5L30

Factor VIIa in complex with the inhibitor (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1H-tetrazol-5-yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione

Summary for 5L30

• Entry DOI: 10.2210/pdb5l30/pdb
• Descriptor: Coagulation factor VII (Heavy Chain), Coagulation factor VII (Light Chain), (2R,15R)-2-[(1-aminoisoquinolin-6-yl)amino]-4,15,17-trimethyl-7-[1-(1H-tetrazol-5-yl)cyclopropyl]-13-oxa-4,11-diazatricyclo[14.2.2.1~6,10~]henicosa-1(18),6(21),7,9,16,19-hexaene-3,12-dione, ... (7 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 35716.68

Authors

Wei, A. (deposition date: 2016-08-02, release date: 2016-09-28, Last modification date: 2023-10-04)

• Primary citation: Ladziata, V.U.,Glunz, P.W.,Zou, Y.,Zhang, X.,Jiang, W.,Jacutin-Porte, S.,Cheney, D.L.,Wei, A.,Luettgen, J.M.,Harper, T.M.,Wong, P.C.,Seiffert, D.,Wexler, R.R.,Priestley, E.S.; Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors.; Bioorg.Med.Chem.Lett., 26:5051-5057, 2016; PubMed: 27612545; DOI: 10.1016/j.bmcl.2016.08.088

Experimental method

X-RAY DIFFRACTION (1.73 Å)