4ZZJ
SIRT1/Activator/Substrate Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 701 |
| Chain | Residue |
| A | CYS371 |
| A | CYS374 |
| A | CYS395 |
| A | CYS398 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | binding site for residue CNA A 702 |
| Chain | Residue |
| A | PRO271 |
| A | ASP272 |
| A | PHE273 |
| A | ARG274 |
| A | PHE297 |
| A | ILE316 |
| A | GLN345 |
| A | ASN346 |
| A | ILE347 |
| A | ASP348 |
| A | GLY440 |
| A | SER441 |
| A | SER442 |
| A | ASN465 |
| A | ARG466 |
| A | GLU467 |
| A | GLY480 |
| A | ASP481 |
| A | CYS482 |
| A | HOH809 |
| A | HOH813 |
| B | ALY4 |
| A | GLY261 |
| A | ALA262 |
| A | GLY263 |
| A | VAL266 |
| A | ILE270 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue 4TQ A 703 |
| Chain | Residue |
| A | LEU206 |
| A | LEU206 |
| A | THR209 |
| A | THR209 |
| A | PRO211 |
| A | PRO212 |
| A | GLN222 |
| A | ILE223 |
| A | ASN226 |
| A | ILE227 |
| A | GLU230 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 704 |
| Chain | Residue |
| A | VAL353 |
| A | ALA382 |
| A | VAL383 |
| A | ASP386 |
| A | PRO396 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL A 705 |
| Chain | Residue |
| A | PHE422 |
| A | HIS423 |
| A | LEU450 |
| A | SER454 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | Domain: {"description":"Deacetylase sirtuin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Region: {"description":"Required for interaction with the sumoylated form of CCAR2","evidences":[{"source":"PubMed","id":"25406032","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Motif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Motif: {"description":"Nuclear export signal","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11672523","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12006491","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12535671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17290224","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18004385","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18235501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18485871","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19934257","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25406032","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28497810","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"38512451","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8IXJ6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00236","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by CaMK2","evidences":[{"source":"UniProtKB","id":"Q923E4","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"29474172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
