8TZG
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![BU of 8tzg by Molmil](/molmil-images/mine/8tzg) | Structure of C-terminal LRRK2 bound to MLi-2 (I2020T mutant) | 分子名称: | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ... | 著者 | Sanz-Murillo, M, Villagran-Suarez, A, Alegrio Louro, J, Leschziner, A. | 登録日 | 2023-08-26 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
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8TXZ
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![BU of 8txz by Molmil](/molmil-images/mine/8txz) | Structure of C-terminal LRRK2 bound to MLi-2 | 分子名称: | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Sanz-Murillo, M, Villagran-Suarez, A, Alegrio-Louro, J, Leschziner, A. | 登録日 | 2023-08-24 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
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6ZS2
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![BU of 6zs2 by Molmil](/molmil-images/mine/6zs2) | Crystal Structure of the bromodomain of human transcription activator BRG1 (SMARCA4) in complex with 2-(6-amino-5-(piperazin-1-yl)pyridazin-3-yl)phenol | 分子名称: | 1,2-ETHANEDIOL, 2-(6-azanyl-5-piperazin-4-ium-1-yl-pyridazin-3-yl)phenol, Transcription activator BRG1 | 著者 | Preuss, F, Joerger, A.C, Kraemer, A, Wanior, M, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2020-07-15 | 公開日 | 2020-10-07 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J.Med.Chem., 63, 2020
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8TZE
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![BU of 8tze by Molmil](/molmil-images/mine/8tze) | Structure of C-terminal half of LRRK2 bound to GZD-824 | 分子名称: | 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide, Leucine-rich repeat serine/threonine-protein kinase 2 | 著者 | Villagran-Suarez, A, Sanz-Murillo, M, Alegrio-Louro, J, Leschziner, A. | 登録日 | 2023-08-26 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
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8TZH
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![BU of 8tzh by Molmil](/molmil-images/mine/8tzh) | Structure of full-length LRRK2 bound to MLi-2 (I2020T mutant) | 分子名称: | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, E11 DARPin, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Sanz-Murillo, M, Villagran-Suarez, A, Alegrio Louro, J, Leschziner, A. | 登録日 | 2023-08-26 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
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8TZF
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![BU of 8tzf by Molmil](/molmil-images/mine/8tzf) | Structure of full length LRRK2 bound to GZD-824 (I2020T mutant) | 分子名称: | 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, Leucine-rich repeat serine/threonine-protein kinase 2, ... | 著者 | Villagran-Suarez, A, Sanz-Murillo, M, Alegrio-Louro, J, Leschziner, A. | 登録日 | 2023-08-26 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
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8TZC
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![BU of 8tzc by Molmil](/molmil-images/mine/8tzc) | Structure of C-terminal LRRK2 bound to MLi-2 (G2019S mutant) | 分子名称: | (2~{R},6~{S})-2,6-dimethyl-4-[6-[5-(1-methylcyclopropyl)oxy-1~{H}-indazol-3-yl]pyrimidin-4-yl]morpholine, E11 DARPin, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Sanz-Murillo, M, Villagran-Suarez, A, Alegrio-Louro, J, Leschziner, A. | 登録日 | 2023-08-26 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
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8TZB
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![BU of 8tzb by Molmil](/molmil-images/mine/8tzb) | Structure of the C-terminal half of LRRK2 bound to GZD-824 (I2020T mutant) | 分子名称: | 4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-[(1H-pyrazolo[3,4-b]pyridin-5-yl)ethynyl]benzamide, Leucine-rich repeat serine/threonine-protein kinase 2, designed ankyrin repeat proteins E11 | 著者 | Villagran-Suarez, A, Sanz-Murillo, M, Alegrio-Louro, J, Leschziner, A. | 登録日 | 2023-08-26 | 公開日 | 2023-12-06 | 最終更新日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Inhibition of Parkinson's disease-related LRRK2 by type I and type II kinase inhibitors: Activity and structures. Sci Adv, 9, 2023
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6GIP
