5V9U
 
 | | Crystal Structure of small molecule ARS-1620 covalently bound to K-Ras G12C | | 分子名称: | (S)-1-{4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl] piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | | 著者 | Janes, M.R, Zhang, J, Li, L.-S, Hansen, R, Peters, U, Guo, X, Chen, Y, Babbar, A, Firdaus, S.J, Feng, J, Chen, J.H, Li, S, Brehmer, D, Darjania, L, Li, S, Long, Y.O, Thach, C, Liu, Y, Zarieh, A, Ely, T, Kucharski, J.M, Kessler, L.V, Wu, T, Wang, Y, Yao, Y, Deng, X, Zarrinkar, P, Dashyant, D, Lorenzi, M.V, Hu-Lowe, D, Patricelli, M.P, Ren, P, Liu, Y. | | 登録日 | 2017-03-23 | | 公開日 | 2018-02-07 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor.
Cell, 172, 2018
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3Q7J
 | | Engineered Thermoplasma Acidophilum F3 factor mimics human aminopeptidase N (APN) as a target for anticancer drug development | | 分子名称: | L-phenylalanyl-N6-[(benzyloxy)carbonyl]-N1-hydroxy-L-lysinamide, Tricorn protease-interacting factor F3, ZINC ION | | 著者 | Su, J, Wang, Q, Feng, J, Zhang, C, Zhu, D, We, T, Xu, W, Gu, L. | | 登録日 | 2011-01-05 | | 公開日 | 2011-07-27 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | | 主引用文献 | Engineered Thermoplasma acidophilum factor F3 mimics human aminopeptidase N (APN) as a target for anticancer drug development
Bioorg.Med.Chem., 19, 2011
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4R3Q
 | | Crystal structure of SYCE3 | | 分子名称: | Synaptonemal complex central element protein 3 | | 著者 | Lu, J, Feng, J, Zhou, W, Yang, X, Shen, Y. | | 登録日 | 2014-08-17 | | 公開日 | 2014-11-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Structural insight into the central element assembly of the synaptonemal complex
Sci Rep, 4, 2014
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6B0V
 | | Crystal Structure of small molecule ARS-107 covalently bound to K-Ras G12C | | 分子名称: | 1-[3-(4-{[(4,5-dichloro-2-hydroxyphenyl)amino]acetyl}piperazin-1-yl)azetidin-1-yl]propan-1-one, CALCIUM ION, GTPase KRas, ... | | 著者 | Hansen, R, Peters, U, Babbar, A, Chen, Y, Feng, J, Janes, M.R, Li, L.-S, Ren, P, Liu, Y, Zarrinkar, P.P. | | 登録日 | 2017-09-15 | | 公開日 | 2018-05-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | | 主引用文献 | The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors.
Nat. Struct. Mol. Biol., 25, 2018
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5F2E
 | | Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C | | 分子名称: | 1-[3-[4-[2-[[4-chloranyl-5-(1-methylcyclopropyl)-2-oxidanyl-phenyl]amino]ethanoyl]piperazin-1-yl]azetidin-1-yl]prop-2-en-1-one, GLYCEROL, GLYCINE, ... | | 著者 | Patricelli, M.P, Janes, M.R, Li, L.-S, Hansen, R, Peters, U, Kessler, L.V, Chen, Y, Kucharski, J.M, Feng, J, Ely, T, Chen, J.H, Firdaus, S.J, Babbar, A, Ren, P, Liu, Y. | | 登録日 | 2015-12-01 | | 公開日 | 2016-01-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State.
Cancer Discov, 6, 2016
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6B0Y
 | | Crystal Structure of small molecule ARS-917 covalently bound to K-Ras G12C | | 分子名称: | 1-{4-[6-chloro-7-(2-fluorophenyl)quinazolin-4-yl]piperazin-1-yl}propan-1-one, CALCIUM ION, GLYCEROL, ... | | 著者 | Hansen, R, Peters, U, Babbar, A, Chen, Y, Feng, J, Janes, M.R, Li, L.-S, Ren, P, Liu, Y, Zarrinkar, P.P. | | 登録日 | 2017-09-15 | | 公開日 | 2018-05-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | The reactivity-driven biochemical mechanism of covalent KRASG12Cinhibitors.
