5V9U
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![BU of 5v9u by Molmil](/molmil-images/mine/5v9u) | Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C | 分子名称: | (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | 著者 | Janes, M.R, Zhang, J, Li, L.-S, Hansen, R, Peters, U, Guo, X, Chen, Y, Babbar, A, Firdaus, S.J, Feng, J, Chen, J.H, Li, S, Brehmer, D, Darjania, L, Li, S, Long, Y.O, Thach, C, Liu, Y, Zarieh, A, Ely, T, Kucharski, J.M, Kessler, L.V, Wu, T, Wang, Y, Yao, Y, Deng, X, Zarrinkar, P, Dashyant, D, Lorenzi, M.V, Hu-Lowe, D, Patricelli, M.P, Ren, P, Liu, Y. | 登録日 | 2017-03-23 | 公開日 | 2018-02-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell, 172, 2018
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3Q7J
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![BU of 3q7j by Molmil](/molmil-images/mine/3q7j) | Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development | 分子名称: | L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, Tricorn protease-interacting factor F3, ZINC ION | 著者 | Su, J, Wang, Q, Feng, J, Zhang, C, Zhu, D, We, T, Xu, W, Gu, L. | 登録日 | 2011-01-05 | 公開日 | 2011-07-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development Bioorg.Med.Chem., 19, 2011
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4R3Q
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![BU of 4r3q by Molmil](/molmil-images/mine/4r3q) | Crystal structure of SYCE3 | 分子名称: | Synaptonemal complex central element protein 3 | 著者 | Lu, J, Feng, J, Zhou, W, Yang, X, Shen, Y. | 登録日 | 2014-08-17 | 公開日 | 2014-11-26 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Structural insight into the central element assembly of the synaptonemal complex Sci Rep, 4, 2014
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6B0V
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![BU of 6b0v by Molmil](/molmil-images/mine/6b0v) | Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C | 分子名称: | 1-[3-(4-{[(4,5-dichloro-2-hydroxyphenyl)amino]acetyl}piperazin-1-yl)azetidin-1-yl]propan-1-one, CALCIUM ION, GTPase KRas, ... | 著者 | Hansen, R, Peters, U, Babbar, A, Chen, Y, Feng, J, Janes, M.R, Li, L.-S, Ren, P, Liu, Y, Zarrinkar, P.P. | 登録日 | 2017-09-15 | 公開日 | 2018-05-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors. Nat. Struct. Mol. Biol., 25, 2018
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5F2E
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![BU of 5f2e by Molmil](/molmil-images/mine/5f2e) | Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C | 分子名称: | 1-[3-[4-[2-[[4-chloranyl-5-(1-methylcyclopropyl)-2-oxidanyl-phenyl]amino]ethanoyl]piperazin-1-yl]azetidin-1-yl]prop-2-en-1-one, GLYCEROL, GLYCINE, ... | 著者 | Patricelli, M.P, Janes, M.R, Li, L.-S, Hansen, R, Peters, U, Kessler, L.V, Chen, Y, Kucharski, J.M, Feng, J, Ely, T, Chen, J.H, Firdaus, S.J, Babbar, A, Ren, P, Liu, Y. | 登録日 | 2015-12-01 | 公開日 | 2016-01-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discov, 6, 2016
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6B0Y
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![BU of 6b0y by Molmil](/molmil-images/mine/6b0y) | Crystal Structure of small molecule ARS-917 covalently bound to K-Ras G12C | 分子名称: | 1-{4-[6-chloro-7-(2-fluorophenyl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | 著者 | Hansen, R, Peters, U, Babbar, A, Chen, Y, Feng, J, Janes, M.R, Li, L.-S, Ren, P, Liu, Y, Zarrinkar, P.P. | 登録日 | 2017-09-15 | 公開日 | 2018-05-16 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | 主引用文献 | The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors. Nat. Struct. Mol. Biol., 25, 2018
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4I23
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![BU of 4i23 by Molmil](/molmil-images/mine/4i23) | Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked) | 分子名称: | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide, Epidermal growth factor receptor | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | 登録日 | 2012-11-21 | 公開日 | 2013-01-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
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4I21
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![BU of 4i21 by Molmil](/molmil-images/mine/4i21) | Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide | 分子名称: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | 登録日 | 2012-11-21 | 公開日 | 2013-01-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
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4I20
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![BU of 4i20 by Molmil](/molmil-images/mine/4i20) | Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain | 分子名称: | Epidermal growth factor receptor | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | 登録日 | 2012-11-21 | 公開日 | 2013-01-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
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4I24
