8BJT
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![BU of 8bjt by Molmil](/molmil-images/mine/8bjt) | Structure of human PLK1 in complex with 2-Allyl-1-[6-(1-hydroxy-1-methyl-ethyl)-pyridin-2-yl]-6-[4-(4-methyl-piperazin-1-yl)-phenylamino]-1,2-dihydro-pyrazolo[3,4-d]pyrimidin-3-one | 分子名称: | 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, ACETATE ION, Serine/threonine-protein kinase PLK1, ... | 著者 | Musil, D, Liu-Bujalski, L. | 登録日 | 2022-11-06 | 公開日 | 2023-04-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.188 Å) | 主引用文献 | Selective Wee1 Inhibitors Led to Antitumor Activity In Vitro and Correlated with Myelosuppression. Acs Med.Chem.Lett., 14, 2023
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8BJU
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5X5O
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![BU of 5x5o by Molmil](/molmil-images/mine/5x5o) | Crystal structure of ZAK in complex with compound D2829 | 分子名称: | Mitogen-activated protein kinase kinase kinase MLT, N-[2,4-bis(fluoranyl)-3-[2-(3-methoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]phenyl]-3-bromanyl-benzenesulfonamide | 著者 | Dai, Y.B, Zhao, P, Yun, C.H. | 登録日 | 2017-02-17 | 公開日 | 2017-12-27 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.868 Å) | 主引用文献 | Structure Based Design of N-(3-((1H-Pyrazolo[3,4-b]pyridin-5-yl)ethynyl)benzenesulfonamides as Selective Leucine-Zipper and Sterile-alpha Motif Kinase (ZAK) Inhibitors. J. Med. Chem., 60, 2017
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3P0H
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![BU of 3p0h by Molmil](/molmil-images/mine/3p0h) | Leishmania major Tyrosyl-tRNA synthetase in complex with fisetin, cubic crystal form | 分子名称: | 3,7,3',4'-TETRAHYDROXYFLAVONE, Tyrosyl-tRNA synthetase | 著者 | Larson, E.T, Merritt, E.A, Medical Structural Genomics of Pathogenic Protozoa (MSGPP) | 登録日 | 2010-09-28 | 公開日 | 2011-03-23 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | The Double-Length Tyrosyl-tRNA Synthetase from the Eukaryote Leishmania major Forms an Intrinsically Asymmetric Pseudo-Dimer. J.Mol.Biol., 409, 2011
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3P0J
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7C2L
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![BU of 7c2l by Molmil](/molmil-images/mine/7c2l) | S protein of SARS-CoV-2 in complex bound with 4A8 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Yan, R.H, Zhang, Y.Y, Guo, Y.Y, Li, Y.N, Xia, L, Zhou, Q. | 登録日 | 2020-05-08 | 公開日 | 2020-07-01 | 最終更新日 | 2021-02-17 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2. Science, 369, 2020
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3P0I
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3NEG
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3NEF
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![BU of 3nef by Molmil](/molmil-images/mine/3nef) | High-resolution pyrabactin-bound PYL1 structure | 分子名称: | 4-bromo-N-(pyridin-2-ylmethyl)naphthalene-1-sulfonamide, Abscisic acid receptor PYL1 | 著者 | Yan, N. | 登録日 | 2010-06-08 | 公開日 | 2010-06-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Functional mechanism of the ABA agonist pyrabactin J.Biol.Chem., 285, 2010
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6LS9
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![BU of 6ls9 by Molmil](/molmil-images/mine/6ls9) | Crystal structure of bovine herpesvirus 1 glycoprotein D | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein D | 著者 | Yue, D, Chen, Z.J, Yang, F.L, Ye, F, Lin, S, Cheng, Y.W, Wang, J.C, Chen, Z.M, Lin, X, Yang, J, Chen, H, Zhang, Z.L, You, Y, Sun, H.L, Wen, A, Wang, L.L, Zheng, Y, Cao, Y, Li, Y.H, Lu, G.W. | 登録日 | 2020-01-17 | 公開日 | 2020-06-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | 主引用文献 | Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor. Sci Adv, 6, 2020
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5LGG
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![BU of 5lgg by Molmil](/molmil-images/mine/5lgg) | The N-terminal WD40 domain of Apc1 (Anaphase promoting complex subunit 1) | 分子名称: | Anaphase-promoting complex subunit 1,Anaphase-promoting complex subunit 1,Anaphase-promoting complex subunit 1,Anaphase-promoting complex subunit 1 | 著者 | Li, Q, Aibara, S, Barford, D. | 登録日 | 2016-07-07 | 公開日 | 2016-10-05 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | WD40 domain of Apc1 is critical for the coactivator-induced allosteric transition that stimulates APC/C catalytic activity. Proc.Natl.Acad.Sci.USA, 113, 2016
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5GJU
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![BU of 5gju by Molmil](/molmil-images/mine/5gju) | DEAD-box RNA helicase | 分子名称: | ADENOSINE MONOPHOSPHATE, ATP-dependent RNA helicase DeaD | 著者 | Xu, L, Li, F, Wang, L, Shi, Y. | 登録日 | 2016-07-02 | 公開日 | 2017-05-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions. Structure, 25, 2017
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5GI4
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![BU of 5gi4 by Molmil](/molmil-images/mine/5gi4) | DEAD-box RNA helicase | 分子名称: | ATP-dependent RNA helicase DeaD | 著者 | Xu, L, Wang, L, Li, F, Wu, L, Shi, Y. | 登録日 | 2016-06-22 | 公開日 | 2017-05-31 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.244 Å) | 主引用文献 | Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions. Structure, 25, 2017
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7CHO
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![BU of 7cho by Molmil](/molmil-images/mine/7cho) | Crystal structure of SARS-CoV-2 antibody P5A-1D2 with RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody P5A-1D2 heavy chain, ... | 著者 | Wang, X, Zhang, L, Ge, J, Wang, R, Zhang, Q. | 登録日 | 2020-07-06 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.561 Å) | 主引用文献 | Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun, 12, 2021