Nat. Struct. Mol. Biol., 25, 2018
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4I23
 | | Crystal structure of the wild-type EGFR kinase domain in complex with dacomitinib (soaked) | | 分子名称: | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide, Epidermal growth factor receptor | | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | | 登録日 | 2012-11-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
Structure, 21, 2013
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4I21
 | | Crystal structure of L858R + T790M EGFR kinase domain in complex with MIG6 peptide | | 分子名称: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor | | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | | 登録日 | 2012-11-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
Structure, 21, 2013
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4I20
 | | Crystal structure of monomeric (V948R) primary oncogenic mutant L858R EGFR kinase domain | | 分子名称: | Epidermal growth factor receptor | | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | | 登録日 | 2012-11-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.34 Å) | | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
Structure, 21, 2013
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4I24
 | | Structure of T790M EGFR kinase domain co-crystallized with dacomitinib | | 分子名称: | (2E)-N-{4-[(3-chloro-4-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}-4-(piperidin-1-yl)but-2-enamide, Epidermal growth factor receptor | | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | | 登録日 | 2012-11-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2013-02-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
Structure, 21, 2013
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4I1Z
 | | Crystal structure of the monomeric (V948R) form of the gefitinib/erlotinib resistant EGFR kinase domain L858R+T790M | | 分子名称: | Epidermal growth factor receptor | | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | | 登録日 | 2012-11-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
Structure, 21, 2013
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4I22
 | | Structure of the monomeric (V948R)gefitinib/erlotinib resistant double mutant (L858R+T790M) EGFR kinase domain co-crystallized with gefitinib | | 分子名称: | Epidermal growth factor receptor, Gefitinib, SULFATE ION | | 著者 | Gajiwala, K.S, Feng, J, Ferre, R, Ryan, K, Brodsky, O, Stewart, A. | | 登録日 | 2012-11-21 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | | 主引用文献 | Insights into the Aberrant Activity of Mutant EGFR Kinase Domain and Drug Recognition.
Structure, 21, 2013
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8TZU
 | | OC43 S1b domain in complex with WNb 293 and WNb 317 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | | 著者 | Pymm, P, Feng, J, Tham, W.H. | | 登録日 | 2023-08-27 | | 公開日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | OC43 S1b domain in complex with WNb 293 and WNb 317
To Be Published
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8W7M
 | | Yeast replisome in state V | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (71-mer), ... | | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | 登録日 | 2023-08-30 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (4.12 Å) | | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8W7S
 | | Yeast replisome in state IV | | 分子名称: | Cell division control protein 45, DNA (71-mer), DNA polymerase alpha-binding protein, ... | | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D. | | 登録日 | 2023-08-31 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (7.39 Å) | | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8KG8
 | | Yeast replisome in state II | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | 登録日 | 2023-08-17 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (4.23 Å) | | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8KG9
 | | Yeast replisome in state III | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | 登録日 | 2023-08-17 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (4.52 Å) | | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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8KG6
 | | Yeast replisome in state I | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ... | | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | | 登録日 | 2023-08-17 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork.
Nat Commun, 14, 2023
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1XPI
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1SI7
 | | Structure of E. coli tRNA psi 13 pseudouridine synthase TruD | | 分子名称: | tRNA pseudouridine synthase D | | 著者 | Kaya, Y, Del Campo, M, Ofengand, J, Malhotra, A. | | 登録日 | 2004-02-27 | | 公開日 | 2004-03-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of TruD, a novel pseudouridine synthase with a new protein fold
J.Biol.Chem., 279, 2004
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1QYU
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3CCB
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6XE1
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6KTO
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8FY7
 | | SARS-CoV-2 main protease in complex with covalent inhibitor | | 分子名称: | 3C-like proteinase nsp5, 4-methoxy-N-[(2S)-4-methyl-1-oxo-1-({(2S)-1-[(3S)-2-oxopyrrolidin-3-yl]but-3-en-2-yl}amino)pentan-2-yl]-1H-indole-2-carboxamide | | 著者 | Fried, W, Chen, X.S. | | 登録日 | 2023-01-25 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Alkyne as a Latent Warhead to Covalently Target SARS-CoV-2 Main Protease.
J.Med.Chem., 66, 2023
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