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CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb36
分子名称:	Nanobody Nb21, Nanobody Nb36, Spike protein S1
著者	Huang, W, Taylor, D.J.
登録日	2021-04-06
公開日	2021-08-11
実験手法	ELECTRON MICROSCOPY (3.55 Å)
主引用文献	Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes Nat Commun, 12, 2021

7MDW

CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb21 and Nb105
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, nanobody Nb105, ...
著者	Huang, W, Taylor, D.J.
登録日	2021-04-06
公開日	2021-08-11
実験手法	ELECTRON MICROSCOPY (3.58 Å)
主引用文献	Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes Nat Commun, 12, 2021

7ME7

CryoEM structure of SARS-CoV-2 RBD in complex with nanobodies Nb17 and Nb105
分子名称:	Nanobody Nb105, Nanobody Nb17, Spike protein S1
著者	Huang, W, Taylor, D.J.
登録日	2021-04-06
公開日	2021-08-11
実験手法	ELECTRON MICROSCOPY (3.73 Å)
主引用文献	Potent neutralizing nanobodies resist convergent circulating variants of SARS-CoV-2 by targeting diverse and conserved epitopes Nat Commun, 12, 2021

6LZZ

Crystal structure of the PDE9 catalytic domain in complex with inhibitor 4a
分子名称:	1-cyclopentyl-6-[[(2R)-1-(2-oxa-6-azaspiro[3.3]heptan-6-yl)-1-oxidanylidene-propan-2-yl]amino]-5H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ...
著者	Huang, Y.Y, Wu, Y, Luo, H.B.
登録日	2020-02-19
公開日	2021-02-24
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (2.40003753 Å)
主引用文献	Identification of phosphodiesterase-9 as a novel target for pulmonary arterial hypertension by using highly selective and orally bioavailable inhibitors To Be Published

5Y37

Crystal structure of GBS GAPDH
分子名称:	Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
著者	Jin, T, Zhou, K.
登録日	2017-07-28
公開日	2018-04-18
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.36 Å)
主引用文献	High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr.,Sect.F, 74, 2018

1RKB

The structure of adrenal gland protein AD-004
分子名称:	LITHIUM ION, Protein AD-004, SULFATE ION
著者	Ren, H, Liang, Y, Bennett, M, Su, X.D.
登録日	2003-11-21
公開日	2005-01-11
最終更新日	2024-03-13
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus Proc.Natl.Acad.Sci.Usa, 102, 2005

6N33

Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622
分子名称:	6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine, Macrophage colony-stimulating factor 1 receptor
著者	Zhang, Y.
登録日	2018-11-14
公開日	2019-09-18
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun, 10, 2019

4DRF

Crystal Structure of Bacterial Pnkp-C/Hen1-N Heterodimer
分子名称:	GLYCEROL, Metallophosphoesterase, Methyltransferase type 12
著者	Huang, R.H, Wang, P.
登録日	2012-02-17
公開日	2012-08-01
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.6 Å)
主引用文献	Molecular basis of bacterial protein Hen1 activating the ligase activity of bacterial protein Pnkp for RNA repair. Proc.Natl.Acad.Sci.USA, 109, 2012

4ZBN

Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor
分子名称:	4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-nerve growth factor, DNA (28-MER)
著者	Davies, D.R, Edwards, T.E.
登録日	2015-04-15
公開日	2015-06-10
最終更新日	2015-07-15
実験手法	X-RAY DIFFRACTION (2.447 Å)
主引用文献	Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor. Structure, 23, 2015

5F9P

Crystal structure study of anthrone oxidase-like protein
分子名称:	Anthrone oxidase-like protein, GLYCEROL
著者	Gao, X, Wu, D, Fan, K, Liu, Z.-J.
登録日	2015-12-10
公開日	2016-12-14
最終更新日	2018-07-18
実験手法	X-RAY DIFFRACTION (2.078 Å)
主引用文献	Structure and Function of a C-C Bond Cleaving Oxygenase in Atypical Angucycline Biosynthesis ACS Chem. Biol., 12, 2017

2EXX

Crystal structure of HSCARG from Homo sapiens in complex with NADP
分子名称:	GLYCEROL, HSCARG protein, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者	Dai, X, Chen, Q, Yao, D, Liang, Y, Dong, Y, Gu, X, Zheng, X, Luo, M.
登録日	2005-11-09
公開日	2006-11-21
最終更新日	2017-10-18
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. Proc.Natl.Acad.Sci.USA, 104, 2007

2GKD

Structural insight into self-sacrifice mechanism of enediyne resistance
分子名称:	5'-D(CPTPAPTPCPAPTPAPTPGPC)-3', 5'-D(GPCPAPTPAPTPGPAPTPAPG)-3', CalC
著者	Singh, S, Thorson, J.S.
登録日	2006-04-01
公開日	2006-08-22
最終更新日	2024-05-29
実験手法	SOLUTION NMR
主引用文献	Structural insight into the self-sacrifice mechanism of enediyne resistance. Acs Chem.Biol., 1, 2006

6JCB

Crystal structure of aminotransferase CrmG from Actinoalloteichus sp. WH1-2216-6 in C2 space group
分子名称:	CrmG
著者	Xu, J, Liu, J.
登録日	2019-01-28
公開日	2020-02-05
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (2.85 Å)
主引用文献	Structural studies reveal flexible roof of active site responsible for omega-transaminase CrmG overcoming by-product inhibition. Commun Biol, 3, 2020