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![BU of 6gip by Molmil](/molmil-images/mine/6gip) | Crystal structure of the ACVR1 (ALK2) kinase in complex with a Quinazolinone based ALK2 inhibitor with a 2, 5-dimethyl core. | 分子名称: | 1,2-ETHANEDIOL, 2,5-dimethyl-6-quinolin-4-yl-3~{H}-quinazolin-4-one, Activin receptor type-1, ... | 著者 | Williams, E, Hudson, L, Bezerra, G.A, Sorrell, F, Mathea, S, Chen, Z, Mahajan, P, Kupinska, K, Hoelder, S, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. | 登録日 | 2018-05-14 | 公開日 | 2018-05-23 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Novel Quinazolinone Inhibitors of ALK2 Flip between Alternate Binding Modes: Structure-Activity Relationship, Structural Characterization, Kinase Profiling, and Cellular Proof of Concept. J. Med. Chem., 61, 2018
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5L6W
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![BU of 5l6w by Molmil](/molmil-images/mine/5l6w) | Structure Of the LIMK1-ATPgammaS-CFL1 Complex | 分子名称: | Cofilin-1, LIM domain kinase 1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Salah, E, Mathea, S, Oerum, S, Newman, J.A, Tallant, C, Adamson, R, Canning, P, Beltrami, A, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S, Bullock, A.N. | 登録日 | 2016-05-31 | 公開日 | 2016-06-08 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.53 Å) | 主引用文献 | Structure Of the LIMK1-ATPgammaS-CFL1 Complex To Be Published
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5O1O
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![BU of 5o1o by Molmil](/molmil-images/mine/5o1o) | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with proline bound. | 分子名称: | 1,2-ETHANEDIOL, Alpha-aminoadipic semialdehyde synthase, mitochondrial, ... | 著者 | Kopec, J, Rembeza, E, Pena, I.A, Mathea, S, Velupillai, S, Strain-Damerell, C, Goubin, S, Kupinska, K, Talon, R, Collins, P, Krojer, T, Burgess-Brown, N, Arrowsmith, C, Edwards, A, Bountra, C, von Delft, F, Arruda, P, Yue, W.W. | 登録日 | 2017-05-18 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with proline bound. To Be Published
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6GY5
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![BU of 6gy5 by Molmil](/molmil-images/mine/6gy5) | Crystal structure of the kelch domain of human KLHL20 in complex with DAPK1 peptide | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, Death-associated protein kinase 1, ... | 著者 | Chen, Z, Hozjan, V, Strain-Damerell, C, Williams, E, Wang, D, Cooper, C.D.O, Sanvitale, C.E, Fairhead, M, Carpenter, E.P, Pike, A.C.W, Krojer, T, Srikannathasan, V, Sorrell, F, Johansson, C, Mathea, S, Burgess-Brown, N, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Bullock, A.N. | 登録日 | 2018-06-28 | 公開日 | 2018-08-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.086 Å) | 主引用文献 | Structural Basis for Recruitment of DAPK1 to the KLHL20 E3 Ligase. Structure, 27, 2019
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5T3P
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![BU of 5t3p by Molmil](/molmil-images/mine/5t3p) | Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7 | 分子名称: | 1,2-ETHANEDIOL, Peroxisomal coenzyme A diphosphatase NUDT7 | 著者 | Srikannathasan, V, Nunez, C.A, Tallant, C, Siejka, P, Mathea, S, Kopec, J, Elkins, J.M, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Huber, K. | 登録日 | 2016-08-26 | 公開日 | 2017-09-13 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Crystal structure of Human Peroxisomal coenzyme A diphosphatase NUDT7 To Be Published
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5LTU
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![BU of 5ltu by Molmil](/molmil-images/mine/5ltu) | Crystal Structure of NUDT4A- Diphosphoinositol polyphosphate phosphohydrolase 2 | 分子名称: | 1,2-ETHANEDIOL, Diphosphoinositol polyphosphate phosphohydrolase 2 | 著者 | Srikannathasan, V, Nunez, C.A, Tallant, C, Siejka, P, Mathea, S, Newman, J, Strain-Damerell, C, Elkins, J.M, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, von Delft, F, Huber, K. | 登録日 | 2016-09-07 | 公開日 | 2017-09-20 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Crystal Structure of Human NUDT4A- Diphosphoinositol polyphosphate phosphohydrolase 2 To Be Published
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