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X-ray Structure of Omwaprin
分子名称:	Omwaprin-a
著者	Banigan, J.R, Mandal, K, Sawaya, M.R, Thammavongsa, V, Hendrickx, A.P.A, Schneewind, O, Yeates, T.O, Kent, S.B.H.
登録日	2010-06-11
公開日	2010-09-08
最終更新日	2011-07-13
実験手法	X-RAY DIFFRACTION (1.33 Å)
主引用文献	Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography. Protein Sci., 19, 2010

3NWQ

X-ray structure of ester chemical analogue [O-Ile50,O-Ile50']HIV-1 protease complexed with MVT-101
分子名称:	N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, protease
著者	Torbeev, V.Y, Kent, S.B.H.
登録日	2010-07-10
公開日	2011-11-02
最終更新日	2018-01-24
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011

3HLO

Crystal structure of chemically synthesized 'covalent dimer' [Gly51/D-Ala51']HIV-1 protease
分子名称:	'covalent dimer' [Gly51/D-Ala51'] HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
著者	Torbeev, V.Y, Kent, S.B.H.
登録日	2009-05-27
公開日	2011-07-27
最終更新日	2012-12-12
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011

3NXE

X-ray structure of ester chemical analogue 'covalent dimer' [Ile50,O-Ile50']HIV-1 protease complexed with MVT-101 inhibitor
分子名称:	N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, protease covalent dimer
著者	Torbeev, V.Y, Kent, S.B.H.
登録日	2010-07-13
公開日	2011-11-02
最終更新日	2012-12-12
実験手法	X-RAY DIFFRACTION (1.61 Å)
主引用文献	Protein conformational dynamics in the mechanism of HIV-1 protease catalysis. Proc.Natl.Acad.Sci.USA, 108, 2011

2E3W

X-ray structure of native RNase A
分子名称:	CHLORIDE ION, Ribonuclease pancreatic
著者	Boerema, D.J, Tereshko, V.A, Kent, S.B.H.
登録日	2006-11-30
公開日	2007-10-30
最終更新日	2023-08-23
実験手法	X-RAY DIFFRACTION (1.05 Å)
主引用文献	Total synthesis by modern chemical ligation methods and high resolution (1.1 A) X-ray structure of ribonuclease A Biopolymers, 90, 2008

5UDP

High resolution x-ray crystal structure of synthetic insulin lispro
分子名称:	CHLORIDE ION, Insulin Lispro A chain, Insulin Lispro B chain, ...
著者	Mandal, K, Dhayalan, B, Kent, S.B.H.
登録日	2016-12-28
公開日	2017-01-11
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (1.348 Å)
主引用文献	Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin. Chemistry, 23, 2017

2NUI

X-ray Structure of synthetic [D83A]RNase A
分子名称:	2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, Ribonuclease pancreatic
著者	Boerema, D.J, Tereshko, V.A, Kent, S.B.H.
登録日	2006-11-09
公開日	2007-10-30
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.1 Å)
主引用文献	Total synthesis by modern chemical ligation methods and high resolution (1.1 A) X-ray structure of ribonuclease A Biopolymers, 90, 2008

2O40

Crystal Structure of a Chemically Synthesized 203 Amino Acid 'Covalent Dimer' HIV-1 Protease Molecule
分子名称:	N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, covalent dimer HIV-1 protease
著者	Torbeev, V.Y, Kent, S.B.H.
登録日	2006-12-02
公開日	2006-12-19
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Convergent chemical synthesis and crystal structure of a 203 amino acid "covalent dimer" HIV-1 protease enzyme molecule. Angew.Chem.Int.Ed.Engl., 46, 2007

2NWD

Structure of chemically synthesized human lysozyme at 1 Angstrom resolution
分子名称:	Lysozyme C
著者	Durek, T, Torbeev, V.Y, Kent, S.B.H.
登録日	2006-11-14
公開日	2006-12-19
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (1.04 Å)
主引用文献	Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme. Proc.Natl.Acad.Sci.Usa, 104, 2007

