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8BI2
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BU of 8bi2 by Molmil
Syk kinase domain in complex with macrocyclic inhibitor 20a
分子名称: 10,13,23-trimethyl-16-oxa-2,4,8,9,13,19,23,30-octazapentacyclo[19.5.2.1^{3,7}.1^{8,11}.0^{24,28}]triaconta-1(27),3,5,7(30),9,11(29),21,24(28),25-nonaen-20-one, Tyrosine-protein kinase SYK
著者Read, J.A, Patel, J.
登録日2022-11-01
公開日2023-06-14
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.508 Å)
主引用文献Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorg.Med.Chem.Lett., 91, 2023
6XOG
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BU of 6xog by Molmil
Structure of SUMO1-ML786519 adduct bound to SAE
分子名称: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
著者Sintchak, M, Lane, W, Bump, N.
登録日2020-07-07
公開日2021-03-10
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
6XOH
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BU of 6xoh by Molmil
Structure of SUMO1-ML00789344 adduct bound to SAE
分子名称: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
著者Sintchak, M, Lane, W, Bump, N.
登録日2020-07-07
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.226 Å)
主引用文献Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
6XOI
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BU of 6xoi by Molmil
Structure of SUMO1-ML00752641 adduct bound to SAE
分子名称: SULFATE ION, SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, ...
著者Sintchak, M, Lane, W, Bump, N.
登録日2020-07-07
公開日2021-03-24
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer.
J.Med.Chem., 64, 2021
7B42
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BU of 7b42 by Molmil
Crystal structure of c-MET bound by compound 8
分子名称: 3-[(3-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
著者Collie, G.W.
登録日2020-12-02
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3Q
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BU of 7b3q by Molmil
Crystal structure of c-MET bound by compound 1
分子名称: 1-(phenylmethyl)-5~{H}-pyrrolo[3,2-c]pyridin-4-one, Hepatocyte growth factor receptor, SULFATE ION
著者Collie, G.W.
登録日2020-12-01
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B40
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BU of 7b40 by Molmil
Crystal structure of c-MET bound by compound 6
分子名称: 3-(phenylmethyl)-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
著者Collie, G.W.
登録日2020-12-01
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3W
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BU of 7b3w by Molmil
Crystal structure of c-MET bound by compound 4
分子名称: 1,2-ETHANEDIOL, 3-(6-fluoranyl-1~{H}-indazol-4-yl)-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor
著者Collie, G.W.
登録日2020-12-01
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B43
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BU of 7b43 by Molmil
Crystal structure of c-MET bound by compound 9
分子名称: 3-[(4-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
著者Collie, G.W.
登録日2020-12-02
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3Z
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BU of 7b3z by Molmil
Crystal structure of c-MET bound by compound 5
分子名称: 3-[3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridin-5-yl]-4,5-dihydro-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, DIMETHYL SULFOXIDE, Hepatocyte growth factor receptor
著者Collie, G.W.
登録日2020-12-01
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3V
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BU of 7b3v by Molmil
Crystal structure of c-MET bound by compound 3
分子名称: 3-(3-methyl-1~{H}-pyrrolo[2,3-b]pyridin-5-yl)-1~{H}-pyrrolo[3,4-b]pyrrol-6-one, Hepatocyte growth factor receptor
著者Collie, G.W.
登録日2020-12-01
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B44
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BU of 7b44 by Molmil
Crystal structure of c-MET bound by compound S1
分子名称: 5-methoxy-1~{H}-indazole, DIMETHYL SULFOXIDE, Hepatocyte growth factor receptor, ...
著者Collie, G.W.
登録日2020-12-02
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B3T
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BU of 7b3t by Molmil
Crystal structure of c-MET bound by compound 2
分子名称: 3-(phenylmethyl)-1~{H}-pyrrolo[2,3-b]pyridine, CHLORIDE ION, Hepatocyte growth factor receptor, ...
著者Collie, G.W.
登録日2020-12-01
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
7B41
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BU of 7b41 by Molmil
Crystal structure of c-MET bound by compound 7
分子名称: 3-[(2-fluorophenyl)methyl]-5-(1-piperidin-4-ylpyrazol-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, Hepatocyte growth factor receptor
著者Collie, G.W.
登録日2020-12-02
公開日2020-12-09
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
Acs Med.Chem.Lett., 12, 2021
6IKM
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BU of 6ikm by Molmil
Crystal structure of SpuE-Spermidine in complex with ScFv5
分子名称: Polyamine transport protein, SPERMIDINE, SULFATE ION, ...
