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1SGU

Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BPOL polyproteinpolymer9910835.72UniProt (P03367)
Pfam (PF00077)
In PDB
Human immunodeficiency virus 1Retropepsin
2BN-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDEnon-polymer613.81Chemie (MK1)
3waterwater18.095Chemie (HOH)
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
PDBExternal DatabaseDetails
Arg 20Lys 88engineered mutation
Ile 32Val 100engineered mutation
Phe 33Leu 101engineered mutation
Ile 36Met 104engineered mutation
Val 54Ile 122engineered mutation
Pro 63Leu 131engineered mutation
Val 71Ala 139engineered mutation
Ala 82Val 150engineered mutation
Val 84Ile 152engineered mutation
Met 90Leu 158engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight21671.4
Non-Polymers*Number of molecules1
Total formula weight613.8
All*Total formula weight22285.2
*Water molecules are not included.

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PDB entries from 2024-09-18

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