4N8R
| Crystal structure of RXRa LBD complexed with a synthetic modulator K-8008 | 分子名称: | 5-(2-{(1Z)-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha | 著者 | Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. | 登録日 | 2013-10-17 | 公開日 | 2014-05-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
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4N5G
| Crystal Structure of RXRa LBD complexed with a synthetic modulator K8012 | 分子名称: | 5-(2-{(1Z)-5-fluoro-2-methyl-1-[4-(propan-2-yl)benzylidene]-1H-inden-3-yl}ethyl)-1H-tetrazole, Retinoic acid receptor RXR-alpha | 著者 | Aleshin, A.E, Su, Y, Zhang, X, Liddington, R.C. | 登録日 | 2013-10-09 | 公開日 | 2014-05-14 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | Sulindac-Derived RXR alpha Modulators Inhibit Cancer Cell Growth by Binding to a Novel Site. Chem.Biol., 21, 2014
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5IZ9
| Protein-protein interaction | 分子名称: | ACE-GLY-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | 登録日 | 2016-03-25 | 公開日 | 2017-07-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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1GHD
| Crystal structure of the glutaryl-7-aminocephalosporanic acid acylase by mad phasing | 分子名称: | GLUTARYL-7-AMINOCEPHALOSPORANIC ACID ACYLASE | 著者 | Ding, Y, Jiang, W, Mao, X, He, H, Zhang, S, Tang, H, Bartlam, M, Ye, S, Jiang, F, Liu, Y, Zhao, G, Rao, Z. | 登録日 | 2000-12-07 | 公開日 | 2003-07-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Affinity alkylation of the Trp-B4 residue of the beta -subunit of the glutaryl 7-aminocephalosporanic acid acylase of Pseudomonas sp. 130. J.Biol.Chem., 277, 2002
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4ZZH
| SIRT1/Activator Complex | 分子名称: | (4S)-N-[3-(1,3-oxazol-5-yl)phenyl]-7-[3-(trifluoromethyl)phenyl]-3,4-dihydro-1,4-methanopyrido[2,3-b][1,4]diazepine-5(2H)-carboxamide, NAD-dependent protein deacetylase sirtuin-1, ZINC ION | 著者 | Dai, H. | 登録日 | 2015-05-22 | 公開日 | 2015-07-15 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (3.1001 Å) | 主引用文献 | Crystallographic structure of a small molecule SIRT1 activator-enzyme complex. Nat Commun, 6, 2015
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4ZZJ
| SIRT1/Activator/Substrate Complex | 分子名称: | (3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide, Ac-p53, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Dai, H. | 登録日 | 2015-05-22 | 公開日 | 2015-07-15 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.7403 Å) | 主引用文献 | Crystallographic structure of a small molecule SIRT1 activator-enzyme complex. Nat Commun, 6, 2015
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4ZZI
| SIRT1/Activator/Inhibitor Complex | 分子名称: | (3S)-1,3-dimethyl-N-[3-(1,3-oxazol-5-yl)phenyl]-6-[3-(trifluoromethyl)phenyl]-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide, 4-(4-{2-[(methylsulfonyl)amino]ethyl}piperidin-1-yl)thieno[3,2-d]pyrimidine-6-carboxamide, NAD-dependent protein deacetylase sirtuin-1, ... | 著者 | Dai, H. | 登録日 | 2015-05-22 | 公開日 | 2015-07-15 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.7346 Å) | 主引用文献 | Crystallographic structure of a small molecule SIRT1 activator-enzyme complex. Nat Commun, 6, 2015
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6ZHC
| PROTAC6 mediated complex of VHL:EloB:EloC and Bcl-xL | 分子名称: | 1,2-ETHANEDIOL, 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1~{H}-isoquinolin-2-yl]-5-[3-[4-[3-[2-[2-[2-[2-[2-[3-[[(2~{S})-3,3-dimethyl-1-[(2~{S},4~{R})-2-[[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylcarbamoyl]-4-oxidanyl-pyrrolidin-1-yl]-1-oxidanylidene-butan-2-yl]amino]-3-oxidanylidene-propoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]prop-1-ynyl]phenoxy]propyl]-1,3-thiazole-4-carboxylic acid, Bcl-2-like protein 1, ... | 著者 | Chung, C. | 登録日 | 2020-06-22 | 公開日 | 2020-08-05 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. Acs Chem.Biol., 15, 2020
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7R8V
| Cryo-EM structure of the ADP state actin filament | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Espinosa de los Reyes, S, Reynolds, M.J, Gurel, P, Alushin, G.M. | 登録日 | 2021-06-27 | 公開日 | 2021-07-28 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (2.82 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7R91
| cryo-EM structure of the rigor state wild type myosin-15-F-actin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | 登録日 | 2021-06-28 | 公開日 | 2021-07-28 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7RB9
| Cryo-EM structure of the rigor state Jordan myosin-15-F-actin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | 登録日 | 2021-07-05 | 公開日 | 2021-07-28 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.76 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7RB8
