7PRB
| Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent inhibitor GR109 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-6-O-sulfo-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Glyco_hydro_44 domain-containing protein | 著者 | Wu, L, Armstrong, Z, Davies, G.J. | 登録日 | 2021-09-21 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PR6
| Crystal structure of E. coli beta-glucuronidase in complex with covalent inhibitor ME727 | 分子名称: | (2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Beta-glucuronidase | 著者 | Wu, L, Armstrong, Z, Davies, G.J. | 登録日 | 2021-09-20 | 公開日 | 2022-08-03 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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7PR9
| Crystal structure of Burkholderia pseudomallei heparanase in complex with covalent inhibitor VL166 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-(2R,3S,5R,6R)-2,3,4,5,6-pentakis(oxidanyl)cyclohexane-1-carboxylic acid, Glyco_hydro_44 domain-containing protein | 著者 | Wu, L, Armstrong, Z, Davies, G.J. | 登録日 | 2021-09-21 | 公開日 | 2022-08-03 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | 主引用文献 | Mechanism-based heparanase inhibitors reduce cancer metastasis in vivo. Proc.Natl.Acad.Sci.USA, 119, 2022
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5I24
| Crystal Structure of Agd31B, alpha-transglucosylase in Glycoside Hydrolase Family 31, in complex with Cyclophellitol Aziridine probe CF021 | 分子名称: | (1R,2S,3S,4R,5S,6R)-5-amino-6-(hydroxymethyl)cyclohexane-1,2,3,4-tetrol, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | 著者 | Wu, L, Davies, G.J. | 登録日 | 2016-02-08 | 公開日 | 2016-05-04 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Detection of Active Mammalian GH31 alpha-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes. Acs Cent.Sci., 2, 2016
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5L77
| A glycoside hydrolase mutant with an unreacted activity based probe bound | 分子名称: | (1~{R},2~{S},3~{R},4~{S},5~{S},6~{R})-7-[8-[(azanylidene-{4}-azanylidene)amino]octyl]-3,4,5-tris(oxidanyl)-7-azabicyclo[4.1.0]heptane-2-carboxylic acid, CHLORIDE ION, GLYCEROL, ... | 著者 | Jin, Y, Wu, L, Jiang, J.B, Overkleeft, H.S, Davies, G.J. | 登録日 | 2016-06-02 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | Activity-based probes for functional interrogation of retaining beta-glucuronidases. Nat. Chem. Biol., 13, 2017
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2L7T
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2LSR
| Solution structure of harmonin N terminal domain in complex with a exon68 encoded peptide of cadherin23 | 分子名称: | Harmonin, peptide from Cadherin-23 | 著者 | Pan, L, Wu, L, Zhang, C, Zhang, M. | 登録日 | 2012-05-04 | 公開日 | 2012-08-15 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Large protein assemblies formed by multivalent interactions between cadherin23 and harmonin suggest a stable anchorage structure at the tip link of stereocilia. J.Biol.Chem., 287, 2012
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4FTW
| Crystal structure of a carboxyl esterase N110C/L145H at 2.3 angstrom resolution | 分子名称: | 3-CYCLOHEXYLPROPYL 4-O-ALPHA-D-GLUCOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE, CHLORIDE ION, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID), ... | 著者 | Wu, L, Ma, J, Zhou, J, Yu, H. | 登録日 | 2012-06-28 | 公開日 | 2012-10-03 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution. Appl.Microbiol.Biotechnol., 97, 2013
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5G0Q
| beta-glucuronidase with an activity-based probe (N-alkyl cyclophellitol aziridine) bound | 分子名称: | (1R,2S,3R,4S,5S,6R)-7-(8-AZIDOOCTYL)-3,4,5-TRIHYDROXY-, BETA-GLUCURONIDASE, GLYCEROL | 著者 | Jin, Y, Wu, L, Jiang, J.B, Overkleeft, H.S, Davies, G.J. | 登録日 | 2016-03-22 | 公開日 | 2017-04-12 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Activity-based probes for functional interrogation of retaining beta-glucuronidases. Nat. Chem. Biol., 13, 2017
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6KTW
| structure of EanB with hercynine | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | 著者 | Wu, L, Liu, P.H, Zhou, J.H. | 登録日 | 2019-08-29 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.931 Å) | 主引用文献 | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Acs Catalysis, 10, 2020
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6KU2
| The structure of EanB/Y353A complex with ergothioneine covalent linked with persulfide Cys412 | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... | 著者 | Wu, L, Liu, P.H, Zhou, J.H. | 登録日 | 2019-08-30 | 公開日 | 2020-08-26 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Acs Catalysis, 10, 2020
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6KTZ
| The complex structure of EanB/C412S with hercynine | 分子名称: | 1,2-ETHANEDIOL, BROMIDE ION, CHLORIDE ION, ... | 著者 | Wu, L, Liu, P.H, Zhou, J.H. | 登録日 | 2019-08-29 | 公開日 | 2020-08-26 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Acs Catalysis, 10, 2020
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6KTV
| The structure of EanB complex with hercynine and persulfided Cys412 | 分子名称: | 1,2-ETHANEDIOL, 1,3-PROPANDIOL, CHLORIDE ION, ... | 著者 | Wu, L, Liu, P.H, Zhou, J.H. | 登録日 | 2019-08-29 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Acs Catalysis, 10, 2020
