7W2H

A double cysteine variant of the sigma-1 receptor from Xenopus laevis complexed with S1RA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005635	cellular_component	nuclear envelope
A	0005637	cellular_component	nuclear inner membrane
A	0005640	cellular_component	nuclear outer membrane
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0038023	molecular_function	signaling receptor activity
A	0043523	biological_process	regulation of neuron apoptotic process
A	1905897	biological_process	regulation of response to endoplasmic reticulum stress
B	0005635	cellular_component	nuclear envelope
B	0005637	cellular_component	nuclear inner membrane
B	0005640	cellular_component	nuclear outer membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0038023	molecular_function	signaling receptor activity
B	0043523	biological_process	regulation of neuron apoptotic process
B	1905897	biological_process	regulation of response to endoplasmic reticulum stress
C	0005635	cellular_component	nuclear envelope
C	0005637	cellular_component	nuclear inner membrane
C	0005640	cellular_component	nuclear outer membrane
C	0005783	cellular_component	endoplasmic reticulum
C	0005789	cellular_component	endoplasmic reticulum membrane
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0038023	molecular_function	signaling receptor activity
C	0043523	biological_process	regulation of neuron apoptotic process
C	1905897	biological_process	regulation of response to endoplasmic reticulum stress
D	0005635	cellular_component	nuclear envelope
D	0005637	cellular_component	nuclear inner membrane
D	0005640	cellular_component	nuclear outer membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005789	cellular_component	endoplasmic reticulum membrane
D	0014069	cellular_component	postsynaptic density
D	0016020	cellular_component	membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0038023	molecular_function	signaling receptor activity
D	0043523	biological_process	regulation of neuron apoptotic process
D	1905897	biological_process	regulation of response to endoplasmic reticulum stress
E	0005635	cellular_component	nuclear envelope
E	0005637	cellular_component	nuclear inner membrane
E	0005640	cellular_component	nuclear outer membrane
E	0005783	cellular_component	endoplasmic reticulum
E	0005789	cellular_component	endoplasmic reticulum membrane
E	0014069	cellular_component	postsynaptic density
E	0016020	cellular_component	membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0038023	molecular_function	signaling receptor activity
E	0043523	biological_process	regulation of neuron apoptotic process
E	1905897	biological_process	regulation of response to endoplasmic reticulum stress
F	0005635	cellular_component	nuclear envelope
F	0005637	cellular_component	nuclear inner membrane
F	0005640	cellular_component	nuclear outer membrane
F	0005783	cellular_component	endoplasmic reticulum
F	0005789	cellular_component	endoplasmic reticulum membrane
F	0014069	cellular_component	postsynaptic density
F	0016020	cellular_component	membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0038023	molecular_function	signaling receptor activity
F	0043523	biological_process	regulation of neuron apoptotic process
F	1905897	biological_process	regulation of response to endoplasmic reticulum stress
G	0005635	cellular_component	nuclear envelope
G	0005637	cellular_component	nuclear inner membrane
G	0005640	cellular_component	nuclear outer membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005789	cellular_component	endoplasmic reticulum membrane
G	0014069	cellular_component	postsynaptic density
G	0016020	cellular_component	membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0038023	molecular_function	signaling receptor activity
G	0043523	biological_process	regulation of neuron apoptotic process
G	1905897	biological_process	regulation of response to endoplasmic reticulum stress
H	0005635	cellular_component	nuclear envelope
H	0005637	cellular_component	nuclear inner membrane
H	0005640	cellular_component	nuclear outer membrane
H	0005783	cellular_component	endoplasmic reticulum
H	0005789	cellular_component	endoplasmic reticulum membrane
H	0014069	cellular_component	postsynaptic density
H	0016020	cellular_component	membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0038023	molecular_function	signaling receptor activity
H	0043523	biological_process	regulation of neuron apoptotic process
H	1905897	biological_process	regulation of response to endoplasmic reticulum stress
I	0005635	cellular_component	nuclear envelope
I	0005637	cellular_component	nuclear inner membrane
I	0005640	cellular_component	nuclear outer membrane
I	0005783	cellular_component	endoplasmic reticulum
I	0005789	cellular_component	endoplasmic reticulum membrane
I	0014069	cellular_component	postsynaptic density
I	0016020	cellular_component	membrane
I	0031410	cellular_component	cytoplasmic vesicle
