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7DJC
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BU of 7djc by Molmil
Crystal structure of the G26C/Q250A mutant of LeuT
分子名称: LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
著者Fan, J, Xiao, Y, Sun, Z, Zhou, X.
登録日2020-11-20
公開日2021-04-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.701 Å)
主引用文献Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
7DJ1
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BU of 7dj1 by Molmil
Crystal structure of the G26C mutant of LeuT
分子名称: LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION
著者Fan, J, Xiao, Y, Sun, Z, Zhou, X.
登録日2020-11-19
公開日2021-04-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.528 Å)
主引用文献Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
7DII
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BU of 7dii by Molmil
Crystal structure of LeuT in lipidic cubic phase at pH 7
分子名称: LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION
著者Fan, J, Xiao, Y, Sun, Z, Zhou, X.
登録日2020-11-19
公開日2021-04-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.403 Å)
主引用文献Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
7DJ2
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BU of 7dj2 by Molmil
Crystal structure of the G26C/E290S mutant of LeuT
分子名称: LEUCINE, Na(+):neurotransmitter symporter (Snf family), SODIUM ION, ...
著者Fan, J, Xiao, Y, Sun, Z, Zhou, X.
登録日2020-11-19
公開日2021-04-07
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structures of LeuT reveal conformational dynamics in the outward-facing states.
J.Biol.Chem., 296, 2021
7CYG
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BU of 7cyg by Molmil
Crystal structure of a cysteine-pair mutant (Y113C-P190C) of a bacterial bile acid transporter before disulfide bond formation
分子名称: Transporter, sodium/bile acid symporter family
著者Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
登録日2020-09-03
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.198 Å)
主引用文献An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.
Acta Crystallogr D Struct Biol, 77, 2021
7CYK
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BU of 7cyk by Molmil
Crystal structure of a second cysteine-pair mutant (V110C-I197C) of a bacterial bile acid transporter before disulfide bond formation
分子名称: MERCURY (II) ION, Transporter, sodium/bile acid symporter family
著者Wang, X, Lyu, Y, Ji, Y, Sun, Z, Zhou, X.
登録日2020-09-03
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.785 Å)
主引用文献An engineered disulfide bridge traps and validates an outward-facing conformation in a bile acid transporter.
Acta Crystallogr D Struct Biol, 77, 2021
7Y9B
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BU of 7y9b by Molmil
Crystal structure of the membrane (M) protein of a SARS-COV-2-related coronavirus
分子名称: 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, Membrane protein
著者Wang, X, Sun, Z, Zhou, X.
登録日2022-06-24
公開日2022-08-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.214 Å)
主引用文献Crystal structure of the membrane (M) protein from a bat betacoronavirus.
Pnas Nexus, 2, 2023
7Y96
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Crystal structure of the carboxy-terminal domain of a coronavirus M protein fused with a split GFP
分子名称: Green fluorescent protein,Membrane protein
著者Wang, X, Sun, Z, Zhou, X.
登録日2022-06-24
公開日2022-08-17
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.415 Å)
主引用文献Crystal structure of the membrane (M) protein from a bat betacoronavirus.
Pnas Nexus, 2, 2023
7W2B
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BU of 7w2b by Molmil
The closed conformation of the sigma-1 receptor from Xenopus laevis
分子名称: GOLD ION, Sigma non-opioid intracellular receptor 1, octyl beta-D-glucopyranoside
著者Meng, F, Sun, Z, Zhou, X.
登録日2021-11-23
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.203 Å)
主引用文献An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2H
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A double cysteine variant of the sigma-1 receptor from Xenopus laevis complexed with S1RA
分子名称: 4-[2-(5-methyl-1-naphthalen-2-yl-pyrazol-3-yl)oxyethyl]morpholine, Sigma non-opioid intracellular receptor 1
著者Meng, F, Sun, Z, Zhou, X.
登録日2021-11-23
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.796 Å)
主引用文献An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2C
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The closed conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084
分子名称: 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, GOLD ION, Sigma non-opioid intracellular receptor 1, ...
著者Meng, F, Sun, Z, Zhou, X.
登録日2021-11-23
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.335 Å)
主引用文献An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2E
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An open-like conformation of the sigma-1 receptor from Xenopus laevis
分子名称: Sigma non-opioid intracellular receptor 1
著者Meng, F, Sun, Z, Zhou, X.
登録日2021-11-23
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.557 Å)
主引用文献An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2G
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BU of 7w2g by Molmil
An open-like conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 by soaking
分子名称: 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, Sigma non-opioid intracellular receptor 1, octyl beta-D-glucopyranoside
著者Meng, F, Sun, Z, Zhou, X.
登録日2021-11-23
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.851 Å)
主引用文献An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2F
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BU of 7w2f by Molmil
An open-like conformation of the sigma-1 receptor from Xenopus laevis complexed with PRE084 by co-crystallization
分子名称: 2-morpholin-4-ylethyl 1-phenylcyclohexane-1-carboxylate, Sigma non-opioid intracellular receptor 1, octyl beta-D-glucopyranoside
著者Meng, F, Sun, Z, Zhou, X.
登録日2021-11-23
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
7W2D
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BU of 7w2d by Molmil
The closed conformation of the sigma-1 receptor from Xenopus laevis complexed with S1RA
分子名称: 4-[2-(5-methyl-1-naphthalen-2-yl-pyrazol-3-yl)oxyethyl]morpholine, GOLD ION, Sigma non-opioid intracellular receptor 1
著者Meng, F, Sun, Z, Zhou, X.
登録日2021-11-23
公開日2022-03-16
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.471 Å)
主引用文献An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.
Nat Commun, 13, 2022
5WUU
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BU of 5wuu by Molmil
Complex structure of the first bromodomain of BRD4 with an inhibitor that containing a 2H-chromen-2-one ring
分子名称: Bromodomain-containing protein 4, ~{N}-methyl-~{N}-[3-[(2-oxidanylidenechromen-4-yl)amino]propyl]thiophene-2-carboxamide
著者Zhang, H, Sun, Z.Y.
登録日2016-12-21
公開日2017-04-12
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.724 Å)
主引用文献Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.
Bioorg. Med. Chem. Lett., 27, 2017
6KX3
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BU of 6kx3 by Molmil
Crystal structure of RhoA protein with covalent inhibitor DC-Rhoin
分子名称: GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, prop-2-enyl (3R)-1,1-bis(oxidanylidene)-2,3-dihydro-1-benzothiophene-3-carboxylate
著者Zhang, H, Luo, C.
登録日2019-09-09
公開日2020-08-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.981 Å)
主引用文献Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Adv Sci, 7, 2020
6KX2
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BU of 6kx2 by Molmil
Crystal structure of GDP bound RhoA protein
分子名称: GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA
著者Zhang, H, Luo, C.
登録日2019-09-09
公開日2020-08-19
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.454 Å)
主引用文献Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion.
Adv Sci, 7, 2020
5YAO
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BU of 5yao by Molmil
The complex structure of SZ529 and expoxid
分子名称: (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase, SODIUM ION
著者Lian, W, Sun, Z.T, Zhou, J.H, Reetz, M.T.
登録日2017-09-01
公開日2018-06-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.611 Å)
主引用文献Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations
J. Am. Chem. Soc., 140, 2018
5YNG
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BU of 5yng by Molmil
Crystal structure of SZ348 in complex with cyclopentene oxide
分子名称: (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase, NICKEL (II) ION, ...
著者Wu, L, Sun, Z.T, Reetz, M.T, Zhou, J.H.
登録日2017-10-24
公開日2018-06-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.497 Å)
主引用文献Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.
J. Am. Chem. Soc., 140, 2018
5YQT
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BU of 5yqt by Molmil
Crystal Structure of the L74F/M78V/I80V/L114F mutant of LEH complexed with cyclopentene oxide
分子名称: (1R,5S)-6-oxabicyclo[3.1.0]hexane, Limonene-1,2-epoxide hydrolase
著者Kong, X.D, Sun, Z.T, Wu, L, Reetz, M.T, Zhou, J.H, Xu, J.H.
登録日2017-11-07
公開日2018-06-27
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations.
J. Am. Chem. Soc., 140, 2018
4IKG
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BU of 4ikg by Molmil
Crystal structure of cell death-inducing DFFA-like effector c
分子名称: Cell death activator CIDE-3, IODIDE ION
著者Yang, M, Gao, J.
登録日2012-12-26
公開日2014-06-04
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.9318 Å)
主引用文献Perilipin1 promotes unilocular lipid droplet formation through the activation of Fsp27 in adipocytes.
Nat Commun, 4, 2013
7VFB
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BU of 7vfb by Molmil
the complex of SARS-CoV2 3cl and NB2B4
分子名称: 3C-like proteinase, nb2b4
著者Geng, Y, Sun, Z.C, Wang, L.
登録日2021-09-11
公開日2022-03-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An extended conformation of SARS-CoV-2 main protease reveals allosteric targets.
Proc.Natl.Acad.Sci.USA, 119, 2022
7VFA
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the complex of SARS-CoV2 3CL and NB1A2
分子名称: 3C-like proteinase, NB1A2, SULFATE ION
著者Sun, Z.C, Wang, L, Geng, Y.
登録日2021-09-11
公開日2022-03-30
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献An extended conformation of SARS-CoV-2 main protease reveals allosteric targets.
Proc.Natl.Acad.Sci.USA, 119, 2022
8FSL
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Human Mesothelin bound to a neutralizing VH domain antibody
分子名称: Mesothelin, VH domain
著者Calero, G.
登録日2023-01-10
公開日2024-05-29
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate.
Mol Ther Oncolytics, 31, 2023

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