3H54
 
 | | Crystal Structure of human alpha-N-acetylgalactosaminidase,complex with GalNAc | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Clark, N.E, Garman, S.C. | | 登録日 | 2009-04-21 | | 公開日 | 2009-10-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases
J.Mol.Biol., 393, 2009
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3LX9
 | | Interconversion of Human Lysosomal Enzyme Specificities | | 分子名称: | 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | | 著者 | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | | 登録日 | 2010-02-25 | | 公開日 | 2010-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases.
J.Biol.Chem., 285, 2010
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3HG4
 | | Human alpha-galactosidase catalytic mechanism 3. Covalent intermediate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Guce, A.I, Clark, N.E, Garman, S.C. | | 登録日 | 2009-05-13 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Catalytic mechanism of human alpha-galactosidase.
J.Biol.Chem., 285, 2010
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3HG5
 | | Human alpha-galactosidase catalytic mechanism 4. Product bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, Alpha-galactosidase A, ... | | 著者 | Guce, A.I, Clark, N.E, Garman, S.C. | | 登録日 | 2009-05-13 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Catalytic mechanism of human alpha-galactosidase.
J.Biol.Chem., 285, 2010
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3HG2
 | | Human alpha-galactosidase catalytic mechanism 1. Empty active site | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, Alpha-galactosidase A, ... | | 著者 | Guce, A.I, Clark, N.E, Garman, S.C. | | 登録日 | 2009-05-13 | | 公開日 | 2009-11-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Catalytic mechanism of human alpha-galactosidase.
J.Biol.Chem., 285, 2010
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3LXA
 | | Interconversion of Human Lysosomal Enzyme Specificities | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | | 著者 | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | | 登録日 | 2010-02-25 | | 公開日 | 2010-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.04 Å) | | 主引用文献 | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases.
J.Biol.Chem., 285, 2010
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3HG3
 | | Human alpha-galactosidase catalytic mechanism 2. Substrate bound | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | | 著者 | Guce, A.I, Clark, N.E, Garman, S.C. | | 登録日 | 2009-05-13 | | 公開日 | 2009-11-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Catalytic mechanism of human alpha-galactosidase.
J.Biol.Chem., 285, 2010
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3IGU
 | | Crystal structure of human alpha-N-acetylgalactosaminidase, covalent intermediate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Clark, N.E, Garman, S.C. | | 登録日 | 2009-07-28 | | 公開日 | 2009-10-20 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases
J.Mol.Biol., 393, 2009
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4DO5
 | | Pharmacological chaperones for human alpha-N-acetylgalactosaminidase | | 分子名称: | (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Clark, N.E, Garman, S.C. | | 登録日 | 2012-02-09 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | | 主引用文献 | Pharmacological chaperones for human alpha-N-acetylgalactosaminidase
Proc.Natl.Acad.Sci.USA, 109, 2012
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3LXC
 | | Interconversion of Human Lysosomal Enzyme Specificities | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, GLYCEROL, ... | | 著者 | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | | 登録日 | 2010-02-25 | | 公開日 | 2010-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases.
J.Biol.Chem., 285, 2010
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3LXB
 | | Interconversion of Human Lysosomal Enzyme Specificities | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-galactosidase A, ... | | 著者 | Tomasic, I.B, Metcalf, M.C, Guce, A.I, Clark, N.E, Garman, S.C. | | 登録日 | 2010-02-25 | | 公開日 | 2010-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases.
J.Biol.Chem., 285, 2010
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4DO6
 | | Pharmacological chaperones for human alpha-N-acetylgalactosaminidase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-N-acetylgalactosaminidase, ... | | 著者 | Clark, N.E, Garman, S.C. | | 登録日 | 2012-02-09 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Pharmacological chaperones for human alpha-N-acetylgalactosaminidase
Proc.Natl.Acad.Sci.USA, 109, 2012
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4DO4
 | | Pharmacological chaperones for human alpha-N-acetylgalactosaminidase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, ... | | 著者 | Clark, N.E, Garman, S.C. | | 登録日 | 2012-02-09 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Pharmacological chaperones for human alpha-N-acetylgalactosaminidase
Proc.Natl.Acad.Sci.USA, 109, 2012
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4Z2W
 | | Factor Inhibiting HIF in Complex with Fe, and Alpha-Ketoglutarate | | 分子名称: | 2-OXOGLUTARIC ACID, DI(HYDROXYETHYL)ETHER, FE (III) ION, ... | | 著者 | Taabazuing, C.Y, Garman, S.C, Knapp, M.J. | | 登録日 | 2015-03-30 | | 公開日 | 2016-01-13 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Substrate Promotes Productive Gas Binding in the alpha-Ketoglutarate-Dependent Oxygenase FIH.
Biochemistry, 55, 2016
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4Z1V
 | | Structure of Factor Inhibiting HIF (FIH) in complex with Fe, NO, and NOG | | 分子名称: | DI(HYDROXYETHYL)ETHER, FE (III) ION, Hypoxia-inducible factor 1-alpha inhibitor, ... | | 著者 | Taabazuing, C.Y, Garman, S.C, Knapp, M.J. | | 登録日 | 2015-03-27 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Substrate Promotes Productive Gas Binding in the alpha-Ketoglutarate-Dependent Oxygenase FIH.
Biochemistry, 55, 2016
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5I8R
 | | aSMase with zinc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingomyelin phosphodiesterase, ... | | 著者 | Zhou, Y.F, Wei, R.R. | | 登録日 | 2016-02-19 | | 公開日 | 2016-09-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.646 Å) | | 主引用文献 | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
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5I81
 | | aSMase with zinc | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... | | 著者 | Zhou, Y.F, Wei, R.R. | | 登録日 | 2016-02-18 | | 公開日 | 2016-09-07 | | 最終更新日 | 2021-03-24 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
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5I85
 | | aSMase with zinc and phosphocholine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOCHOLINE, ... | | 著者 | Zhou, Y.F, Wei, R.R. | | 登録日 | 2016-02-18 | | 公開日 | 2016-09-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
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5JWP
 | | Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide. | | 分子名称: | 2-OXOGLUTARIC ACID, GLYCEROL, Hypoxia-inducible factor 1-alpha, ... | | 著者 | Taabazuing, C.Y, Garman, S.C, Eron, S, Knapp, M.J. | | 登録日 | 2016-05-12 | | 公開日 | 2016-11-23 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The facial triad in the alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.
J.Inorg.Biochem., 166, 2016
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7N6M
 | | Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RQKPLLGLSR | | 分子名称: | Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION | | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | | 登録日 | 2021-06-08 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7N6K
 | | Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RALALLPLSR | | 分子名称: | Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION | | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | | 登録日 | 2021-06-08 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7N6J
 | | Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RKQSTIALALLPLLFTPRR | | 分子名称: | Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION | | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | | 登録日 | 2021-06-08 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7N6L
 | | Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide EANQQKPLLGLFADG | | 分子名称: | Alkaline phosphatase peptide, Chaperone protein DnaK, GLYCEROL, ... | | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | | 登録日 | 2021-06-08 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7JNE
 | | Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide RGSQLRIASR | | 分子名称: | Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION | | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | | 登録日 | 2020-08-04 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7JN9
 | | Crystal structure of the substrate-binding domain of E. coli DnaK in complex with the peptide QEHTGSQLRIAAYGP | | 分子名称: | Alkaline phosphatase peptide, Chaperone protein DnaK, SULFATE ION | | 著者 | Jansen, R.M, Ozden, C, Gierasch, L.M, Garman, S.C. | | 登録日 | 2020-08-04 | | 公開日 | 2020-08-26 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Selective promiscuity in the binding of E. coli Hsp70 to an unfolded protein.
Proc.Natl.Acad.Sci.USA, 118, 2021
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