I	0038023	molecular_function	signaling receptor activity
I	0043523	biological_process	regulation of neuron apoptotic process
I	1905897	biological_process	regulation of response to endoplasmic reticulum stress
J	0005635	cellular_component	nuclear envelope
J	0005637	cellular_component	nuclear inner membrane
J	0005640	cellular_component	nuclear outer membrane
J	0005783	cellular_component	endoplasmic reticulum
J	0005789	cellular_component	endoplasmic reticulum membrane
J	0014069	cellular_component	postsynaptic density
J	0016020	cellular_component	membrane
J	0031410	cellular_component	cytoplasmic vesicle
J	0038023	molecular_function	signaling receptor activity
J	0043523	biological_process	regulation of neuron apoptotic process
J	1905897	biological_process	regulation of response to endoplasmic reticulum stress
K	0005635	cellular_component	nuclear envelope
K	0005637	cellular_component	nuclear inner membrane
K	0005640	cellular_component	nuclear outer membrane
K	0005783	cellular_component	endoplasmic reticulum
K	0005789	cellular_component	endoplasmic reticulum membrane
K	0014069	cellular_component	postsynaptic density
K	0016020	cellular_component	membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0038023	molecular_function	signaling receptor activity
K	0043523	biological_process	regulation of neuron apoptotic process
K	1905897	biological_process	regulation of response to endoplasmic reticulum stress
L	0005635	cellular_component	nuclear envelope
L	0005637	cellular_component	nuclear inner membrane
L	0005640	cellular_component	nuclear outer membrane
L	0005783	cellular_component	endoplasmic reticulum
L	0005789	cellular_component	endoplasmic reticulum membrane
L	0014069	cellular_component	postsynaptic density
L	0016020	cellular_component	membrane
L	0031410	cellular_component	cytoplasmic vesicle
L	0038023	molecular_function	signaling receptor activity
L	0043523	biological_process	regulation of neuron apoptotic process
L	1905897	biological_process	regulation of response to endoplasmic reticulum stress
M	0005635	cellular_component	nuclear envelope
M	0005637	cellular_component	nuclear inner membrane
M	0005640	cellular_component	nuclear outer membrane
M	0005783	cellular_component	endoplasmic reticulum
M	0005789	cellular_component	endoplasmic reticulum membrane
M	0014069	cellular_component	postsynaptic density
M	0016020	cellular_component	membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0038023	molecular_function	signaling receptor activity
M	0043523	biological_process	regulation of neuron apoptotic process
M	1905897	biological_process	regulation of response to endoplasmic reticulum stress
N	0005635	cellular_component	nuclear envelope
N	0005637	cellular_component	nuclear inner membrane
N	0005640	cellular_component	nuclear outer membrane
N	0005783	cellular_component	endoplasmic reticulum
N	0005789	cellular_component	endoplasmic reticulum membrane
N	0014069	cellular_component	postsynaptic density
N	0016020	cellular_component	membrane
N	0031410	cellular_component	cytoplasmic vesicle
N	0038023	molecular_function	signaling receptor activity
N	0043523	biological_process	regulation of neuron apoptotic process
N	1905897	biological_process	regulation of response to endoplasmic reticulum stress
O	0005635	cellular_component	nuclear envelope
O	0005637	cellular_component	nuclear inner membrane
O	0005640	cellular_component	nuclear outer membrane
O	0005783	cellular_component	endoplasmic reticulum
O	0005789	cellular_component	endoplasmic reticulum membrane
O	0014069	cellular_component	postsynaptic density
O	0016020	cellular_component	membrane
O	0031410	cellular_component	cytoplasmic vesicle
O	0038023	molecular_function	signaling receptor activity
O	0043523	biological_process	regulation of neuron apoptotic process
O	1905897	biological_process	regulation of response to endoplasmic reticulum stress
P	0005635	cellular_component	nuclear envelope
P	0005637	cellular_component	nuclear inner membrane
P	0005640	cellular_component	nuclear outer membrane
P	0005783	cellular_component	endoplasmic reticulum
P	0005789	cellular_component	endoplasmic reticulum membrane
P	0014069	cellular_component	postsynaptic density
P	0016020	cellular_component	membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0038023	molecular_function	signaling receptor activity
P	0043523	biological_process	regulation of neuron apoptotic process
P	1905897	biological_process	regulation of response to endoplasmic reticulum stress
Q	0005635	cellular_component	nuclear envelope
Q	0005637	cellular_component	nuclear inner membrane
Q	0005640	cellular_component	nuclear outer membrane
Q	0005783	cellular_component	endoplasmic reticulum
Q	0005789	cellular_component	endoplasmic reticulum membrane
Q	0014069	cellular_component	postsynaptic density
Q	0016020	cellular_component	membrane
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0038023	molecular_function	signaling receptor activity
