8HF3
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![BU of 8hf3 by Molmil](/molmil-images/mine/8hf3) | Cryo-EM structure of human ZDHHC9/GCP16 complex | 分子名称: | 1,2-DILAUROYL-SN-GLYCERO-3-PHOSPHATE, Golgin subfamily A member 7, PALMITIC ACID, ... | 著者 | Wu, J, Hu, Q, Zhang, Y, Liu, S, Yang, A. | 登録日 | 2022-11-09 | 公開日 | 2023-11-22 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation. Nat.Struct.Mol.Biol., 31, 2024
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5GXO
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![BU of 5gxo by Molmil](/molmil-images/mine/5gxo) | Discovery of a compound that activates SIRT3 to deacetylate Manganese Superoxide Dismutase | 分子名称: | MANGANESE (II) ION, Superoxide dismutase [Mn], mitochondrial | 著者 | Lu, J, Li, J, Wu, M, Wang, J, Xia, Q. | 登録日 | 2016-09-19 | 公開日 | 2017-08-09 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase. Free Radic. Biol. Med., 112, 2017
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5L30
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![BU of 5l30 by Molmil](/molmil-images/mine/5l30) | Factor VIIa in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1H-tetrazol-5-yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione | 分子名称: | (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1H-tetrazol-5-yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione, CALCIUM ION, Coagulation factor VII (Heavy Chain), ... | 著者 | Wei, A. | 登録日 | 2016-08-02 | 公開日 | 2016-09-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
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5L2Z
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![BU of 5l2z by Molmil](/molmil-images/mine/5l2z) | Factor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid | 分子名称: | 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclohexane-1-carboxylic acid, CALCIUM ION, Coagulation factor VII (Heavy Chain), ... | 著者 | Wei, A. | 登録日 | 2016-08-02 | 公開日 | 2016-09-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
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5L2Y
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![BU of 5l2y by Molmil](/molmil-images/mine/5l2y) | Factor VIIa in complex with the inhibitor 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,20-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6,8,10(21),16,19-hexaen-7-yl] cyclobutane-1-carboxylic acid | 分子名称: | 1-[(2R,15R)-2-[(1-amino-4-fluoroisoquinolin-6-yl)amino]-4,15,17-trimethyl-3,12-dioxo-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaen-7-yl]cyclobutane-1-carboxylic acid, CALCIUM ION, Coagulation factor VII (Heavy Chain), ... | 著者 | Wei, A. | 登録日 | 2016-08-02 | 公開日 | 2016-09-28 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. Bioorg.Med.Chem.Lett., 26, 2016
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5MEZ
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![BU of 5mez by Molmil](/molmil-images/mine/5mez) | Crystal structure of Smad4-MH1 bound to the GGCT site. | 分子名称: | CHLORIDE ION, DNA (5'-D(P*GP*CP*AP*GP*GP*CP*TP*AP*GP*CP*CP*TP*GP*CP*A)-3'), MH1 domain of human Smad4, ... | 著者 | Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J. | 登録日 | 2016-11-16 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8, 2017
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5MEY
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![BU of 5mey by Molmil](/molmil-images/mine/5mey) | Crystal structure of Smad4-MH1 bound to the GGCGC site. | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | 著者 | Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J. | 登録日 | 2016-11-16 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8, 2017
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5MF0
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![BU of 5mf0 by Molmil](/molmil-images/mine/5mf0) | Crystal structure of Smad4-MH1 bound to the GGCCG site. | 分子名称: | CHLORIDE ION, DNA (5'-D(P*AP*CP*GP*GP*GP*CP*CP*GP*CP*GP*GP*CP*CP*CP*GP*T)-3'), MH1 domain of human Smad4, ... | 著者 | Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J. | 登録日 | 2016-11-16 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (3.03 Å) | 主引用文献 | Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8, 2017
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5NM9
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![BU of 5nm9 by Molmil](/molmil-images/mine/5nm9) | Crystal structure of the placozoa Trichoplax adhaerens Smad4-MH1 bound to the GGCGC site. | 分子名称: | DNA (5'-D(P*AP*TP*GP*CP*GP*GP*GP*CP*GP*CP*GP*CP*CP*CP*GP*CP*AP*T)-3'), Mothers against decapentaplegic homolog, ZINC ION | 著者 | Kaczmarska, Z, Freier, R, Marquez, J.A, Macias, M.J. | 登録日 | 2017-04-05 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors. Nat Commun, 8, 2017
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3RER
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![BU of 3rer by Molmil](/molmil-images/mine/3rer) | Crystal structure of E. coli Hfq in complex with AU6A RNA and ADP | 分子名称: | 5'-R(*AP*UP*UP*UP*UP*UP*UP*A)-3', ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Wang, W.W, Wu, J.H, Shi, Y.Y. | 登録日 | 2011-04-05 | 公開日 | 2011-10-19 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Cooperation of Escherichia coli Hfq hexamers in DsrA binding. Genes Dev., 25, 2011
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3RES
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8DL5
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![BU of 8dl5 by Molmil](/molmil-images/mine/8dl5) | |
4LWP
