5VCS
 
 | | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase with Bound Acceptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, ... | | 著者 | Sanders, J.H, Kadirvelraj, R, Wood, Z.A. | | 登録日 | 2017-03-31 | | 公開日 | 2018-04-11 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.799 Å) | | 主引用文献 | HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5VR8
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5VCR
 | | Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase with bound uranium dioxide | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase, CHLORIDE ION, ... | | 著者 | Sanders, J.H, Kadirvelraj, R, Wood, Z.A. | | 登録日 | 2017-03-31 | | 公開日 | 2018-04-11 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | | 主引用文献 | HumanN-acetylglucosaminyltransferase II substrate recognition uses a modular architecture that includes a convergent exosite.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1XP8
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7X7N
 | | 3D model of the 3-RBD up single trimeric spike protein of SARS-CoV2 in the presence of synthetic peptide SIH-5. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, Synthetic peptide SIH-5 | | 著者 | Khatri, B, Pramanick, I, Malladi, S.K, Rajmani, R.S, Kumar, S, Ghosh, P, Sengupta, N, Rahisuddin, R, Kumaran, S, Ringe, R.P, Varadarajan, R, Dutta, S, Chatterjee, J. | | 登録日 | 2022-03-10 | | 公開日 | 2022-04-27 | | 最終更新日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (4.47 Å) | | 主引用文献 | A dimeric proteomimetic prevents SARS-CoV-2 infection by dimerizing the spike protein.
Nat.Chem.Biol., 18, 2022
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1D5H
 | | Rnase s(f8a). mutant ribonucleasE S. | | 分子名称: | RNASE S, S PEPTIDE, SULFATE ION | | 著者 | Ratnaparkhi, G.S, Varadarajan, R. | | 登録日 | 1999-10-07 | | 公開日 | 1999-10-20 | | 最終更新日 | 2018-03-14 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Thermodynamic and structural studies of cavity formation in proteins suggest that loss of packing interactions rather than the hydrophobic effect dominates the observed energetics.
Biochemistry, 39, 2000
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1D5D
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1FEV
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6Q6F
 | | Crystal structure of IDH1 R132H in complex with HMS101 | | 分子名称: | (2~{R})-2-[2-[(3~{R})-3-(4-fluorophenyl)pyrrolidin-1-yl]ethyl]-1,4-dimethyl-piperazine, Isocitrate dehydrogenase [NADP] cytoplasmic | | 著者 | Chaturvedi, A, Goparaju, R, Gupta, C, Kluenemann, T, Araujo Cruz, M.M, Kloos, A, Goerlich, K, Schottmann, R, Struys, E.A, Ganser, A, Preller, M, Heuser, M. | | 登録日 | 2018-12-10 | | 公開日 | 2019-10-16 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.
Leukemia, 34, 2020
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2RLN
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1NKG
 | | Rhamnogalacturonan lyase from Aspergillus aculeatus | | 分子名称: | CALCIUM ION, Rhamnogalacturonase B, SULFATE ION | | 著者 | McDonough, M.A, Kadirvelraj, R, Harris, P, Poulsen, J.C, Larsen, S. | | 登録日 | 2003-01-03 | | 公開日 | 2004-05-25 | | 最終更新日 | 2018-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Rhamnogalacturonan lyase reveals a unique three-domain modular structure for polysaccharide lyase family 4.
Febs Lett., 565, 2004
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1KEB
 | | Crystal Structure of Double Mutant M37L,P40S E.coli Thioredoxin | | 分子名称: | COPPER (II) ION, Thioredoxin 1 | | 著者 | Rudresh, Jain, R, Dani, V, Mitra, A, Srivastava, S, Sarma, S.P, Varadarajan, R, Ramakumar, S. | | 登録日 | 2001-11-15 | | 公開日 | 2002-11-13 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural Consequences of Replacement of an alpha-helical Pro Residue in E.coli Thioredoxin
PROTEIN ENG., 15, 2002
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1D5E
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1SGU
 | | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease | | 分子名称: | N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE, POL polyprotein | | 著者 | Clemente, J.C, Moose, R.E, Hemrajani, R, Govindasamy, L, Reutzel, R, Mckenna, R, Abandje-McKenna, M, Goodenow, M.M, Dunn, B.M. | | 登録日 | 2004-02-24 | | 公開日 | 2004-10-05 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease.
