4Z2W

Factor Inhibiting HIF in Complex with Fe, and Alpha-Ketoglutarate

Summary for 4Z2W

Related4Z1V
DescriptorHypoxia-inducible factor 1-alpha inhibitor, 2-OXOGLUTARIC ACID, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
Functional Keywordshypoxia inducible factor, factor inhibiting hif, oxygenase, oxygen sensing, oxidoreductase
Biological sourceHomo sapiens (Human)
Cellular locationNucleus Q9NWT6
Total number of polymer chains1
Total molecular weight41398.93
Authors
Taabazuing, C.Y.,Garman, S.C.,Knapp, M.J. (deposition date: 2015-03-30, release date: 2016-01-13, Last modification date: 2016-01-27)
Primary citation
Taabazuing, C.Y.,Fermann, J.,Garman, S.,Knapp, M.J.
Substrate Promotes Productive Gas Binding in the alpha-Ketoglutarate-Dependent Oxygenase FIH.
Biochemistry, 55:277-286, 2016
PubMed: 26727884 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.5b01003
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.249600.7%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution