3IGU

Crystal structure of human alpha-N-acetylgalactosaminidase, covalent intermediate

Summary for 3IGU

Entry DOI	10.2210/pdb3igu/pdb
Related	3H53 3H54 3H55
Descriptor	Alpha-N-acetylgalactosaminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
Functional Keywords	glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, schindler disease, kanzaki disease, disease mutation, disulfide bond, epilepsy, hydrolase, lysosome, phosphoprotein
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P17050
Total number of polymer chains	2
Total formula weight	96206.42
Authors	Clark, N.E.,Garman, S.C. (deposition date: 2009-07-28, release date: 2009-10-20, Last modification date: 2023-09-06)
Primary citation	Clark, N.E.,Garman, S.C. The 1.9 a structure of human alpha-N-acetylgalactosaminidase: The molecular basis of Schindler and Kanzaki diseases J.Mol.Biol., 393:435-447, 2009 Cited by PubMed: 19683538 DOI: 10.1016/j.jmb.2009.08.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.15 Å)

Structure validation