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8SER
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BU of 8ser by Molmil
Cryo-EM Structure of RyR1 + Adenosine
分子名称: ADENOSINE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SES
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BU of 8ses by Molmil
Cryo-EM Structure of RyR1 + Adenine
分子名称: ADENINE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.98 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEP
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BU of 8sep by Molmil
Cryo-EM Structure of RyR1 + ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEO
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BU of 8seo by Molmil
Cryo-EM Structure of RyR1 + ATP-gamma-S
分子名称: Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Ryanodine receptor 1, ...
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.92 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEZ
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BU of 8sez by Molmil
Cryo-EM Structure of RyR1 + Adenine (Local Refinement of TMD)
分子名称: ADENINE, Ryanodine receptor 1, ZINC ION
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SET
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BU of 8set by Molmil
Cryo-EM Structure of RyR1 + cAMP
分子名称: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.42 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEQ
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BU of 8seq by Molmil
Cryo-EM Structure of RyR1 + AMP
分子名称: ADENOSINE MONOPHOSPHATE, Glutathione S-transferase class-mu 26 kDa isozyme,Peptidyl-prolyl cis-trans isomerase FKBP1B, Ryanodine receptor 1, ...
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEY
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BU of 8sey by Molmil
Cryo-EM Structure of RyR1 + Adenosine (Local Refinement of TMD)
分子名称: ADENOSINE, Ryanodine receptor 1, ZINC ION
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEV
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BU of 8sev by Molmil
Cryo-EM Structure of RyR1 + ATP-gamma-S (Local Refinement of TMD)
分子名称: PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Ryanodine receptor 1, ZINC ION
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3.17 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
8SEU
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BU of 8seu by Molmil
Cryo-EM Structure of RyR1 (Local Refinement of TMD)
分子名称: Ryanodine receptor 1, ZINC ION
著者Cholak, S, Saville, J.W, Zhu, X, Berezuk, A.M, Tuttle, K.S, Haji-Ghassemi, O, Van Petegem, F, Subramaniam, S.
登録日2023-04-10
公開日2023-05-24
最終更新日2023-07-19
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives.
Structure, 31, 2023
6MUD
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BU of 6mud by Molmil
Voltage-gated sodium channel NaV1.5 C-terminal domain in complex with Ca2+/Calmodulin
分子名称: CALCIUM ION, Calmodulin-1, Sodium channel protein type 5 subunit alpha
著者Gardill, B.R, Tung, C.C, Van Petegem, F.
登録日2018-10-23
公開日2019-05-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Crystal structures of Ca2+-calmodulin bound to NaVC-terminal regions suggest role for EF-hand domain in binding and inactivation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6MUE
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BU of 6mue by Molmil
Voltage-gated sodium channel NaV1.4 IQ domain in complex with Ca2+/Calmodulin
分子名称: CALCIUM ION, Calmodulin-1, Sodium channel protein type 4 subunit alpha
著者Gardill, B.R, Van Petegem, F.
登録日2018-10-23
公開日2019-05-08
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structures of Ca2+-calmodulin bound to NaVC-terminal regions suggest role for EF-hand domain in binding and inactivation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6PAL
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BU of 6pal by Molmil
Bacteroides uniformis endo-laminarinase BuGH158 from the beta(1,3)-glucan utilization locus
分子名称: ACETATE ION, SULFATE ION, Uncharacterized protein
著者Tamura, K, Brumer, H, van Petegem, F.
登録日2019-06-11
公開日2020-04-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.818 Å)
主引用文献Synergy between Cell Surface Glycosidases and Glycan-Binding Proteins Dictates the Utilization of Specific Beta(1,3)-Glucans by Human GutBacteroides.
Mbio, 11, 2020
6PYA
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BU of 6pya by Molmil
Sex Hormone-binding globulin mutant E176K in complex with IPI
分子名称: 3-[(1H-imidazol-1-yl)methyl]-2-phenyl-1H-indole, CALCIUM ION, Sex hormone-binding globulin
著者Round, P.W, Das, S, Van Petegem, F.
登録日2019-07-29
公開日2019-12-25
最終更新日2020-02-12
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
6PYF
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BU of 6pyf by Molmil
Sex Hormone-binding globulin mutant E176K in complex with Estradiol
分子名称: CALCIUM ION, ESTRADIOL, Sex hormone-binding globulin
著者Round, P.W, Wu, T.S, Das, S, Van Petegem, F.
