4ZZJ

SIRT1/Activator/Substrate Complex

Summary for 4ZZJ

• Entry DOI: 10.2210/pdb4zzj/pdb
• Descriptor: NAD-dependent protein deacetylase sirtuin-1, Ac-p53, ZINC ION, ... (7 entities in total)
• Functional Keywords: sirtuin, activator, deacylase, complex, hydrolase
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus, PML body. SirtT1 75 kDa fragment: Cytoplasm: Q96EB6
• Total number of polymer chains: 2
• Total formula weight: 42517.03

Authors

Dai, H. (deposition date: 2015-05-22, release date: 2015-07-15, Last modification date: 2023-11-15)

• Primary citation: Dai, H.,Case, A.W.,Riera, T.V.,Considine, T.,Lee, J.E.,Hamuro, Y.,Zhao, H.,Jiang, Y.,Sweitzer, S.M.,Pietrak, B.,Schwartz, B.,Blum, C.A.,Disch, J.S.,Caldwell, R.,Szczepankiewicz, B.,Oalmann, C.,Yee Ng, P.,White, B.H.,Casaubon, R.,Narayan, R.,Koppetsch, K.,Bourbonais, F.,Wu, B.,Wang, J.,Qian, D.,Jiang, F.,Mao, C.,Wang, M.,Hu, E.,Wu, J.C.,Perni, R.B.,Vlasuk, G.P.,Ellis, J.L.; Crystallographic structure of a small molecule SIRT1 activator-enzyme complex.; Nat Commun, 6:7645-7645, 2015; PubMed: 26134520; DOI: 10.1038/ncomms8645

Experimental method

X-RAY DIFFRACTION (2.7403 Å)