Q	0043523	biological_process	regulation of neuron apoptotic process
Q	1905897	biological_process	regulation of response to endoplasmic reticulum stress
R	0005635	cellular_component	nuclear envelope
R	0005637	cellular_component	nuclear inner membrane
R	0005640	cellular_component	nuclear outer membrane
R	0005783	cellular_component	endoplasmic reticulum
R	0005789	cellular_component	endoplasmic reticulum membrane
R	0014069	cellular_component	postsynaptic density
R	0016020	cellular_component	membrane
R	0031410	cellular_component	cytoplasmic vesicle
R	0038023	molecular_function	signaling receptor activity
R	0043523	biological_process	regulation of neuron apoptotic process
R	1905897	biological_process	regulation of response to endoplasmic reticulum stress
S	0005635	cellular_component	nuclear envelope
S	0005637	cellular_component	nuclear inner membrane
S	0005640	cellular_component	nuclear outer membrane
S	0005783	cellular_component	endoplasmic reticulum
S	0005789	cellular_component	endoplasmic reticulum membrane
S	0014069	cellular_component	postsynaptic density
S	0016020	cellular_component	membrane
S	0031410	cellular_component	cytoplasmic vesicle
S	0038023	molecular_function	signaling receptor activity
S	0043523	biological_process	regulation of neuron apoptotic process
S	1905897	biological_process	regulation of response to endoplasmic reticulum stress
T	0005635	cellular_component	nuclear envelope
T	0005637	cellular_component	nuclear inner membrane
T	0005640	cellular_component	nuclear outer membrane
T	0005783	cellular_component	endoplasmic reticulum
T	0005789	cellular_component	endoplasmic reticulum membrane
T	0014069	cellular_component	postsynaptic density
T	0016020	cellular_component	membrane
T	0031410	cellular_component	cytoplasmic vesicle
T	0038023	molecular_function	signaling receptor activity
T	0043523	biological_process	regulation of neuron apoptotic process
T	1905897	biological_process	regulation of response to endoplasmic reticulum stress
U	0005635	cellular_component	nuclear envelope
U	0005637	cellular_component	nuclear inner membrane
U	0005640	cellular_component	nuclear outer membrane
U	0005783	cellular_component	endoplasmic reticulum
U	0005789	cellular_component	endoplasmic reticulum membrane
U	0014069	cellular_component	postsynaptic density
U	0016020	cellular_component	membrane
U	0031410	cellular_component	cytoplasmic vesicle
U	0038023	molecular_function	signaling receptor activity
U	0043523	biological_process	regulation of neuron apoptotic process
U	1905897	biological_process	regulation of response to endoplasmic reticulum stress
V	0005635	cellular_component	nuclear envelope
V	0005637	cellular_component	nuclear inner membrane
V	0005640	cellular_component	nuclear outer membrane
V	0005783	cellular_component	endoplasmic reticulum
V	0005789	cellular_component	endoplasmic reticulum membrane
V	0014069	cellular_component	postsynaptic density
V	0016020	cellular_component	membrane
V	0031410	cellular_component	cytoplasmic vesicle
V	0038023	molecular_function	signaling receptor activity
V	0043523	biological_process	regulation of neuron apoptotic process
V	1905897	biological_process	regulation of response to endoplasmic reticulum stress
W	0005635	cellular_component	nuclear envelope
W	0005637	cellular_component	nuclear inner membrane
W	0005640	cellular_component	nuclear outer membrane
W	0005783	cellular_component	endoplasmic reticulum
W	0005789	cellular_component	endoplasmic reticulum membrane
W	0014069	cellular_component	postsynaptic density
W	0016020	cellular_component	membrane
W	0031410	cellular_component	cytoplasmic vesicle
W	0038023	molecular_function	signaling receptor activity
W	0043523	biological_process	regulation of neuron apoptotic process
W	1905897	biological_process	regulation of response to endoplasmic reticulum stress
X	0005635	cellular_component	nuclear envelope
X	0005637	cellular_component	nuclear inner membrane
X	0005640	cellular_component	nuclear outer membrane
X	0005783	cellular_component	endoplasmic reticulum
X	0005789	cellular_component	endoplasmic reticulum membrane
X	0014069	cellular_component	postsynaptic density
X	0016020	cellular_component	membrane
X	0031410	cellular_component	cytoplasmic vesicle
X	0038023	molecular_function	signaling receptor activity
X	0043523	biological_process	regulation of neuron apoptotic process
X	1905897	biological_process	regulation of response to endoplasmic reticulum stress

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	264
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"UniProtKB","id":"Q99720","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	168
Details	Region: {"description":"Important for ligand-binding","evidences":[{"source":"UniProtKB","id":"Q60492","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Site: {"description":"Important for ligand binding","evidences":[{"source":"UniProtKB","id":"Q99720","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---