6GLW
 
 | | Structure of galectin-10 in complex with the Fab fragment of a Charcot-Leyden crystal solubilizing antibody, 1D11 | | 分子名称: | ACETATE ION, Fab 1D11 - Heavy chain, Fab 1D11 - Light chain, ... | | 著者 | Verstraete, K, Verschueren, K, Savvides, S.N. | | 登録日 | 2018-05-23 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GKT
 | | X-ray structure of a non-autocrystallizing galectin-10 variant, Gal10-Tyr69Glu | | 分子名称: | Galectin-10, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... | | 著者 | Verstraete, K, Verschueren, K, Savvides, S.N. | | 登録日 | 2018-05-21 | | 公開日 | 2019-06-05 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Protein crystallization promotes type 2 immunity and is reversible by antibody treatment.
Science, 364, 2019
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6GKQ
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6GKS
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8AV2
 | | Crystal structure for the FnIII module of mouse LEP-R in complex with the anti-LEP-R nanobody VHH-4.80 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin receptor, SULFATE ION, ... | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVC
 | | Mouse leptin:LEP-R complex cryoEM structure (3:3 model) | | 分子名称: | Leptin, Leptin receptor, NICKEL (II) ION | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVD
 | | Cryo-EM structure for a 3:3 complex between mouse leptin and the mouse LEP-R ectodomain (local refinement) | | 分子名称: | Leptin, Leptin receptor, NICKEL (II) ION | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (4.42 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVO
 | | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (open 3:3 model). | | 分子名称: | Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (6.84 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVE
 | | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (2:2 model) | | 分子名称: | Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (5.62 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVF
 | | Human leptin in complex with the human LEP-R ectodomain fused to a C-terminal trimeric isoleucine GCN4 zipper (closed 3:3 model) | | 分子名称: | Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (6.45 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8AVB
 | | Cryo-EM structure for mouse leptin in complex with the mouse LEP-R ectodomain (1:2 mLEP:mLEPR model). | | 分子名称: | Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-08-26 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-07-26 | | 実験手法 | ELECTRON MICROSCOPY (4.43 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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8B7Q
 | | Cryo-EM structure for the mouse LEPR-CRH2:Leptin:LEPR-Ig complex following symmetry expansion in combination with local refinement | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Leptin, Leptin receptor | | 著者 | Verstraete, K, Savvides, S.N, Verschueren, K.G, Tsirigotaki, A. | | 登録日 | 2022-09-30 | | 公開日 | 2023-04-05 | | 最終更新日 | 2023-04-26 | | 実験手法 | ELECTRON MICROSCOPY (4.02 Å) | | 主引用文献 | Mechanism of receptor assembly via the pleiotropic adipokine Leptin.
Nat.Struct.Mol.Biol., 30, 2023
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