4Z2W
Factor Inhibiting HIF in Complex with Fe, and Alpha-Ketoglutarate
Summary for 4Z2W
Entry DOI | 10.2210/pdb4z2w/pdb |
Related | 4Z1V |
Descriptor | Hypoxia-inducible factor 1-alpha inhibitor, 2-OXOGLUTARIC ACID, DI(HYDROXYETHYL)ETHER, ... (6 entities in total) |
Functional Keywords | hypoxia inducible factor, factor inhibiting hif, oxygenase, oxygen sensing, oxidoreductase |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus: Q9NWT6 |
Total number of polymer chains | 1 |
Total formula weight | 41398.93 |
Authors | Taabazuing, C.Y.,Garman, S.C.,Knapp, M.J. (deposition date: 2015-03-30, release date: 2016-01-13, Last modification date: 2024-03-06) |
Primary citation | Taabazuing, C.Y.,Fermann, J.,Garman, S.,Knapp, M.J. Substrate Promotes Productive Gas Binding in the alpha-Ketoglutarate-Dependent Oxygenase FIH. Biochemistry, 55:277-286, 2016 Cited by PubMed: 26727884DOI: 10.1021/acs.biochem.5b01003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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