2PNE

Crystal Structure of the Snow Flea Antifreeze Protein
分子名称:	6.5 kDa glycine-rich antifreeze protein
著者	Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M.
登録日	2007-04-24
公開日	2008-04-29
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (0.98 Å)
主引用文献	X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers J.Am.Chem.Soc., 130, 2008

7LL8

D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A
分子名称:	Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V1
著者	Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S.
登録日	2021-02-03
公開日	2021-02-17
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.31 Å)
主引用文献	A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth. Acs Chem.Biol., 16, 2021

7LL9

D-Protein RFX-V2 Bound to the VEGFR1 Domain 3 Site on VEGF-A
分子名称:	Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V2
著者	Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S.
登録日	2021-02-03
公開日	2021-03-03
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth. Acs Chem.Biol., 16, 2021

3DCK

X-ray structure of D25N chemical analogue of HIV-1 protease complexed with ketomethylene isostere inhibitor
分子名称:	(2S)-2-{[(2R,5S)-5-{[(2S,3S)-2-{[(2S,3R)-2-(acetylamino)-3-hydroxybutanoyl]amino}-3-methylpentanoyl]amino}-2-butyl-4-oxononanoyl]amino}-N~1~-[(2S)-1-amino-5-carbamimidamido-1-oxopentan-2-yl]pentanediamide, Chemical analogue HIV-1 protease
著者	Torbeev, V.Y, Mandal, K, Terechko, V.A, Kent, S.B.H.
登録日	2008-06-03
公開日	2008-08-19
最終更新日	2024-03-20
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site Bioorg.Med.Chem.Lett., 18, 2008

3DCR

X-ray structure of HIV-1 protease and hydrated form of ketomethylene isostere inhibitor
分子名称:	Chemical analogue HIV-1 protease, N~2~-[(2R,5S)-5-({(2S,3S)-2-[(N-acetyl-L-threonyl)amino]-3-methylpent-4-enoyl}amino)-2-butyl-4,4-dihydroxynonanoyl]-L-glutaminyl-L-argininamide
著者	Torbeev, V.Y, Mandal, K, Terechko, V.A, Kent, S.B.H.
登録日	2008-06-04
公開日	2008-08-19
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.4 Å)
主引用文献	Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site Bioorg.Med.Chem.Lett., 18, 2008

3GI0

Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [l-ala51,d-ala51'] hiv-1 protease molecule complexed with jg-365 inhibitor
分子名称:	COVALENT DIMER [L-ALA51,D-ALA51'] HIV-1 PROTEASE, JG-365 inhibitor
著者	Torbeev, V.Y, Kent, S.B.H.
登録日	2009-03-04
公開日	2011-08-10
最終更新日	2023-11-15
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Correlations of protein dynamics with function in HIV-1 protease catalysis To be Published

3I2L

Crystal structure of a chemically synthesized [allo-Ile50/50']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor
分子名称:	HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide
著者	Torbeev, V.Y, Kent, S.B.H.
登録日	2009-06-29
公開日	2011-04-27
最終更新日	2014-02-12
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Hydrogen bonds at the protein-inhibitor interface in the HIV-1 protease / inhibitors complexes probed by total chemical synthesis and X-ray crystallography To be Published

3HZC

Crystal structure of a chemically synthesized 203 amino acid 'covalent dimer' [Gly51;Aib51']HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor
分子名称:	N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, [Gly51;Aib51'] 'covalent dimer' HIV-1 protease
著者	Torbeev, V.Y, Kent, S.B.H.
登録日	2009-06-23
公開日	2011-04-27
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.45 Å)
主引用文献	Hydrogen bonds at the protein-inhibitor interface in the HIV-1 protease / inhibitors complexes probed by total chemical synthesis and X-ray crystallography To be Published

3IA9

Crystal structure of a chemically synthesized [D25N]HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor
分子名称:	N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, [D25N]HIV-1 protease
著者	Torbeev, V.Y, Kent, S.B.H.
登録日	2009-07-13
公開日	2011-07-27
最終更新日	2012-12-12
実験手法	X-RAY DIFFRACTION (1.3 Å)
主引用文献	Hydrogen bonds at the protein-inhibitor interface in the HIV-1 protease / inhibitors complexes probed by total chemical synthesis and X-ray crystallography To be Published