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6KTX
| The wildtype structure of EanB | 分子名称: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, CHLORIDE ION, ... | 著者 | Wu, L, Liu, P.H, Zhou, J.H. | 登録日 | 2019-08-29 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.189 Å) | 主引用文献 | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Acs Catalysis, 10, 2020
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6KU1
| The structure of EanB/Y353A complex with ergothioneine | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Wu, L, Liu, P.H, Zhou, J.H. | 登録日 | 2019-08-30 | 公開日 | 2020-08-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis Acs Catalysis, 10, 2020
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6HZY
| Crystal structure of a bacterial fucosidase with inhibitor FucPUG | 分子名称: | 1,2-ETHANEDIOL, Alpha-L-fucosidase, SULFATE ION, ... | 著者 | Wu, L, Davies, G.J, Stubbs, K.A, Coyle, T, Debowski, A.W. | 登録日 | 2018-10-24 | 公開日 | 2019-02-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Synthetic and Crystallographic Insight into Exploiting sp2Hybridization in the Development of alpha-l-Fucosidase Inhibitors. Chembiochem, 20, 2019
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7ETK
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7ETL
| The crystal structure of FtmOx1-Y68F | 分子名称: | 1,2-ETHANEDIOL, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | 著者 | Zhou, J.H, Wu, L. | 登録日 | 2021-05-13 | 公開日 | 2021-12-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.992128 Å) | 主引用文献 | Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1. Angew.Chem.Int.Ed.Engl., 61, 2022
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7V3E
| The complex structure of soBcmB and its intermediate product 1a | 分子名称: | (3S,6Z)-3-[(2S)-butan-2-yl]-6-[(2R)-2-methyl-2,3-bis(oxidanyl)propylidene]piperazine-2,5-dione, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | 著者 | Wu, L, Zhou, J.H. | 登録日 | 2021-08-10 | 公開日 | 2023-02-15 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis Nat Catal, 6, 2023
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7V34
| The complex structure of soBcmB and its product 1d | 分子名称: | (3S,4S,5S,8S)-8-[(2S)-butan-2-yl]-3-methyl-3,4-bis(oxidanyl)-1-oxa-7,10-diazaspiro[4.5]decane-6,9-dione, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | 著者 | Wu, L, Zhou, J.H. | 登録日 | 2021-08-10 | 公開日 | 2023-02-15 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (2.000169 Å) | 主引用文献 | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis Nat Catal, 6, 2023
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7V36
| The complex structure of soBcmB and its intermediate product 2a | 分子名称: | (3Z,6S)-3-[(2R)-2-methyl-2,3-bis(oxidanyl)propylidene]-6-[(2S)-4-oxidanylbutan-2-yl]piperazine-2,5-dione, 2-OXOGLUTARIC ACID, CHLORIDE ION, ... | 著者 | Wu, L, Zhou, J.H. | 登録日 | 2021-08-10 | 公開日 | 2023-02-15 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.96009171 Å) | 主引用文献 | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis Nat Catal, 6, 2023
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7V3N
| The complex structure of soBcmB-D307A and its natural precursor 2 | 分子名称: | (3S,6S)-3-((R)-2,3-dihydroxy-2-methylpropyl)-6-((S)-4-hydroxybutan-2-yl)piperazine-2,5-dione, 2-OXOGLUTARIC ACID, FE (II) ION, ... | 著者 | Wu, L, Zhou, J.H. | 登録日 | 2021-08-10 | 公開日 | 2023-02-15 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.850011 Å) | 主引用文献 | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis Nat Catal, 6, 2023
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7V3O
| The structure of Se-SoBcmB with Fe(II)and AKG | 分子名称: | 2-OXOGLUTARIC ACID, CHLORIDE ION, FE (II) ION, ... | 著者 | Wu, L, Zhou, J.H. | 登録日 | 2021-08-10 | 公開日 | 2023-02-15 | 最終更新日 | 2024-09-04 | 実験手法 | X-RAY DIFFRACTION (1.83004665 Å) | 主引用文献 | Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis Nat Catal, 6, 2023
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5YNG
| Crystal structure of SZ348 in complex with cyclopentene oxide | 分子名称: | (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase, NICKEL (II) ION, ... | 著者 | Wu, L, Sun, Z.T, Reetz, M.T, Zhou, J.H. | 登録日 | 2017-10-24 | 公開日 | 2018-06-27 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | 主引用文献 | Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations. J. Am. Chem. Soc., 140, 2018
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6PT3
| Crystal structure of the active delta opioid receptor in complex with the small molecule agonist DPI-287 | 分子名称: | 4-[(R)-[(2S,5R)-4-benzyl-2,5-dimethylpiperazin-1-yl](3-hydroxyphenyl)methyl]-N,N-diethylbenzamide, Delta opioid receptor | 著者 | Claff, T, Yu, J, Blais, V, Patel, N, Martin, C, Wu, L, Han, G.W, Holleran, B.J, Van der Poorten, O, Hanson, M.A, Sarret, P, Gendron, L, Cherezov, V, Katritch, V, Ballet, S, Liu, Z, Muller, C.E, Stevens, R.C. | 登録日 | 2019-07-14 | 公開日 | 2019-12-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Elucidating the active delta-opioid receptor crystal structure with peptide and small-molecule agonists. Sci Adv, 5, 2019
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