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![BU of 4lwp by Molmil](/molmil-images/mine/4lwp) | Crystal structure of PRMT6-SAH | 分子名称: | Arginine N-methyltransferase, putative, IODIDE ION, ... | 著者 | Zhu, Y, Wang, C, Shi, Y, Teng, M. | 登録日 | 2013-07-28 | 公開日 | 2014-02-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.353 Å) | 主引用文献 | Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei Plos One, 9, 2014
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8ERB
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![BU of 8erb by Molmil](/molmil-images/mine/8erb) | Crystal structure of Fub7 in complex with vinylglycine ketimine | 分子名称: | (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, Sulfhydrylase FUB7 | 著者 | Hai, Y. | 登録日 | 2022-10-11 | 公開日 | 2023-10-18 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Molecular and Structural Basis for C gamma-C Bond Formation by PLP-Dependent Enzyme Fub7. Angew.Chem.Int.Ed.Engl., 63, 2024
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8EQW
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![BU of 8eqw by Molmil](/molmil-images/mine/8eqw) | Crystal structure of Fub7 | 分子名称: | Sulfhydrylase FUB7 | 著者 | Hai, Y. | 登録日 | 2022-10-10 | 公開日 | 2023-10-11 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Molecular and Structural Basis for C gamma-C Bond Formation by PLP-Dependent Enzyme Fub7. Angew.Chem.Int.Ed.Engl., 63, 2024
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8ERJ
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![BU of 8erj by Molmil](/molmil-images/mine/8erj) | Crystal structure of Fub7 in complex with E-2-aminocrotonate | 分子名称: | (2E)-2-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}but-2-enoic acid, (2S)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]but-3-enoic acid, Sulfhydrylase FUB7 | 著者 | Hai, Y. | 登録日 | 2022-10-12 | 公開日 | 2023-10-25 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Molecular and Structural Basis for C gamma-C Bond Formation by PLP-Dependent Enzyme Fub7. Angew.Chem.Int.Ed.Engl., 63, 2024
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4LWO
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![BU of 4lwo by Molmil](/molmil-images/mine/4lwo) | Crystal structure of PRMT6 | 分子名称: | Arginine N-methyltransferase, putative | 著者 | Zhu, Y, Wang, C, Shi, Y, Teng, M. | 登録日 | 2013-07-28 | 公開日 | 2014-02-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.203 Å) | 主引用文献 | Crystal Structure of Arginine Methyltransferase 6 from Trypanosoma brucei Plos One, 9, 2014
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3WOH
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![BU of 3woh by Molmil](/molmil-images/mine/3woh) | |
7RHA
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![BU of 7rha by Molmil](/molmil-images/mine/7rha) | A new fluorescent protein darkmRuby at pH 5.0 | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | 著者 | Huang, M, Ng, H.L, Zhang, S, Deng, M, Chu, J. | 登録日 | 2021-07-16 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure of a new fluorescent protein darkmRuby at pH 5.0 To Be Published
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7RHB
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7RHD
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![BU of 7rhd by Molmil](/molmil-images/mine/7rhd) | darkmRuby M94T/F96Y mutant at pH 7.5 | 分子名称: | 1,2-ETHANEDIOL, darkmRuby M94T/F96Y mutant | 著者 | Huang, M, Ng, H.L, Zhang, S, Deng, M, Chu, J. | 登録日 | 2021-07-16 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Long-range Interaction Affects Brightness and pH Stability of a Dark Fluorescent Protein To Be Published
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7RHC
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![BU of 7rhc by Molmil](/molmil-images/mine/7rhc) | A new fluorescent protein darkmRuby at pH 9.0 | 分子名称: | 1,2-ETHANEDIOL, darkmRuby | 著者 | Huang, M, Ng, H.L, Zhang, S, Deng, M, Chu, J. | 登録日 | 2021-07-16 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Long-range Interaction Affects Brightness and pH Stability of a Dark Fluorescent Protein To Be Published
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8I7L
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![BU of 8i7l by Molmil](/molmil-images/mine/8i7l) | Crystal structure of indoleamine 2,3-dioxygenagse 1 (IDO1) complexed with a novel inhibitor | 分子名称: | 1-[3-[(4-chloranyl-2-fluoranyl-phenyl)carbamoylamino]-4-[cyclohexyl(2-methylpropyl)amino]phenyl]pyrrole-2-carboxylic acid, Indoleamine 2,3-dioxygenase 1, THIOSULFATE | 著者 | Li, K, Liu, W, Dong, X. | 登録日 | 2023-02-01 | 公開日 | 2023-02-15 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Apo-Form Selective Inhibition of IDO for Tumor Immunotherapy. J Immunol., 209, 2022
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2KH6
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![BU of 2kh6 by Molmil](/molmil-images/mine/2kh6) | Solution Structure of cis-5R,6S-thymine glycol opposite complementary adenine in duplex DNA | 分子名称: | 5'-D(*AP*CP*AP*AP*AP*CP*AP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*(CTG)P*GP*TP*TP*TP*GP*T)-3' | 著者 | Brown, K.L. | 登録日 | 2009-03-24 | 公開日 | 2010-03-02 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site Nucleic Acids Res., 38, 2010
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2KH5
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![BU of 2kh5 by Molmil](/molmil-images/mine/2kh5) | Solution Structure of cis-5R,6S-thymine glycol opposite complementary adenine in duplex DNA | 分子名称: | 5'-D(*AP*CP*AP*AP*AP*CP*AP*CP*GP*CP*AP*C)-3', 5'-D(*GP*TP*GP*CP*GP*(CTG)P*GP*TP*TP*TP*GP*T)-3' | 著者 | Brown, K.L. | 登録日 | 2009-03-24 | 公開日 | 2010-03-02 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site Nucleic Acids Res., 38, 2010
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