8I9Y
| Cryo-EM structure of a Chaetomium thermophilum pre-60S ribosomal subunit - Ytm1-2 | 分子名称: | 60S ribosomal protein L12-like protein, 60S ribosomal protein L13, 60S ribosomal protein L14-like protein, ... | 著者 | Lau, B, Huang, Z, Beckmann, R, Hurt, E, Cheng, J. | 登録日 | 2023-02-07 | 公開日 | 2023-05-17 | 最終更新日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Mechanism of 5S RNP recruitment and helicase-surveilled rRNA maturation during pre-60S biogenesis. Embo Rep., 24, 2023
|
|
3WVJ
| The crystal structure of native glycosidic hydrolase | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-glucanase | 著者 | Chen, C.C, Huang, J.W, Zhao, P, Ko, T.P, Huang, C.H, Chan, H.C, Huang, Z, Liu, W, Cheng, Y.S, Liu, J.R, Guo, R.T. | 登録日 | 2014-05-22 | 公開日 | 2015-06-24 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural analyses and yeast production of the beta-1,3-1,4-glucanase catalytic module encoded by the licB gene of Clostridium thermocellum. Enzyme.Microb.Technol., 71, 2015
|
|
5USG
| 5-Se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | 分子名称: | DNA (5'-D(*AP*(T5S)P*GP*(T5S)P*CP*G)-3'), MAGNESIUM ION, RNA (5'-R(*UP*CP*GP*AP*CP*A)-3'), ... | 著者 | Fang, Z, Qin, L, Huang, Z. | 登録日 | 2017-02-13 | 公開日 | 2017-03-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate Chemistryselect, 8, 2023
|
|
5US2
| |
5USA
| 5-Se-T2-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | 分子名称: | DNA (5'-D(*AP*(T5S)P*GP*TP*CP*G)-3'), MAGNESIUM ION, RNA (5'-R(*UP*CP*GP*AP*CP*A)-3'), ... | 著者 | Fang, Z, Qin, L, Huang, Z. | 登録日 | 2017-02-13 | 公開日 | 2017-03-08 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate Chemistryselect, 8, 2023
|
|
5USE
| 5-Se-T4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | 分子名称: | DNA (5'-D(*AP*TP*GP*(T5S)P*CP*G)-3'), MAGNESIUM ION, RNA (5'-R(*UP*CP*GP*AP*CP*A)-3'), ... | 著者 | Fang, Z, Qin, L, Huang, Z. | 登録日 | 2017-02-13 | 公開日 | 2017-03-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate Chemistryselect, 8, 2023
|
|
4RHD
| DNA Duplex with Novel ZP Base Pair | 分子名称: | DNA 9mer novel P nucleobase, DNA 9mer novel Z nucleobase, MAGNESIUM ION | 著者 | Zhang, W, Zhang, L, Benner, S, Huang, Z. | 登録日 | 2014-10-01 | 公開日 | 2015-07-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Evolution of functional six-nucleotide DNA. J.Am.Chem.Soc., 137, 2015
|
|
6X5D
| |
3BM0
| |
6NUD
| Small conformation of ssRNA-bound CRISPR_Csm complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms protein Csm2, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ... | 著者 | Zhang, K, Pintilie, G, Li, S, Zhu, Y, Chiu, W, Huang, Z. | 登録日 | 2019-01-31 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry. Cell Res., 29, 2019
|
|
6NUE
| Small conformation of apo CRISPR_Csm complex | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms protein Csm2, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ... | 著者 | Zhang, K, Pintilie, G, Li, S, Zhu, Y, Chiu, W, Huang, Z. | 登録日 | 2019-01-31 | 公開日 | 2019-03-13 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry. Cell Res., 29, 2019
|
|
3IJK
| 5-OMe modified DNA 8mer | 分子名称: | 5'-D(*GP*(UMS)P*GP*(T5O)P*AP*CP*AP*C)-3' | 著者 | Sheng, J, Zhang, W, Hassan, A.E.A, Gan, J, Huang, Z. | 登録日 | 2009-08-04 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate Chemistryselect, 8, 2023
|
|
6AEG
| Crystal structure of xCas9 in complex with sgRNA and target DNA (GAT PAM) | 分子名称: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*GP*AP*TP*TP*AP*TP*TP*G)-3'), DNA nuclease, ... | 著者 | Guo, M, Ren, K, Zhu, Y, Huang, Z. | 登録日 | 2018-08-04 | 公開日 | 2019-03-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Structural insights into a high fidelity variant of SpCas9. Cell Res., 29, 2019
|
|
6AEB