6JLC

Structure determination of CAMP factor of Mobiluncus curtisii and insight into structural dynamics
分子名称:	ACETATE ION, CAMP factor
著者	Jin, T.C, Zeng, W.H.
登録日	2019-03-04
公開日	2019-12-04
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.847 Å)
主引用文献	Structure determination of CAMP factor of Mobiluncus curtisii and insights into structural dynamics. Int.J.Biol.Macromol., 150, 2020

7WVO

SARS-CoV-2 Omicron S-open-2
分子名称:	Spike glycoprotein
著者	Li, J.W, Cong, Y.
登録日	2022-02-10
公開日	2022-03-02
最終更新日	2022-05-04
実験手法	ELECTRON MICROSCOPY (3.41 Å)
主引用文献	Molecular basis of receptor binding and antibody neutralization of Omicron. Nature, 604, 2022

8IUO

respiratory syncytial virus nucleocapsid-like assembly
分子名称:	Nucleoprotein, RNA (35-MER)
著者	Wang, Y, Luo, Y, Ling, X, Luo, B, Jia, G, Dong, H, Su, Z.
登録日	2023-03-24
公開日	2023-09-06
実験手法	ELECTRON MICROSCOPY (3.96 Å)
主引用文献	Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus. Signal Transduct Target Ther, 8, 2023

7WVN

SARS-CoV-2 Omicron S-open
分子名称:	Spike glycoprotein
著者	Li, J.W, Cong, Y.
登録日	2022-02-10
公開日	2022-03-02
最終更新日	2022-05-04
実験手法	ELECTRON MICROSCOPY (3.4 Å)
主引用文献	Molecular basis of receptor binding and antibody neutralization of Omicron. Nature, 604, 2022

2L6H

Fat domain of focal adhesion kinase tethered to LD4 motif of paxillin via GGS linker
分子名称:	Focal adhesion kinase 1, linker, Paxillin
著者	Bertolucci, C.M, Guibao, C, Zhang, C, Zheng, J.
登録日	2010-11-19
公開日	2012-05-30
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	Fat Domain of Focal Adhesion Kinase Tethered to Ld4 Motif of Paxillin via GGS Linker To be Published

8JPX

Cryo-EM structure of PfAgo-guide DNA-target DNA complex
分子名称:	Excess DNA, Guide DNA, MAGNESIUM ION, ...
著者	Zhuang, L.
登録日	2023-06-13
公開日	2024-01-31
最終更新日	2024-05-01
実験手法	ELECTRON MICROSCOPY (2.9 Å)
主引用文献	Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute. Mol.Cell, 84, 2024

2L6F

NMR Solution structure of FAT domain of FAK complexed with LD2 and LD4 motifs of PAXILLIN
分子名称:	Focal adhesion kinase 1, linker1, Paxillin, ...
著者	Bertolucci, C.M, Guibao, C, Zhang, C, Zheng, J.
登録日	2010-11-19
公開日	2012-05-30
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	NMR Solution Structure of Fat Domain of Fak Complexed with Ld2 and Ld4 Motifs of Paxillin To be Published

5ZTC

Apo structure of TetR family transcription regulator Lmo2088 of Listeria monocytogenes EGDe
分子名称:	Lmo2088 protein, PENTAETHYLENE GLYCOL
著者	Samad, A, Jin, T.
登録日	2018-05-02
公開日	2019-06-12
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	X-ray crystal structure of putative transcription regulator lmo2088 from Listeria monocytogenes. Biochem.Biophys.Res.Commun., 520, 2019

7Y9V

Structure of the auxin exporter PIN1 in Arabidopsis thaliana in the IAA-bound state
分子名称:	1H-INDOL-3-YLACETIC ACID, Auxin efflux carrier component 1, nanobody
著者	Sun, L, Liu, X, Yang, Z, Xia, J.
登録日	2022-06-26
公開日	2022-09-07
最終更新日	2022-09-28
実験手法	ELECTRON MICROSCOPY (3.2 Å)
主引用文献	Structural insights into auxin recognition and efflux by Arabidopsis PIN1. Nature, 609, 2022

7Y4H

AcvX from Actinomadura viridis that exhibits deglycosylation activity on lobophorins
分子名称:	AcvX
著者	Tan, B, Zhang, L.P, Zhang, C.S.
登録日	2022-06-14
公開日	2023-05-24
最終更新日	2024-04-03
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	A Widespread Glycosidase Confers Lobophorin Resistance and Host-Dependent Structural Diversity. Angew.Chem.Int.Ed.Engl., 62, 2023

7DGB

The co-crystal structure of SARS-CoV-2 main protease with (S)-2-cinnamamido-4-methyl-N-((S)-1-oxo-3-((S)-2-oxopyrrolidin-3-yl)propan-2-yl)pentanamide
分子名称:	(2~{S})-4-methyl-~{N}-[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide, 3C-like proteinase
著者	Shang, L.Q, Wang, H.
登録日	2020-11-11
公開日	2021-11-24
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.678 Å)
主引用文献	The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022

7DGH

The co-crystal structure of SARS-CoV-2 main protease with peptidomimetic inhibitor N-((S)-3-methyl-1-(((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-((S)-2-oxopiperidin-3-yl)propan-2-yl)amino)pentan-2-yl)amino)-1-oxobutan-2-yl)-2-naphthamide
分子名称:	3C-like proteinase, ~{N}-[(2~{S})-3-methyl-1-[[(2~{S})-4-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanylidene-3-[(3~{S})-2-oxidanylidenepiperidin-3-yl]propan-2-yl]amino]pentan-2-yl]amino]-1-oxidanylidene-butan-2-yl]naphthalene-2-carboxamide
著者	Shang, L.Q, Wang, H.
登録日	2020-11-11
公開日	2021-11-24
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.968 Å)
主引用文献	The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate. Eur.J.Med.Chem., 238, 2022

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