| cryo-EM structure of the ADP state wild type myosin-15-F-actin complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Reynolds, M.J, Gurel, P, Alushin, G.M. | 登録日 | 2021-07-05 | 公開日 | 2021-07-28 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7UDT
| cryo-EM structure of the rigor state wild type myosin-15-F-actin complex (symmetry expansion and re-centering) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Reynolds, M.J, Alushin, G.M. | 登録日 | 2022-03-20 | 公開日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (3.17 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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7UDU
| cryo-EM structure of the ADP state wild type myosin-15-F-actin complex (symmetry expansion and re-centering) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha skeletal muscle, ... | 著者 | Gong, R, Reynolds, M.J, Alushin, G.M. | 登録日 | 2022-03-20 | 公開日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (4.15 Å) | 主引用文献 | Structural basis for tunable control of actin dynamics by myosin-15 in mechanosensory stereocilia. Sci Adv, 8, 2022
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6TXZ
| FAB PART OF M6903 IN COMPLEX WITH HUMAN TIM3 | 分子名称: | Fab H, Fab L, Hepatitis A virus cellular receptor 2 | 著者 | Musil, D, Sood, V. | 登録日 | 2020-01-15 | 公開日 | 2020-04-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Identification and characterization of M6903, an antagonistic anti-TIM-3 monoclonal antibody. Oncoimmunology, 9, 2020
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5TBP
| Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003 | 分子名称: | ACETATE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Aleshin, A.E, Liddington, R.C, Su, Y, Zhang, X. | 登録日 | 2016-09-12 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha. Nat Commun, 8, 2017
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5IZ6
| Protein-protein interaction | 分子名称: | Adenomatous polyposis coli protein, DI(HYDROXYETHYL)ETHER, PHQ-ALA-GLY-GLU-ALA-LEU-TYR-GLU-NH2, ... | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | 登録日 | 2016-03-25 | 公開日 | 2017-07-05 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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5B6G
| Protein-protein interaction | 分子名称: | Adenomatous polyposis coli protein, GLYCEROL, PHQ-ALA-GLY-GLU-ALA-XYC-TYR-GLU, ... | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | 登録日 | 2016-05-27 | 公開日 | 2017-05-31 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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5J3F
| NMR solution structure of [Rp, Rp]-PT dsDNA | 分子名称: | DNA (5'-D(*CP*GP*(RSG)P*CP*CP*GP*CP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*GP*CP*GP*(RSG)P*CP*CP*G)-3') | 著者 | Lan, W, Hu, Z, Cao, C. | 登録日 | 2016-03-30 | 公開日 | 2016-11-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural investigation into physiological DNA phosphorothioate modification Sci Rep, 6, 2016
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5J3G
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5J3I
| NMR solution structure of [Sp, Sp]-PT dsDNA | 分子名称: | DNA (5'-D(*CP*GP*(SSG)P*CP*CP*GP*CP*CP*GP*A)-3'), DNA (5'-D(*TP*CP*GP*GP*CP*GP*(SSG)P*CP*CP*G)-3') | 著者 | Lan, W, Hu, Z, Cao, C. | 登録日 | 2016-03-30 | 公開日 | 2016-11-16 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural investigation into physiological DNA phosphorothioate modification Sci Rep, 6, 2016
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4FVT
| Human SIRT3 bound to Ac-ACS peptide and Carba-NAD | 分子名称: | Acetylated ACS2 peptide, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL, ... | 著者 | Dai, H. | 登録日 | 2012-06-29 | 公開日 | 2012-08-15 | 最終更新日 | 2012-09-19 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5. J.Org.Chem., 77, 2012
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4G1C
| Human SIRT5 bound to Succ-IDH2 and Carba-NAD | 分子名称: | CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NAD-dependent protein deacylase sirtuin-5, mitochondrial, ... | 著者 | Dai, H. | 登録日 | 2012-07-10 | 公開日 | 2012-08-15 | 最終更新日 | 2012-09-19 | 実験手法 | X-RAY DIFFRACTION (1.944 Å) | 主引用文献 | Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5. J.Org.Chem., 77, 2012
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4G1N
| PKM2 in complex with an activator | 分子名称: | MAGNESIUM ION, N-(4-{[4-(pyrazin-2-yl)piperazin-1-yl]carbonyl}phenyl)quinoline-8-sulfonamide, OXALATE ION, ... | 著者 | Kung, C, Hixon, J, Dang, L, DeLaBarre, B, Qian, K.C. | 登録日 | 2012-07-10 | 公開日 | 2012-10-10 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy. Chem.Biol., 19, 2012
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5IZ8
| Protein-protein interaction | 分子名称: | ACE-ALA-GLY-GLU-ALA-LEU-ALA-ASP-NH2, Adenomatous polyposis coli protein, TRIETHYLENE GLYCOL | 著者 | Zhao, Y, Jiang, H, Yang, X, Jiang, F, Song, K, Zhang, J. | 登録日 | 2016-03-25 | 公開日 | 2017-07-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration. Nat. Chem. Biol., 13, 2017
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