8ETM
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![BU of 8etm by Molmil](/molmil-images/mine/8etm) | Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor | 分子名称: | Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid | 著者 | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | 登録日 | 2022-10-17 | 公開日 | 2023-06-07 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
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6XOG
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![BU of 6xog by Molmil](/molmil-images/mine/6xog) | Structure of SUMO1-ML786519 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6XOH
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![BU of 6xoh by Molmil](/molmil-images/mine/6xoh) | Structure of SUMO1-ML00789344 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.226 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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6XOI
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![BU of 6xoi by Molmil](/molmil-images/mine/6xoi) | Structure of SUMO1-ML00752641 adduct bound to SAE | 分子名称: | SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ... | 著者 | Sintchak, M, Lane, W, Bump, N. | 登録日 | 2020-07-07 | 公開日 | 2021-03-24 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer. J.Med.Chem., 64, 2021
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8FDW
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![BU of 8fdw by Molmil](/molmil-images/mine/8fdw) | Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S2, ... | 著者 | Zhang, J, Shi, W, Cai, Y.F, Zhu, H.S, Peng, H.Q, Voyer, J, Volloch, S.R, Cao, H, Mayer, M.L, Song, K.K, Xu, C, Lu, J.M, Chen, B. | 登録日 | 2022-12-05 | 公開日 | 2023-05-10 | 最終更新日 | 2023-07-26 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane. Nature, 619, 2023
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4TUM
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![BU of 4tum by Molmil](/molmil-images/mine/4tum) | |
8EFP
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![BU of 8efp by Molmil](/molmil-images/mine/8efp) | |
8ET1
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![BU of 8et1 by Molmil](/molmil-images/mine/8et1) | |
8ET2
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![BU of 8et2 by Molmil](/molmil-images/mine/8et2) | CryoEM structure of the GSDMB pore | 分子名称: | Isoform 1 of Gasdermin-B | 著者 | Wang, C, Ruan, J. | 登録日 | 2022-10-15 | 公開日 | 2023-03-29 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4.96 Å) | 主引用文献 | Structural basis for GSDMB pore formation and its targeting by IpaH7.8. Nature, 616, 2023
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7N85
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![BU of 7n85 by Molmil](/molmil-images/mine/7n85) | Inner ring spoke from the isolated yeast NPC | 分子名称: | Nucleoporin ASM4, Nucleoporin NIC96, Nucleoporin NSP1, ... | 著者 | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | 登録日 | 2021-06-13 | 公開日 | 2022-01-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (7.6 Å) | 主引用文献 | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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7N84
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![BU of 7n84 by Molmil](/molmil-images/mine/7n84) | Double nuclear outer ring from the isolated yeast NPC | 分子名称: | Nucleoporin 145c, Nucleoporin NUP120, Nucleoporin NUP133, ... | 著者 | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | 登録日 | 2021-06-13 | 公開日 | 2022-01-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (11.6 Å) | 主引用文献 | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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7N9F
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![BU of 7n9f by Molmil](/molmil-images/mine/7n9f) | Structure of the in situ yeast NPC | 分子名称: | Dynein light chain 1, cytoplasmic, Nucleoporin 145c, ... | 著者 | Villa, E, Singh, D, Ludtke, S.J, Akey, C.W, Rout, M.P, Echeverria, I, Suslov, S. | 登録日 | 2021-06-17 | 公開日 | 2022-01-26 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (37 Å) | 主引用文献 | Comprehensive structure and functional adaptations of the yeast nuclear pore complex. Cell, 185, 2022
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7T3A
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![BU of 7t3a by Molmil](/molmil-images/mine/7t3a) | GATOR1-RAG-RAGULATOR - Inhibitory Complex | 分子名称: | GATOR complex protein DEPDC5, GATOR complex protein NPRL2, GATOR complex protein NPRL3, ... | 著者 | Egri, S.B, Shen, K. | 登録日 | 2021-12-07 | 公開日 | 2022-04-06 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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7T3B
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![BU of 7t3b by Molmil](/molmil-images/mine/7t3b) | GATOR1-RAG-RAGULATOR - GAP Complex | 分子名称: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | 著者 | Egri, S.B, Shen, K. | 登録日 | 2021-12-07 | 公開日 | 2022-04-06 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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7T3C
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![BU of 7t3c by Molmil](/molmil-images/mine/7t3c) | GATOR1-RAG-RAGULATOR - Dual Complex | 分子名称: | ALUMINUM FLUORIDE, GATOR complex protein DEPDC5, GATOR complex protein NPRL2, ... | 著者 | Egri, S.B, Shen, K. | 登録日 | 2021-12-07 | 公開日 | 2022-04-06 | 最終更新日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Cryo-EM structures of the human GATOR1-Rag-Ragulator complex reveal a spatial-constraint regulated GAP mechanism. Mol.Cell, 82, 2022
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7B42
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![BU of 7b42 by Molmil](/molmil-images/mine/7b42) | Crystal structure of c-MET bound by compound 8 | 分子名称: | 3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2020-12-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B3Q
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![BU of 7b3q by Molmil](/molmil-images/mine/7b3q) | Crystal structure of c-MET bound by compound 1 | 分子名称: | 1-(phenylmethyl)-5~{H}-pyrrolo[3,2-c]pyridin-4-one, Hepatocyte growth factor receptor, SULFATE ION | 著者 | Collie, G.W. | 登録日 | 2020-12-01 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B40
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![BU of 7b40 by Molmil](/molmil-images/mine/7b40) | Crystal structure of c-MET bound by compound 6 | 分子名称: | 3-(phenylmethyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2020-12-01 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B3W
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![BU of 7b3w by Molmil](/molmil-images/mine/7b3w) | Crystal structure of c-MET bound by compound 4 | 分子名称: | 1,2-ETHANEDIOL, 3-(6-fluoranyl-1~{H}-indazol-4-yl)-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2020-12-01 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B43
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![BU of 7b43 by Molmil](/molmil-images/mine/7b43) | Crystal structure of c-MET bound by compound 9 | 分子名称: | 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2020-12-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B3Z
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![BU of 7b3z by Molmil](/molmil-images/mine/7b3z) | Crystal structure of c-MET bound by compound 5 | 分子名称: | 3-[3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, DIMETHYL SULFOXIDE, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2020-12-01 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B3V
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![BU of 7b3v by Molmil](/molmil-images/mine/7b3v) | Crystal structure of c-MET bound by compound 3 | 分子名称: | 3-(3-methyl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2020-12-01 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B44
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![BU of 7b44 by Molmil](/molmil-images/mine/7b44) | Crystal structure of c-MET bound by compound S1 | 分子名称: | 5-methoxy-1~{H}-indazole, DIMETHYL SULFOXIDE, Hepatocyte growth factor receptor, ... | 著者 | Collie, G.W. | 登録日 | 2020-12-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B3T
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![BU of 7b3t by Molmil](/molmil-images/mine/7b3t) | Crystal structure of c-MET bound by compound 2 | 分子名称: | 3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridine, CHLORIDE ION, Hepatocyte growth factor receptor, ... | 著者 | Collie, G.W. | 登録日 | 2020-12-01 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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7B41
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![BU of 7b41 by Molmil](/molmil-images/mine/7b41) | Crystal structure of c-MET bound by compound 7 | 分子名称: | 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor | 著者 | Collie, G.W. | 登録日 | 2020-12-02 | 公開日 | 2020-12-09 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Structural Basis for Targeting the Folded P-Loop Conformation of c-MET. Acs Med.Chem.Lett., 12, 2021
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