7W2H

A double cysteine variant of the sigma-1 receptor from Xenopus laevis complexed with S1RA

Summary for 7W2H

• Entry DOI: 10.2210/pdb7w2h/pdb
• Descriptor: Sigma non-opioid intracellular receptor 1, 4-[2-(5-methyl-1-naphthalen-2-yl-pyrazol-3-yl)oxyethyl]morpholine (2 entities in total)
• Functional Keywords: sigma receptor, membrane receptor, s1r, ligand entry, membrane protein
• Biological source: Xenopus laevis (African clawed frog)
• Total number of polymer chains: 24
• Total formula weight: 609674.64

Authors

Meng, F.,Sun, Z.,Zhou, X. (deposition date: 2021-11-23, release date: 2022-03-16, Last modification date: 2023-11-29)

• Primary citation: Meng, F.,Xiao, Y.,Ji, Y.,Sun, Z.,Zhou, X.; An open-like conformation of the sigma-1 receptor reveals its ligand entry pathway.; Nat Commun, 13:1267-1267, 2022; PubMed: 35273182; DOI: 10.1038/s41467-022-28946-w

Experimental method

X-RAY DIFFRACTION (3.796 Å)