6HZY

Crystal structure of a bacterial fucosidase with inhibitor FucPUG

Summary for 6HZY

• Entry DOI: 10.2210/pdb6hzy/pdb
• Descriptor: Alpha-L-fucosidase, 1,2-ETHANEDIOL, [(~{Z})-[(3~{S},4~{R},5~{S},6~{S})-6-methyl-3,4,5-tris(oxidanyl)oxan-2-ylidene]amino] ~{N}-phenylcarbamate, ... (5 entities in total)
• Functional Keywords: hydrolase
• Biological source: Bacteroides thetaiotaomicron VPI-5482
• Total number of polymer chains: 2
• Total formula weight: 111980.14

Authors

Wu, L.,Davies, G.J.,Stubbs, K.A.,Coyle, T.,Debowski, A.W. (deposition date: 2018-10-24, release date: 2019-02-20, Last modification date: 2024-01-24)

Primary citation

Coyle, T.,Wu, L.,Debowski, A.W.,Davies, G.J.,Stubbs, K.A.
Synthetic and Crystallographic Insight into Exploiting sp2Hybridization in the Development of alpha-l-Fucosidase Inhibitors.
Chembiochem, 20:1365-1368, 2019

PubMed Abstract: The sugar fucose plays a myriad of roles in biological recognition. Enzymes hydrolyzing fucose from glycoconjugates, α-l-fucosidases, are important targets for inhibitor and probe development. Here we describe the synthesis and evaluation of novel α-l-fucosidase inhibitors, with X-ray crystallographic analysis using an α-l-fucosidase from Bacteroides thetaiotamicron helping to lay a foundation for future development of inhibitors for this important enzyme class.

PubMed: 30663832
DOI: 10.1002/cbic.201800710

Experimental method

X-RAY DIFFRACTION (1.7 Å)