1SGU
Comparing the Accumulation of Active Site and Non-active Site Mutations in the HIV-1 Protease
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | POL polyprotein | polymer | 99 | 10835.7 | 2 | UniProt (P03367) Pfam (PF00077) | Human immunodeficiency virus 1 | Retropepsin |
| 2 | C (B) | N-[2(R)-HYDROXY-1(S)-INDANYL]-5-[(2(S)-TERTIARY BUTYLAMINOCARBONYL)-4(3-PYRIDYLMETHYL)PIPERAZINO]-4(S)-HYDROXY-2(R)-PHENYLMETHYLPENTANAMIDE | non-polymer | 613.8 | 1 | Chemie (MK1) PubChem (3706) PubChem (60959) PubChem (5742636) PubChem (9830401) PubChem (9830402) PubChem (12087375) PubChem (15297462) PubChem (23351649) PubChem (23351650) PubChem (45357136) PubChem (46930980) PubChem (3033831) PubChem (53713043) PubChem (58611802) PubChem (58648987) PubChem (59968716) PubChem (60944) PubChem (73265189) PubChem (92758843) PubChem (5362440) PubChem (53713044) PubChem (121366818) PubChem (124932813) PubChem (131632872) PubChem (134462109) PubChem (146347456) PubChem (59096995) PubChem (59913783) PubChem (69890555) PubChem (70259941) PubChem (92758844) PubChem (124932812) PubChem (124932814) PubChem (134693149) PubChem (135081786) PubChem (141832585) PubChem (165707142) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 95 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Arg 20 | Lys 88 | engineered mutation |
| Ile 32 | Val 100 | engineered mutation |
| Phe 33 | Leu 101 | engineered mutation |
| Ile 36 | Met 104 | engineered mutation |
| Val 54 | Ile 122 | engineered mutation |
| Pro 63 | Leu 131 | engineered mutation |
| Val 71 | Ala 139 | engineered mutation |
| Ala 82 | Val 150 | engineered mutation |
| Val 84 | Ile 152 | engineered mutation |
| Met 90 | Leu 158 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 21671.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 613.8 | |
| All* | Total formula weight | 22285.2 |
