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8SKQ
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BU of 8skq by Molmil
RNA oligonucleotide containing an alpha-(L)-threofuranosyl nucleic acid (TNA)
分子名称: TNA-containing RNA oligonucleotide
著者Harp, J.M, Egli, M.
登録日2023-04-20
公開日2024-02-14
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Shorter Is Better: The alpha-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.
J.Am.Chem.Soc., 145, 2023
1TNP
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BU of 1tnp by Molmil
STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH
分子名称: TROPONIN-C (APO)
著者Gagne, S.M, Sykes, B.D.
登録日1995-07-07
公開日1995-10-15
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structures of the troponin C regulatory domains in the apo and calcium-saturated states.
Nat.Struct.Biol., 2, 1995
1TNQ
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BU of 1tnq by Molmil
STRUCTURES OF THE APO AND CALCIUM TROPONIN-C REGULATORY DOMAINS: THE MUSCLE CONTRACTION SWITCH
分子名称: CALCIUM ION, TROPONIN-C
著者Gagne, S.M, Sykes, B.D.
登録日1995-07-07
公開日1995-10-15
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structures of the troponin C regulatory domains in the apo and calcium-saturated states.
Nat.Struct.Biol., 2, 1995
2EBS
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BU of 2ebs by Molmil
Crystal Structure Anaalysis of Oligoxyloglucan reducing-end-specific cellobiohydrolase (OXG-RCBH) D465N Mutant Complexed with a Xyloglucan Heptasaccharide
分子名称: Oligoxyloglucan reducing end-specific cellobiohydrolase, alpha-D-xylopyranose-(1-6)-beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-[alpha-D-xylopyranose-(1-6)]beta-D-glucopyranose-(1-4)-beta-D-glucopyranose
著者Yaoi, K, Kondo, H, Hiyoshi, A, Noro, N, Sugimoto, H, Miyazaki, K, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2007-02-09
公開日2007-06-26
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The Structural Basis for the Exo-mode of Action in GH74 Oligoxyloglucan Reducing End-specific Cellobiohydrolase.
J.Mol.Biol., 370, 2007
3RDN
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BU of 3rdn by Molmil
NMR STRUCTURE OF THE N-TERMINAL DOMAIN WITH A LINKER PORTION OF ANTARCTIC EEL POUT ANTIFREEZE PROTEIN RD3, MINIMIZED AVERAGE STRUCTURE
分子名称: ANTIFREEZE PROTEIN RD3 TYPE III
著者Miura, K, Ohgiya, S, Hoshino, T, Nemoto, N, Hikichi, K, Tsuda, S.
登録日1998-02-24
公開日1999-02-23
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural basis for the binding of a globular antifreeze protein to ice.
Nature, 384, 1996
3NLA
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BU of 3nla by Molmil
NMR STRUCTURE OF THE N-TERMINAL DOMAIN WITH A LINKER PORTION OF ANTARCTIC EEL POUT ANTIFREEZE PROTEIN RD3, 40 STRUCTURES
分子名称: ANTIFREEZE PROTEIN RD3 TYPE III
著者Miura, K, Ohgiya, S, Hoshino, T, Nemoto, N, Hikichi, K, Tsuda, S.
登録日1998-02-24
公開日1999-02-23
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structural basis for the binding of a globular antifreeze protein to ice.
Nature, 384, 1996
1WU3
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BU of 1wu3 by Molmil
Crystal structure of recombinant murine interferon beta
分子名称: Interferon beta
著者Senda, T, Saitoh, S, Mitsui, Y.
登録日2004-12-01
公開日2004-12-14
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Refined crystal structure of recombinant murine interferon-beta at 2.15 A resolution
J.Mol.Biol., 253, 1995
7XW8
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BU of 7xw8 by Molmil
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418 distomer, FAD-adduct
分子名称: GLYCEROL, Lysine-specific histone demethylase 1A, MAGNESIUM ION, ...
著者Oki, H.
登録日2022-05-26
公開日2022-10-12
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects.
Eur.J.Med.Chem., 239, 2022
6VEM
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BU of 6vem by Molmil
Structure of RNA octamer
分子名称: COBALT HEXAMMINE(III), Modified Octamer RNA
著者Pallan, P.S, Egli, M.
登録日2020-01-02
公開日2020-11-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine.
