przytulinska, M, Soni, N, Swinger, K.S, Zhu, H, Johnson, E.F, Shoemaker, A.R, Penning, T.D. | 登録日 | 2013-01-10 | 公開日 | 2013-04-24 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195. ACS Med Chem Lett, 4, 2013
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5U8F
| Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine | 分子名称: | (3R,4S)-1-[(1S)-7-fluoro-2,3-dihydro-1H-inden-1-yl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine, Polycomb protein EED | 著者 | Jakob, C.G, Zhu, H. | 登録日 | 2016-12-14 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.343 Å) | 主引用文献 | SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg. Med. Chem. Lett., 27, 2017
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5U8A
| Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-bromo-6-fluorophenyl)methyl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine | 分子名称: | (3R,4S)-1-[(2-bromo-6-fluorophenyl)methyl]-N,N-dimethyl-4-(1-methyl-1H-indol-3-yl)pyrrolidin-3-amine, Polycomb protein EED | 著者 | Jakob, C.G, Zhu, H. | 登録日 | 2016-12-14 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg. Med. Chem. Lett., 27, 2017
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5U6D
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5U69
| Polycomb protein EED in complex with inhibitor: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine | 分子名称: | (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine, Polycomb protein EED | 著者 | Jakob, C.G, Zhu, H. | 登録日 | 2016-12-07 | 公開日 | 2017-03-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding. Bioorg. Med. Chem. Lett., 27, 2017
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