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5U6D

Polycomb protein EED in complex with inhibitor: 2-[4-(4-{(3S,4R)-4-(dimethylamino)-1-[(2-fluoro-6-methylphenyl)methyl]pyrrolidin-3-yl}phenyl)-1H-pyrazol-1-yl]acetamide

Summary for 5U6D
Entry DOI10.2210/pdb5u6d/pdb
Related5U69
DescriptorPolycomb protein EED, 2-[4-(4-{(3S,4R)-4-(dimethylamino)-1-[(2-fluoro-6-methylphenyl)methyl]pyrrolidin-3-yl}phenyl)-1H-pyrazol-1-yl]acetamide (3 entities in total)
Functional Keywordswd40 prc2, protein binding, inhibitor
Biological sourceHomo sapiens (Human)
Cellular locationNucleus: O75530
Total number of polymer chains1
Total formula weight43019.02
Authors
Jakob, C.G.,Zhu, H. (deposition date: 2016-12-07, release date: 2017-03-15, Last modification date: 2023-10-04)
Primary citationCurtin, M.L.,Pliushchev, M.A.,Li, H.Q.,Torrent, M.,Dietrich, J.D.,Jakob, C.G.,Zhu, H.,Zhao, H.,Wang, Y.,Ji, Z.,Clark, R.F.,Sarris, K.A.,Selvaraju, S.,Shaw, B.,Algire, M.A.,He, Y.,Richardson, P.L.,Sweis, R.F.,Sun, C.,Chiang, G.G.,Michaelides, M.R.
SAR of amino pyrrolidines as potent and novel protein-protein interaction inhibitors of the PRC2 complex through EED binding.
Bioorg. Med. Chem. Lett., 27:1576-1583, 2017
Cited by
PubMed: 28254486
DOI: 10.1016/j.bmcl.2017.02.030
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.64 Å)
Structure validation

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