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![BU of 4i24 by Molmil](/molmil-images/mine/4i24) | Structure of T790M EGFR kinase domain co-crystallized with dacomitinib | 分子名称: | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide, Epidermal growth factor receptor | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | 登録日 | 2012-11-21 | 公開日 | 2013-01-16 | 最終更新日 | 2013-02-27 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
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4I1Z
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![BU of 4i1z by Molmil](/molmil-images/mine/4i1z) | Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M | 分子名称: | Epidermal growth factor receptor | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | 登録日 | 2012-11-21 | 公開日 | 2013-01-16 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
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4I22
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![BU of 4i22 by Molmil](/molmil-images/mine/4i22) | Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib | 分子名称: | Epidermal growth factor receptor, Gefitinib, SULFATE ION | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | 登録日 | 2012-11-21 | 公開日 | 2013-01-16 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition. Structure, 21, 2013
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8TZU
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![BU of 8tzu by Molmil](/molmil-images/mine/8tzu) | OC43 S1b domain in complex with WNb 293 and WNb 317 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Pymm, P, Feng, J, Tham, W.H. | 登録日 | 2023-08-27 | 公開日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | OC43 S1b domain in complex with WNb 293 and WNb 317 To Be Published
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8W7M
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![BU of 8w7m by Molmil](/molmil-images/mine/8w7m) | Yeast replisome in state V | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (71-mer), ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | 登録日 | 2023-08-30 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.12 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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8W7S
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![BU of 8w7s by Molmil](/molmil-images/mine/8w7s) | Yeast replisome in state IV | 分子名称: | Cell division control protein 45, DNA (71-mer), DNA polymerase alpha-binding protein, ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D. | 登録日 | 2023-08-31 | 公開日 | 2023-12-20 | 実験手法 | ELECTRON MICROSCOPY (7.39 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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8KG8
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![BU of 8kg8 by Molmil](/molmil-images/mine/8kg8) | Yeast replisome in state II | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | 登録日 | 2023-08-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.23 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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8KG9
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![BU of 8kg9 by Molmil](/molmil-images/mine/8kg9) | Yeast replisome in state III | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | 登録日 | 2023-08-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.52 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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8KG6
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![BU of 8kg6 by Molmil](/molmil-images/mine/8kg6) | Yeast replisome in state I | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | 登録日 | 2023-08-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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1XPI
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1SI7
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![BU of 1si7 by Molmil](/molmil-images/mine/1si7) | Structure of E. coli tRNA psi 13 pseudouridine synthase TruD | 分子名称: | tRNA pseudouridine synthase D | 著者 | Kaya, Y, Del Campo, M, Ofengand, J, Malhotra, A. | 登録日 | 2004-02-27 | 公開日 | 2004-03-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold J.Biol.Chem., 279, 2004
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1QYU
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![BU of 1qyu by Molmil](/molmil-images/mine/1qyu) | |
3CCB
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![BU of 3ccb by Molmil](/molmil-images/mine/3ccb) | |
6XE1
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![BU of 6xe1 by Molmil](/molmil-images/mine/6xe1) | |
6KTO
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8FY7
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![BU of 8fy7 by Molmil](/molmil-images/mine/8fy7) | SARS-CoV-2 main protease in complex with covalent inhibitor | 分子名称: | 3C-like proteinase nsp5, 4-methoxy-N-[(2S)-4-methyl-1-oxo-1-({(2S)-1-[(3S)-2-oxopyrrolidin-3-yl]but-3-en-2-yl}amino)pentan-2-yl]-1H-indole-2-carboxamide | 著者 | Fried, W, Chen, X.S. | 登録日 | 2023-01-25 | 公開日 | 2023-08-30 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | 主引用文献 | Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease. J.Med.Chem., 66, 2023
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