4IQ6
Gsk-3beta with inhibitor 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine
Summary for 4IQ6
Entry DOI | 10.2210/pdb4iq6/pdb |
Descriptor | Glycogen synthase kinase-3 beta, 6-chloro-N-cyclohexyl-4-(1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2-amine (2 entities in total) |
Functional Keywords | protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P49841 |
Total number of polymer chains | 2 |
Total formula weight | 95339.27 |
Authors | Tong, Y.,Stewart, K.D.,Florjancic, A.S.,Harlan, J.E.,Merta, P.J.,Przytulinska, M.,Soni, N.,Swinger, K.S.,Zhu, H.,Johnson, E.F.,Shoemaker, A.R.,Penning, T.D. (deposition date: 2013-01-10, release date: 2013-04-24, Last modification date: 2024-02-28) |
Primary citation | Tong, Y.,Stewart, K.D.,Florjancic, A.S.,Harlan, J.E.,Merta, P.J.,Przytulinska, M.,Soni, N.,Swinger, K.K.,Zhu, H.,Johnson, E.F.,Shoemaker, A.R.,Penning, T.D. Azaindole-Based Inhibitors of Cdc7 Kinase: Impact of the Pre-DFG Residue, Val 195. ACS Med Chem Lett, 4:211-215, 2013 Cited by PubMed: 24900653DOI: 10.1021/ml300348c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.12 Å) |
Structure validation
Download full validation report