1SGU
Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
Summary for 1SGU
Entry DOI | 10.2210/pdb1sgu/pdb |
Related | 1SH9 |
Descriptor | POL polyprotein, N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE (3 entities in total) |
Functional Keywords | active site mutations, non-active site mutations, indinavir, hiv-1 protease, hydrolase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22285.22 |
Authors | Clemente, J.C.,Moose, R.E.,Hemrajani, R.,Govindasamy, L.,Reutzel, R.,Mckenna, R.,Abandje-McKenna, M.,Goodenow, M.M.,Dunn, B.M. (deposition date: 2004-02-24, release date: 2004-10-05, Last modification date: 2024-02-14) |
Primary citation | Clemente, J.C.,Moose, R.E.,Hemrajani, R.,Whitford, L.R.,Govindasamy, L.,Reutzel, R.,McKenna, R.,Agbandje-McKenna, M.,Goodenow, M.M.,Dunn, B.M. Comparing the Accumulation of Active- and Nonactive-Site Mutations in the HIV-1 Protease. Biochemistry, 43:12141-12151, 2004 Cited by PubMed: 15379553DOI: 10.1021/bi049459m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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