Biochemistry, 43, 2004
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1SH9
 | | Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease | | 分子名称: | POL polyprotein, RITONAVIR | | 著者 | Clemente, J.C, Moose, R.E, Hemrajani, R, Govindasamy, L, Reutzel, R, McKenna, R, Abanje-McKenna, M, Goodenow, M.M, Dunn, B.M. | | 登録日 | 2004-02-25 | | 公開日 | 2004-10-05 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease.
Biochemistry, 43, 2004
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6OID
 | | Redox Regulation of FN3K from Arabidopsis thaliana | | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... | | 著者 | Wood, Z.A, Kadirvelraj, R, Shrestha, S. | | 登録日 | 2019-04-09 | | 公開日 | 2020-05-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.365 Å) | | 主引用文献 | A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily.
Sci.Signal., 13, 2020
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5WHW
 | | Using sound pulses to solve the crystal harvesting bottleneck | | 分子名称: | 1,2-ETHANEDIOL, BICINE, CALCIUM ION, ... | | 著者 | Soares, A.S, Brennan, H.M, Natarajan, R, McCarthy, L, Leroy, L. | | 登録日 | 2017-07-18 | | 公開日 | 2017-08-02 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Using sound pulses to solve the crystal-harvesting bottleneck.
Acta Crystallogr D Struct Biol, 74, 2018
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5KQF
 | | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine (compound 12) bound to BACE1 | | 分子名称: | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-4-methyl-6-pyrimidin-5-yl-5,6-dihydro-1,3-thiazin-2-amine, Beta-secretase 1 | | 著者 | Lewis, H.A, Wu, Y.J, Rajamani, R, Thompson, L.A. | | 登録日 | 2016-07-06 | | 公開日 | 2016-09-07 | | 最終更新日 | 2016-10-05 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine beta-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.
J.Med.Chem., 59, 2016
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5KR8
 | | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine (compound 5) bound to BACE1 | | 分子名称: | (4~{S},6~{S})-4-[2,4-bis(fluoranyl)phenyl]-6-(3,5-dimethyl-1,2-oxazol-4-yl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, Beta-secretase 1, IODIDE ION | | 著者 | Lewis, H.A, Wu, Y.J, Rajamani, R, Thompson, L.A. | | 登録日 | 2016-07-07 | | 公開日 | 2016-09-07 | | 最終更新日 | 2016-10-05 | | 実験手法 | X-RAY DIFFRACTION (2.118 Å) | | 主引用文献 | Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine beta-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors.
J.Med.Chem., 59, 2016
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7EPG
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7EPI
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7EPJ
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3CWG
 | | Unphosphorylated mouse STAT3 core fragment | | 分子名称: | Signal transducer and activator of transcription 3 | | 著者 | Ren, Z, Mao, X, Mertens, C, Krishnaraj, R, Qin, J, Mandal, P.K, Romanowshi, M.J, McMurray, J.S. | | 登録日 | 2008-04-21 | | 公開日 | 2008-07-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Crystal structure of unphosphorylated STAT3 core fragment.
Biochem.Biophys.Res.Commun., 374, 2008
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1J80
 | | Osmolyte Stabilization of RNase | | 分子名称: | RIBONUCLEASE PANCREATIC, SULFATE ION | | 著者 | Ratnaparkhi, G.S, Varadarajan, R. | | 登録日 | 2001-05-19 | | 公開日 | 2001-06-06 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states.
J.Biol.Chem., 276, 2001
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1J82
 | | Osmolyte Stabilization of RNase | | 分子名称: | RIBONUCLEASE PANCREATIC, SULFATE ION | | 著者 | Ratnaparkhi, G.S, Varadarajan, R. | | 登録日 | 2001-05-19 | | 公開日 | 2001-06-06 | | 最終更新日 | 2017-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Osmolytes stabilize ribonuclease S by stabilizing its fragments S protein and S peptide to compact folding-competent states.
J.Biol.Chem., 276, 2001
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