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7CHS
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![BU of 7chs by Molmil](/molmil-images/mine/7chs) | Crystal structure of SARS-CoV-2 antibody P22A-1D1 with RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody P22A-1D1 heavy chain, ... | 著者 | Wang, X, Zhang, L, Ge, J, Wang, R, Zhang, Q. | 登録日 | 2020-07-06 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | 主引用文献 | Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun, 12, 2021
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7CHP
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![BU of 7chp by Molmil](/molmil-images/mine/7chp) | Crystal structure of SARS-CoV-2 antibody P5A-3C8 with RBD | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody P5A-3C8 heavy chain, ... | 著者 | Wang, X, Zhang, L, Ge, J, Wang, R, Zhang, Q. | 登録日 | 2020-07-06 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.357 Å) | 主引用文献 | Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2. Nat Commun, 12, 2021
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3F6G
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![BU of 3f6g by Molmil](/molmil-images/mine/3f6g) | Crystal structure of the regulatory domain of LiCMS in complexed with isoleucine - type II | 分子名称: | Alpha-isopropylmalate synthase, ISOLEUCINE, SULFATE ION, ... | 著者 | Zhang, P, Ma, J, Zhao, G, Ding, J. | 登録日 | 2008-11-06 | 公開日 | 2009-04-21 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans Biochem.J., 421, 2009
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3F6H
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![BU of 3f6h by Molmil](/molmil-images/mine/3f6h) | Crystal structure of the regulatory domain of LiCMS in complexed with isoleucine - type III | 分子名称: | Alpha-isopropylmalate synthase, ISOLEUCINE, ZINC ION | 著者 | Zhang, P, Ma, J, Zhao, G, Ding, J. | 登録日 | 2008-11-06 | 公開日 | 2009-04-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular basis of the inhibitor selectivity and insights into the feedback inhibition mechanism of citramalate synthase from Leptospira interrogans Biochem.J., 421, 2009
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6ZY9
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![BU of 6zy9 by Molmil](/molmil-images/mine/6zy9) | Cryo-EM structure of MlaFEDB in complex with AMP-PNP | 分子名称: | ABC transporter maintaining OM lipid asymmetry, cytoplasmic STAS component, MAGNESIUM ION, ... | 著者 | Dong, C.J, Dong, H.H. | 登録日 | 2020-07-30 | 公開日 | 2020-11-25 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural insights into outer membrane asymmetry maintenance in Gram-negative bacteria by MlaFEDB. Nat.Struct.Mol.Biol., 28, 2021
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7ARM
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![BU of 7arm by Molmil](/molmil-images/mine/7arm) | LolCDE in complex with lipoprotein and LolA | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, LPP, Lipoprotein-releasing ABC transporter permease subunit LolC, ... | 著者 | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Shen, C.R, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Wei, X.W, Dong, C.J, Zhang, X, Dong, H.H. | 登録日 | 2020-10-25 | 公開日 | 2021-04-07 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARL
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![BU of 7arl by Molmil](/molmil-images/mine/7arl) | LolCDE in complex with lipoprotein and ADP | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, ADENOSINE-5'-DIPHOSPHATE, LPP, ... | 著者 | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Shen, C.R, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Wei, X.W, Dong, C.J, Zhang, X, Dong, H.H. | 登録日 | 2020-10-25 | 公開日 | 2021-04-07 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARK
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![BU of 7ark by Molmil](/molmil-images/mine/7ark) | LolCDE in complex with AMP-PNP in the closed NBD state | 分子名称: | Lipoprotein-releasing ABC transporter permease subunit LolC, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolE, ... | 著者 | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Dong, C.J, Zhang, X, Dong, H.H. | 登録日 | 2020-10-25 | 公開日 | 2021-04-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARJ
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![BU of 7arj by Molmil](/molmil-images/mine/7arj) | LolCDE in complex with lipoprotein and AMPPNP complex undimerized form | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, LPP, Lipoprotein-releasing ABC transporter permease subunit LolC, ... | 著者 | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Dong, C.J, Zhang, X, Dong, H.H. | 登録日 | 2020-10-25 | 公開日 | 2021-04-07 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARI
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![BU of 7ari by Molmil](/molmil-images/mine/7ari) | LolCDE apo structure | 分子名称: | Lipoprotein-releasing ABC transporter permease subunit LolC, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein LolE | 著者 | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Dong, C.J, Zhang, X, Dong, H.H. | 登録日 | 2020-10-25 | 公開日 | 2021-04-07 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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7ARH
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![BU of 7arh by Molmil](/molmil-images/mine/7arh) | LolCDE in complex with lipoprotein | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, LPP, Lipoprotein-releasing ABC transporter permease subunit LolC, ... | 著者 | Tang, X.D, Chang, S.H, Zhang, K, Wang, T, Luo, Q.H, Qiao, W, Wang, C, Zhang, Z.B, Zhang, Z.Y, Zhu, X.F, Dong, C.J, Zhang, X, Dong, H.H. | 登録日 | 2020-10-25 | 公開日 | 2021-04-07 | 最終更新日 | 2021-04-28 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis for bacterial lipoprotein relocation by the transporter LolCDE. Nat.Struct.Mol.Biol., 28, 2021
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