8FSL

Human Mesothelin bound to a neutralizing VH domain antibody

Summary for 8FSL

Entry DOI	10.2210/pdb8fsl/pdb
Descriptor	VH domain, Mesothelin (2 entities in total)
Functional Keywords	mesothelin vh, antitumor protein
Biological source	Escherichia coli More
Total number of polymer chains	6
Total formula weight	115563.07
Authors	Calero, G. (deposition date: 2023-01-10, release date: 2024-05-29)
Primary citation	Sun, Z.,Chu, X.,Adams, C.,Ilina, T.V.,Guerrero, M.,Lin, G.,Chen, C.,Jelev, D.,Ishima, R.,Li, W.,Mellors, J.W.,Calero, G.,Dimitrov, D.S. Preclinical assessment of a novel human antibody VH domain targeting mesothelin as an antibody-drug conjugate. Mol Ther Oncolytics, 31:100726-100726, 2023 Cited by PubMed: 37771390 DOI: 10.1016/j.omto.2023.09.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation