3IA9

Crystal structure of a chemically synthesized [D25N]HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor

Summary for 3IA9

• Entry DOI: 10.2210/pdb3ia9/pdb
• Related: 3FSM 3HAU 3HAW 3HBO 3HDK 3HLO
• Related PRD ID: PRD_000398
• Descriptor: [D25N]HIV-1 protease, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: beta-sheet, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Total number of polymer chains: 2
• Total formula weight: 22482.39

Authors

Torbeev, V.Y.,Kent, S.B.H. (deposition date: 2009-07-13, release date: 2011-07-27, Last modification date: 2012-12-12)

• Primary citation: Torbeev, V.Y.,Kent, S.B.H.; Hydrogen bonds at the protein-inhibitor interface in the HIV-1 protease / inhibitors complexes probed by total chemical synthesis and X-ray crystallography; To be Published,

Experimental method

X-RAY DIFFRACTION (1.3 Å)