7XW8
Crystal structure of Lysine Specific Demethylase 1 (LSD1) with TAK-418 distomer, FAD-adduct
Summary for 7XW8
Entry DOI | 10.2210/pdb7xw8/pdb |
Related | 7E0G |
Descriptor | Lysine-specific histone demethylase 1A, GLYCEROL, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | inhibitor, tak-418, distomer, fad-adduct, oxidoreductase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 75049.04 |
Authors | |
Primary citation | Hattori, Y.,Matsumoto, S.,Morimoto, S.,Daini, M.,Toyofuku, M.,Matsuda, S.,Baba, R.,Murakami, K.,Iwatani, M.,Oki, H.,Iwasaki, S.,Matsumiya, K.,Tominari, Y.,Kimura, H.,Ito, M. Design, synthesis, and structure-activity relationship of TAK-418 and its derivatives as a novel series of LSD1 inhibitors with lowered risk of hematological side effects. Eur.J.Med.Chem., 239:114522-114522, 2022 Cited by PubMed: 35749987DOI: 10.1016/j.ejmech.2022.114522 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.28 Å) |
Structure validation
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