5Y37

Crystal structure of GBS GAPDH

Summary for 5Y37

Entry DOI	10.2210/pdb5y37/pdb
Descriptor	Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION, ... (4 entities in total)
Functional Keywords	group b streptococcus, transferase
Biological source	Streptococcus agalactiae serotype III (strain NEM316)
Total number of polymer chains	4
Total formula weight	149192.26
Authors	Jin, T.,Zhou, K. (deposition date: 2017-07-28, release date: 2018-04-18, Last modification date: 2023-11-22)
Primary citation	Zhou, K.,Fan, X.,Li, Y.,Zhang, C.,Jin, T. High-resolution crystal structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase. Acta Crystallogr.,Sect.F, 74:236-244, 2018 Cited by PubMed Abstract: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a multifunctional enzyme that plays critical roles in bacterial pathogenesis in some pathogenic bacteria. In this study, the crystal structure of group B streptococcus GAPDH was determined at 1.36 Å resolution. The structure contained an asymmetric mixed holo tetramer, with two NAD ligands bound to two protomers. Further structural analysis identified interesting phosphate ion-binding sites, which shed light on its catalytic mechanism. PubMed: 29633972 DOI: 10.1107/S2053230X18003801 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.36 Å)

Structure validation