Nucleic Acids Res., 48, 2020
5VR4
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BU of 5vr4 by Molmil
RNA octamer containing 2'-F-4'-OMe U.
分子名称: COBALT TETRAAMMINE ION, RNA (5'-R(*CP*GP*AP*AP*(UMO)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2017-05-10
公開日2017-10-04
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献4'-C-Methoxy-2'-deoxy-2'-fluoro Modified Ribonucleotides Improve Metabolic Stability and Elicit Efficient RNAi-Mediated Gene Silencing.
J. Am. Chem. Soc., 139, 2017
7LO9
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BU of 7lo9 by Molmil
RNA dodecamer containing a GNA A residue
分子名称: Chains: A,B,C,D
著者Harp, J.M, Wawrzak, Z, Egli, M.
登録日2021-02-09
公開日2021-12-22
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs.
Nucleic Acids Res., 49, 2021
1HRF
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BU of 1hrf by Molmil
SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4
分子名称: HEREGULIN ALPHA
著者Nagata, K, Kohda, D, Hatanaka, H, Ichikawa, S, Inagaki, F.
登録日1994-07-21
公開日1994-10-15
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.
EMBO J., 13, 1994
1HRE
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BU of 1hre by Molmil
SOLUTION STRUCTURE OF THE EPIDERMAL GROWTH FACTOR-LIKE DOMAIN OF HEREGULIN-ALPHA, A LIGAND FOR P180ERB4
分子名称: HEREGULIN ALPHA
著者Nagata, K, Kohda, D, Hatanaka, H, Ichikawa, S, Inagaki, F.
登録日1994-07-21
公開日1994-10-15
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4.
EMBO J., 13, 1994
7E0G
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BU of 7e0g by Molmil
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418, FAD-adduct
分子名称: GLYCEROL, IMIDAZOLE, Lysine-specific histone demethylase 1A, ...
著者Oki, H.
登録日2021-01-28
公開日2021-03-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models.
Sci Adv, 7, 2021
6CY2
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BU of 6cy2 by Molmil
RNA octamer containing 2'-OMe, 4'Calpha-OMe U.
分子名称: RNA (5'-R(*(CBV)P*GP*AP*AP*(UOA)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY0
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BU of 6cy0 by Molmil
RNA octamer containing 2'-F, 4'-Cbeta-OMe U.
分子名称: RNA (5'-R(*(CBV)P*GP*AP*AP*(UFB)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.398 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CY4
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BU of 6cy4 by Molmil
RNA octamer containing 2'-OMe, 4'- Cbeta-OMe U.
分子名称: RNA (5'-R(*(CBV)P*GP*AP*AP*(UOB)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
6CXZ
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BU of 6cxz by Molmil
RNA octamer containing 2'-F, 4'-Calpha-Me U.
分子名称: CACODYLATE ION, COBALT HEXAMMINE(III), RNA (5'-R(*CP*GP*AP*AP*(U4M)P*UP*CP*G)-3')
著者Harp, J.M, Egli, M.
登録日2018-04-04
公開日2018-08-29
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for the synergy of 4'- and 2'-modifications on siRNA nuclease resistance, thermal stability and RNAi activity.
Nucleic Acids Res., 46, 2018
5BV6
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BU of 5bv6 by Molmil
PKG II's Carboxyl Terminal Cyclic Nucleotide Binding Domain (CNB-B) in a complex with cGMP
分子名称: ACETATE ION, CALCIUM ION, GUANOSINE-3',5'-MONOPHOSPHATE, ...
著者Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W.
登録日2015-06-04
公開日2016-01-20
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
5C6C
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BU of 5c6c by Molmil
PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cAMP
分子名称: 1,2-ETHANEDIOL, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, CADMIUM ION, ...
著者Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W.
登録日2015-06-22
公開日2016-01-20
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
5C8W
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BU of 5c8w by Molmil
PKG II's Amino Terminal Cyclic Nucleotide Binding Domain (CNB-A) in a complex with cGMP
分子名称: CYCLIC GUANOSINE MONOPHOSPHATE, MALONIC ACID, SODIUM ION, ...
著者Campbell, J.C, Reger, A.S, Huang, G.Y, Sankaran, B, Kim, J.J, Kim, C.W.
登録日2015-06-26
公開日2016-01-20
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II.
J.Biol.Chem., 291, 2016
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