著者Wu, D, Sun, X.
登録日2018-10-16
公開日2019-12-25
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (3.398 Å)
主引用文献A Potent Anti-SpuE Antibody Allosterically Inhibits Type III Secretion System and Attenuates Virulence of Pseudomonas Aeruginosa.
J.Mol.Biol., 431, 2019
8EFP
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BU of 8efp by Molmil
CryoEM structure of GSDMB in complex with shigella IpaH7.8
分子名称: Gasdermin-B, Probable E3 ubiquitin-protein ligase ipaH7.8
著者Wang, C, Ruan, J.
登録日2022-09-08
公開日2023-03-29
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Nature, 616, 2023
8ET1
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BU of 8et1 by Molmil
CryoEM structure of GSDMB pore without transmembrane beta-barrel
分子名称: Isoform 1 of Gasdermin-B
著者Wang, C, Ruan, J.
登録日2022-10-15
公開日2023-03-29
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.48 Å)
主引用文献Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Nature, 616, 2023
8ET2
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BU of 8et2 by Molmil
CryoEM structure of the GSDMB pore
分子名称: Isoform 1 of Gasdermin-B
著者Wang, C, Ruan, J.
登録日2022-10-15
公開日2023-03-29
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.96 Å)
主引用文献Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Nature, 616, 2023
7RIT
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BU of 7rit by Molmil
Drug-free A. baumannii MsbA
分子名称: ATP-dependent lipid A-core flippase
著者Thelot, F, Liao, M.
登録日2021-07-20
公開日2021-10-06
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
1OZ1
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BU of 1oz1 by Molmil
P38 MITOGEN-ACTIVATED KINASE IN COMPLEX WITH 4-AZAINDOLE INHIBITOR
分子名称: 3-(4-FLUOROPHENYL)-2-PYRIDIN-4-YL-1H-PYRROLO[3,2-B]PYRIDIN-1-OL, Mitogen-activated protein kinase 14
著者Lovejoy, B, Villasenor, A, Browner, M, Dunten, P.
登録日2003-04-07
公開日2003-09-23
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Design and synthesis of 4-azaindoles as inhibitors of p38 MAP kinase.
J.Med.Chem., 46, 2003
5HIC
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BU of 5hic by Molmil
EGFR kinase domain mutant "TMLR" with a imidazopyridinyl-aminopyrimidine inhibitor
分子名称: Epidermal growth factor receptor, N-{2-[1-(cyclopropylsulfonyl)-1H-pyrazol-4-yl]pyrimidin-4-yl}-1-(propan-2-yl)-1H-imidazo[4,5-c]pyridin-6-amine, SULFATE ION
著者Eigenbrot, C, Yu, C.
登録日2016-01-11
公開日2016-04-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Activation Mechanism of Oncogenic Deletion Mutations in BRAF, EGFR, and HER2.
Cancer Cell, 29, 2016
8DGT
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BU of 8dgt by Molmil
Cryo-EM structure of a RAS/RAF complex (state 2)
分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
著者Eck, M.J, Jeon, H, Park, E, Rawson, S.
登録日2022-06-24
公開日2023-07-05
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
8DGS
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BU of 8dgs by Molmil
Cryo-EM structure of a RAS/RAF complex (state 1)
分子名称: 14-3-3 protein zeta, 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, ...
著者Eck, M.J, Jeon, H, Park, E, Rawson, S.
登録日2022-06-24
公開日2023-07-05
最終更新日2023-08-09
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Cryo-EM structure of a RAS/RAF recruitment complex.
Nat Commun, 14, 2023
8DWI
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BU of 8dwi by Molmil
Molecular Mechanism of Sialic Acid Transport Mediated by Sialin
分子名称: Sialin
著者Hu, W, Zheng, H.
登録日2022-08-01
公開日2023-01-25
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献The molecular mechanism of sialic acid transport mediated by Sialin.
Sci Adv, 9, 2023
8ECM
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BU of 8ecm by Molmil
Crystal Structure Analysis of Acetyl-CoA acetyltransferase from Firmicutes bacterium
分子名称: Acetyl-CoA acetyltransferase
著者Seo, H.S, Dhe-Paganon, S.
登録日2022-09-02
公開日2023-05-31
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
Nat Med, 29, 2023

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