2OQF

Structure of a synthetic, non-natural analogue of RNase A: [N71K(Ade), D83A]RNase A
分子名称:	Ribonuclease pancreatic
著者	Boerema, D.J, Tereshko, V.A, Zhang, J.L, He, C, Kent, S.B.H.
登録日	2007-01-31
公開日	2008-02-12
最終更新日	2023-08-30
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Design, Synthesis, and Characterization of Non-natural RNase A Analogues with Enhanced Second-step Catalytic Activity To be Published

1LPV

DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES
分子名称:	Doublesex protein, ZINC ION
著者	Zhu, L, Wilken, J, Phillips, N, Narendra, U, Chan, G, Stratton, S, Kent, S, Weiss, M.A.
登録日	2002-05-08
公開日	2002-10-02
最終更新日	2024-05-22
実験手法	SOLUTION NMR
主引用文献	Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers. Genes Dev., 14, 2000

3HVP

CONSERVED FOLDING IN RETROVIRAL PROTEASES. CRYSTAL STRUCTURE OF A SYNTHETIC HIV-1 PROTEASE
分子名称:	UNLIGANDED HIV-1 PROTEASE
著者	Wlodawer, A, Jaskolski, M, Miller, M.
登録日	1989-08-08
公開日	1989-10-15
最終更新日	2017-11-29
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Conserved folding in retroviral proteases: crystal structure of a synthetic HIV-1 protease. Science, 245, 1989

2JE4

Atomic-resolution crystal structure of chemically-synthesized HIV-1 protease in complex with JG-365
分子名称:	ACETATE ION, GLYCEROL, INHIBITOR MOLECULE JG365, ...
著者	Malito, E, Johnson, E.C.B, Tang, W.J.
登録日	2007-01-15
公開日	2007-08-28
最終更新日	2023-12-13
実験手法	X-RAY DIFFRACTION (1.07 Å)
主引用文献	Modular Total Chemical Synthesis of a Human Immunodeficiency Virus Type 1 Protease. J.Am.Chem.Soc., 129, 2007

7BGU

Mason-Pfizer Monkey Virus Protease mutant C7A/D26N/C106A in complex with peptidomimetic inhibitor
分子名称:	Gag-Pro-Pol polyprotein, PENTAETHYLENE GLYCOL, peptidomimetic inhibitor
著者	Wosicki, S, Gilski, M, Kazmierczyk, M, Jaskolski, M, Zabranska, H, Pichova, I.
登録日	2021-01-08
公開日	2021-12-15
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (2.433 Å)
主引用文献	Crystal structures of inhibitor complexes of M-PMV protease with visible flap loops. Protein Sci., 30, 2021

7BGT

Mason-Pfizer Monkey Virus Protease mutant C7A/D26N/C106A in complex with peptidomimetic inhibitor
分子名称:	ACETATE ION, Gag-Pro-Pol polyprotein, PENTAETHYLENE GLYCOL, ...
著者	Wosicki, S, Gilski, M, Jaskolski, M, Zabranska, H, Pichova, I.
登録日	2021-01-08
公開日	2021-12-15
最終更新日	2024-01-31
実験手法	X-RAY DIFFRACTION (1.93 Å)
主引用文献	Crystal structures of inhibitor complexes of M-PMV protease with visible flap loops. Protein Sci., 30, 2021

6S1U

Crystal structure of dimeric M-PMV protease C7A/D26N/C106A mutant in complex with inhibitor
分子名称:	Gag-Pro-Pol polyprotein, PRO-0A1-VAL-PSA-ALA-MET-THR
著者	Wosicki, S, Gilski, M, Jaskolski, M, Zabranska, H, Pichova, I.
登録日	2019-06-19
公開日	2019-10-16
最終更新日	2024-01-24
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Comparison of a retroviral protease in monomeric and dimeric states. Acta Crystallogr D Struct Biol, 75, 2019

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