3IA9
Crystal structure of a chemically synthesized [D25N]HIV-1 protease molecule complexed with MVT-101 reduced isostere inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0055036 | cellular_component | virion membrane |
| A | 0072494 | cellular_component | host multivesicular body |
| B | 0004190 | molecular_function | aspartic-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0055036 | cellular_component | virion membrane |
| B | 0072494 | cellular_component | host multivesicular body |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE 2NC A 100 |
| Chain | Residue |
| A | ASN25 |
| A | PHE53 |
| A | VAL82 |
| A | ILE84 |
| A | HOH101 |
| A | HOH107 |
| A | HOH109 |
| A | HOH112 |
| A | HOH118 |
| A | HOH128 |
| A | HOH139 |
| A | GLY27 |
| A | HOH148 |
| B | LEU23 |
| B | ASN25 |
| B | GLY27 |
| B | ALA28 |
| B | ASP29 |
| B | ASP30 |
| B | NLE46 |
| B | ILE47 |
| B | GLY48 |
| A | ALA28 |
| B | GLY49 |
| B | ILE50 |
| B | PHE53 |
| B | PRO81 |
| B | ILE84 |
| B | HOH121 |
| A | ASP29 |
| A | ASP30 |
| A | ILE47 |
| A | GLY48 |
| A | GLY49 |
| A | ILE50 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 401 |
| Chain | Residue |
| A | LEU10 |
| A | GLU21 |
| A | ALA22 |
| A | VAL82 |
| A | ASN83 |
| A | HOH106 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 402 |
| Chain | Residue |
| A | THR12 |
| A | ILE13 |
| A | ARG14 |
| A | LEU19 |
| A | TRP42 |
| A | PRO44 |
| A | GLU65 |
| A | ILE66 |
| A | ABA67 |
| A | GLY68 |