| Crystal structure of xCas9 in complex with sgRNA and target DNA (AAG PAM) | 分子名称: | DNA (25-MER), DNA (5'-D(*AP*AP*AP*AP*AP*GP*TP*AP*TP*TP*G)-3'), DNA Nuclease, ... | 著者 | Guo, M, Ren, K, Zhu, Y, Huang, Z. | 登録日 | 2018-08-04 | 公開日 | 2019-03-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.004 Å) | 主引用文献 | Structural insights into a high fidelity variant of SpCas9. Cell Res., 29, 2019
|
|
8IAZ
| Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex | 分子名称: | DNA (5'-D(P*AP*CP*AP*TP*GP*GP*AP*CP*CP*AP*TP*CP*AP*GP*CP*TP*CP*CP*TP*AP*AP*TP*GP*G)-3'), DNA (5'-D(P*CP*CP*AP*TP*TP*AP*GP*GP*AP*GP*CP*TP*GP*AP*TP*G)-3'), RNA (207-MER), ... | 著者 | Yin, M, Zhou, F, Zhu, Y, Huang, Z. | 登録日 | 2023-02-09 | 公開日 | 2024-04-17 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs. Cell Res., 34, 2024
|
|
3FA1
| |
4AQC
| Triazolopyridine-based Inhibitor of Janus Kinase 2 | 分子名称: | 8-(4-methylsulfonylphenyl)-N-(4-morpholin-4-ylphenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-amine, SULFATE ION, TYROSINE-PROTEIN KINASE JAK2 | 著者 | Dugan, B.J, Gingrich, D.E, Mesaros, E.F, Milkiewicz, K.L, Curry, M.A, Zulli, A.L, Dobrzanski, P, Serdikoff, C, Jan, M, Angeles, T.S, Albom, M.S, Mason, J.L, Aimone, L.D, Meyer, S.L, Huang, Z, Wells-Knecht, K.J, Ator, M.A, Ruggeri, B.A, Dorsey, B.D. | 登録日 | 2012-04-16 | 公開日 | 2012-04-25 | 最終更新日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5-A]Pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of Cep-33779. J.Med.Chem., 55, 2012
|
|
3HGA
| |
3HGD
| |
5ID6
| Structure of Cpf1/RNA Complex | 分子名称: | Cpf1, MAGNESIUM ION, RNA (5'-R(P*AP*AP*UP*UP*UP*CP*UP*AP*CP*UP*AP*AP*GP*UP*GP*UP*AP*GP*AP*UP*C)-3') | 著者 | Dong, D, Ren, K, Qiu, X, Wang, J, Huang, Z. | 登録日 | 2016-02-24 | 公開日 | 2016-04-27 | 最終更新日 | 2016-05-11 | 実験手法 | X-RAY DIFFRACTION (2.382 Å) | 主引用文献 | The crystal structure of Cpf1 in complex with CRISPR RNA Nature, 532, 2016
|
|
8J7S
| Structure of the SPARTA complex | 分子名称: | DNA (5'-D(P*TP*AP*AP*TP*AP*GP*AP*TP*TP*AP*GP*AP*GP*CP*CP*GP*TP*CP*AP*AP*TP*AP*GP*A)-3'), Piwi domain-containing protein, RNA (5'-R(P*UP*GP*AP*CP*GP*GP*CP*UP*CP*UP*AP*AP*UP*CP*UP*AP*UP*UP*A)-3'), ... | 著者 | Guo, M, Zhu, Y, Lin, Z, Huang, Z. | 登録日 | 2023-04-28 | 公開日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Cryo-EM structure of the ssDNA-activated SPARTA complex. Cell Res., 33, 2023
|
|
4DWI
| Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with self complementary DNA, Se-dGTP and Calcium | 分子名称: | 9-METHYLGUANINE, CALCIUM ION, DNA (5'-D(*AP*CP*TP*GP*GP*AP*TP*CP*CP*A)-3'), ... | 著者 | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | 登録日 | 2012-02-24 | 公開日 | 2013-03-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase To be Published
|
|
4YS5
| |
2O8T
| Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q) in complex with Inhibitors | 分子名称: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, SULFATE ION, ... | 著者 | Zhao, G, Yuan, C, Jiang, L, Huang, Z, Huang, M. | 登録日 | 2006-12-12 | 公開日 | 2007-12-25 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Crystal Structure and Binding Epitopes of Urokinase-type Plasminogen Activator (C122A/N145Q/S195A) in complex with Inhibitors To be Published
|
|
4DSK
| Crystal structure of fragment DNA polymerase I from Bacillus stearothermophilus with duplex DNA, PPi and Calcium | 分子名称: | CALCIUM ION, DNA (5'-D(*GP*GP*CP*TP*AP*CP*AP*GP*GP*AP*CP*TP*CP*G)-3'), DNA (5'-D(*TP*CP*AP*CP*GP*AP*GP*TP*CP*CP*TP*GP*TP*AP*GP*CP*C)-3'), ... | 著者 | Gan, J.H, Abdur, R, Liu, H.H, Sheng, J, Caton-Willians, J, Soares, A.S, Huang, Z. | 登録日 | 2012-02-19 | 公開日 | 2013-03-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Biochemical and structural insights into the fidelity of bacillus stearothermophilus DNA polymerase To be Published
|
|