3LXC
Interconversion of Human Lysosomal Enzyme Specificities
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Alpha-galactosidase A | polymer | 404 | 46139.3 | 2 | UniProt (P06280) Pfam (PF16499) Pfam (PF17450) In PDB | Homo sapiens (human) | Alpha-D-galactoside galactohydrolase, Alpha-D-galactosidase A, Melibiase |
2 | C, F | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 2 | In PDB GlyTouCan (G81315DD) | |||
3 | D | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 894.8 | 1 | In PDB GlyTouCan (G17689EW) | |||
4 | E | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
5 | A, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
6 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
7 | water | water | 18.0 | 552 | Chemie (HOH) |
Sequence modifications
A, B: 32 - 429 (UniProt: P06280)
PDB | External Database | Details |
---|---|---|
Ser 203 | Glu 203 | engineered mutation |
Ala 206 | Leu 206 | engineered mutation |
His 430 | - | expression tag |
His 431 | - | expression tag |
His 432 | - | expression tag |
His 433 | - | expression tag |
His 434 | - | expression tag |
His 435 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 92278.6 | |
Branched | Number of molecules | 4 |
Total formula weight | 2978.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 626.6 | |
All* | Total formula weight | 95883.9 |