5U6D

Polycomb protein EED in complex with inhibitor: 2-[4-(4-{(3S,4R)-4-(dimethylamino)-1-[(2-fluoro-6-methylphenyl)methyl]pyrrolidin-3-yl}phenyl)-1H-pyrazol-1-yl]acetamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016571	biological_process	histone methylation
A	0035098	cellular_component	ESC/E(Z) complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	binding site for residue 7XG A 501

Chain	Residue
A	PRO95
A	ARG414
A	ASP430
A	HOH654
A	PHE97
A	TYR148
A	ASN194
A	GLU238
A	LEU240
A	ASP310
A	TYR365
A	ARG367

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI

Chain	Residue	Details
A	LEU206-ILE220

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:20974918

Chain	Residue	Details
A	LYS197
A	LYS268
A	LYS284

---