登録日2019-07-29
公開日2019-12-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
6PYB
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BU of 6pyb by Molmil
Sex Hormone-binding globulin mutant E176K in complex with DVT
分子名称: 4,4'-[(3R,4R)-oxolane-3,4-diylbis(methylene)]bis(2-methoxyphenol), CALCIUM ION, Sex hormone-binding globulin
著者Round, P.W, Das, S, Van Petegem, F.
登録日2019-07-29
公開日2019-12-25
最終更新日2020-02-12
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity.
J.Biol.Chem., 295, 2020
6VSV
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BU of 6vsv by Molmil
Crystal structure of a disease mutant of the Voltage-gated Sodium Channel Beta 4 subunit extracellular domain
分子名称: Sodium channel subunit beta-4
著者Das, S, Van Petegem, F.
登録日2020-02-12
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Biophysical Investigation of Sodium Channel Interaction with beta-Subunit Variants Associated with Arrhythmias.
Bioelectricity, 2, 2020
6VRR
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BU of 6vrr by Molmil
Crystal structure of a disease mutant of the Voltage-gated Sodium Channel Beta 2 subunit extracellular domain
分子名称: GLYCEROL, Sodium channel subunit beta-2
著者Das, S, Van Petegem, F.
登録日2020-02-09
公開日2020-08-26
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Biophysical Investigation of Sodium Channel Interaction with beta-Subunit Variants Associated with Arrhythmias.
Bioelectricity, 2, 2020
3ILA
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BU of 3ila by Molmil
Crystal structure of rabbit ryanodine receptor 1 N-terminal domain (9-205)
分子名称: Ryanodine receptor 1
著者Lobo, P.A, Van Petegem, F.
登録日2009-08-06
公開日2009-11-17
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures of the N-terminal domains of cardiac and skeletal muscle ryanodine receptors: insights into disease mutations.
Structure, 17, 2009
6U3D
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BU of 6u3d by Molmil
1.75 Angstrom crystal structure of the N53I Ca-CaM:CaV1.2 IQ domain complex
分子名称: CALCIUM ION, Calmodulin-1, Voltage-dependent L-type calcium channel subunit alpha-1C
著者Wang, K, Van Petegem, F.
登録日2019-08-21
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca2+binding and cause misfolding.
J. Physiol. (Lond.), 598, 2020
6ULB
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BU of 6ulb by Molmil
Sex Hormone-binding globulin mutant E176K in complex with Danazol
分子名称: CALCIUM ION, Danazol, Sex hormone-binding globulin
著者Round, P.W, Das, S, Van Petegem, F.
登録日2019-10-07
公開日2020-10-21
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and biochemical analyses of danazol interactions with sex hormone-binding globulin and effects on androgen action
To Be Published
4P9I
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BU of 4p9i by Molmil
Crystal Structure of mouse Ryanodine Receptor 2 SPRY2 Domain (1080-1253)
分子名称: Ryanodine receptor 2
著者Lau, K, Van Petegem, F.
登録日2014-04-04
公開日2014-11-05
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.3401 Å)
主引用文献Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.
Nat Commun, 5, 2014
4P9J
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BU of 4p9j by Molmil
Crystal Structure of rabbit Ryanodine Receptor 1 SPRY2 Domain (1070-1246)
分子名称: Ryanodine receptor 1
著者Lau, K, Van Petegem, F.
登録日2014-04-04
公開日2014-11-05
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.
Nat Commun, 5, 2014
4P9L
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BU of 4p9l by Molmil
Crystal Structure of mouse Ryanodine Receptor 2 SPRY2 Domain (1080-1253) disease mutant A1107M
分子名称: Ryanodine receptor 2
著者Lau, K, Van Petegem, F.
登録日2014-04-04
公開日2014-11-05
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4361 Å)
主引用文献Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.
Nat Commun, 5, 2014
5KHI
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BU of 5khi by Molmil
HCN2 CNBD in complex with purine riboside-3', 5'-cyclic monophosphate (cPuMP)
分子名称: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2, Purine riboside-3',5'-cyclic monophosphate
著者Ng, L.C.T, Putrenko, I, Baronas, V, Van Petegem, F, Accili, E.A.
登録日2016-06-14
公開日2016-09-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Cyclic Purine and Pyrimidine Nucleotides Bind to the HCN2 Ion Channel and Variably Promote C-Terminal Domain Interactions and Opening.
Structure, 24, 2016

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