2KH6

Solution Structure of cis-5R,6S-thymine glycol opposite complementary adenine in duplex DNA

Summary for 2KH6

• Entry DOI: 10.2210/pdb2kh6/pdb
• Related: 2KH5
• NMR Information: BMRB: 16225
• Descriptor: 5'-D(*GP*TP*GP*CP*GP*(CTG)P*GP*TP*TP*TP*GP*T)-3', 5'-D(*AP*CP*AP*AP*AP*CP*AP*CP*GP*CP*AP*C)-3' (2 entities in total)
• Functional Keywords: thymine glycol, dna
• Total number of polymer chains: 2
• Total formula weight: 7358.82

Authors

Brown, K.L. (deposition date: 2009-03-24, release date: 2010-03-02, Last modification date: 2020-02-26)

• Primary citation: Brown, K.L.,Roginskaya, M.,Zou, Y.,Altamirano, A.,Basu, A.K.,Stone, M.P.; Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site; Nucleic Acids Res., 38:428-440, 2010; PubMed: 19892827; DOI: 10.1093/nar/gkp844

Experimental method

SOLUTION NMR