3LXC

Interconversion of Human Lysosomal Enzyme Specificities

Summary for 3LXC

Entry DOI	10.2210/pdb3lxc/pdb
Related	1R46 3HG2 3LX9 3LXA 3LXB
Descriptor	Alpha-galactosidase A, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
Functional Keywords	glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, enzyme interconversion, disease mutation, disulfide bond, hydrolase, lysosome
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	95883.93
Authors	Tomasic, I.B.,Metcalf, M.C.,Guce, A.I.,Clark, N.E.,Garman, S.C. (deposition date: 2010-02-25, release date: 2010-05-05, Last modification date: 2023-09-06)
Primary citation	Tomasic, I.B.,Metcalf, M.C.,Guce, A.I.,Clark, N.E.,Garman, S.C. Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases. J.Biol.Chem., 285:21560-21566, 2010 Cited by PubMed: 20444686 DOI: 10.1074/jbc.M110.118588 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.35 Å)

Structure validation