5JWP

Crystal structure of human FIH D201E variant in complex with Zn, alpha-ketoglutarate, and HIF1 alpha peptide.

Summary for 5JWP

• Entry DOI: 10.2210/pdb5jwp/pdb
• Related: 5JWK 5JWL
• Descriptor: Hypoxia-inducible factor 1-alpha inhibitor, Hypoxia-inducible factor 1-alpha, 2-OXOGLUTARIC ACID, ... (7 entities in total)
• Functional Keywords: hypoxia sensing, factor inhibiting hif, alpha-ketoglutarate dependent oxygenase, hypoxia inducible factor, hydroxylase, oxidoreductase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 43331.56

Authors

Taabazuing, C.Y.,Garman, S.C.,Eron, S.,Knapp, M.J. (deposition date: 2016-05-12, release date: 2016-11-23, Last modification date: 2023-09-27)

• Primary citation: Hangasky, J.A.,Taabazuing, C.Y.,Martin, C.B.,Eron, S.J.,Knapp, M.J.; The facial triad in the alpha-ketoglutarate dependent oxygenase FIH: A role for sterics in linking substrate binding to O2 activation.; J.Inorg.Biochem., 166:26-33, 2016; PubMed: 27815979; DOI: 10.1016/j.jinorgbio.2016.10.007

Experimental method

X-RAY DIFFRACTION (2.1 Å)